Endothelial and non-endothelial actions of estrogen receptor subtypes in male and female mouse aorta [0.03%]
雌激素受体亚型在雄性和雌性小鼠胸主动脉内皮和非内皮作用的性别二态性
Basant Elsaid,Irakli Kopaliani,Birgit Zatschler et al.
Basant Elsaid et al.
Estrogen's role in cardiovascular health remains inconsistent. This study investigates the non-genomic vasorelaxant effects of 17β-estradiol, focusing on sex-specific differences in estrogen receptor (ER) subtypes (ERα, ERβ, GPER), endot...
Emerging role of the adaptive immunity in aortic aneurysm and dissection [0.03%]
适应性免疫在主动脉瘤和夹层中的作用初探
Yan-Ni Hu,Mi Wang,Zheng Zhang
Yan-Ni Hu
Aortic aneurysm and dissection (AAD) is a critical aortic disease with high mortality. AAD is characterized by aortic inflammation, which manifests as the infiltration of immune cells and the accumulation of inflammatory mediators. Studies ...
Elastase-2 deletion prevents vascular remodeling and abdominal aortic aneurysm development in a mice model induced by angiotensin II [0.03%]
基质金属蛋白酶弹性蛋白酶-2基因缺失可抑制AngⅡ诱导的胸腹主动脉瘤小鼠模型中血管壁重构及动脉瘤形成
Fabiola Mestriner,Vinicius Flora Dugaich,Pedro Brüch Dantas et al.
Fabiola Mestriner et al.
Abdominal aortic aneurysm (AAA) involves the remodeling of the aortic wall extracellular matrix (ECM), compromising biomechanical support and increasing the risk of aortic dissection and rupture. Activation of the renin-angiotensin system (...
Growth differentiation factor 15 protects against diabetic endothelial dysfunction by AMP-activated protein kinase mediation [0.03%]
生长分化因子15通过AMP活化蛋白激酶介导对抗糖尿病内皮功能障碍作用
Wen Zhao,Yang Liu,Zhengshuo Cui et al.
Wen Zhao et al.
Aims: Endothelial dysfunction is a hallmark of diabetes-associated cardiovascular complications, yet its molecular mechanisms remain incompletely elucidated. Growth differentiation factor 15 (GDF15) has emerged as an impo...
Pre-eclampsia with inflammatory and pro-resolving mediator fluctuations - contributions from hemolytic protozoan parasites [0.03%]
溶血性原生动物寄生虫对炎症和促解决介质波动的子痫前期的影响
Kevin Roe
Kevin Roe
Pre-eclampsia (PE) and eclampsia are inflammatory hypertension diseases which have caused millions of global fatalities among pregnant women, and their pathogenesis has been a centuries-long mystery. Substantial experimental evidence, inclu...
Hypothalamic regulation of obesity: Revealing the therapeutic potential of a novel anti-obesity peptide [0.03%]
下丘脑肥胖调控：揭示一种新型抗肥胖多肽的治疗潜力
Yi Ning Choo,Ram Narayanan,Vetriselvan Subramaniyan
Yi Ning Choo
Obesity is a chronic, complex condition defined by excessive fat buildup due to an imbalance between caloric consumption and energy expenditure. The significant global rise in prevalence of obesity is associated with numerous comorbidities,...
The endothelium at the crossroads of multi-organ pathology: Insights from organ-on-chip models [0.03%]
器官芯片模型中的血管内皮细胞在多器官病理过程中的作用机制探究
Swachhatoa Ghosh,Praphulla C Shukla,Soumen Das
Swachhatoa Ghosh
Endothelial barrier function is indispensable in maintaining vascular-tissue-organ homeostasis. Altered release of vasoactive substances brings along with fluctuating shear stress patterns result in an impaired barrier function leading to t...
Efficacy and safety of lorundrostat in patients with uncontrolled or resistant hypertension: A systematic review and meta-analysis with trial sequential analysis [0.03%]
洛伦多斯他用于治疗难治性或未控制高血压的疗效和安全性：系统评价和 meta 分析及试验序贯分析
Laila Shalabi,Abdelrahman M Tawfik,Bashar M Al Zoubi et al.
Laila Shalabi et al.
Background: Uncontrolled hypertension (HTN) remains a challenge despite multiple anti-hypertensive medications. This study systematically evaluates the efficacy and safety of Lorundrostat, a novel aldosterone synthase inh...
Transcellular permeability of arterial endothelium to plasma LDL, an underexplored target in treating atherosclerosis: Novel insights and potential treatment strategies [0.03%]
动脉内皮细胞向低密度脂蛋白血浆的跨细胞转运——治疗动脉粥样硬化的一个尚未被充分开发的目标：新见解和潜在治疗方法
Israel O Bolanle,Gaetan de Liedekerke Beaufort
Israel O Bolanle
Ischaemic heart disease, of which atherosclerosis is the primary substrate, continues to be a leading cause of death globally. Atherosclerosis is characterised by the accumulation of cholesterol, mainly from circulating low-density lipoprot...
Apelin in glioblastoma: A dual target for tumor and vascular intervention [0.03%]
胶质母细胞瘤中的Apelin：肿瘤和血管双重干预的双靶点
Gabriela E Wachholz,Karlijn van Loon,Arjan W Griffioen
Gabriela E Wachholz
Glioblastoma (GBM) is the most prevalent and lethal primary brain tumor in adults, marked by rapid progression, profound intratumoral heterogeneity and poor prognosis despite multimodal therapy. Current standard-of-care treatments, includin...