Reprint of "Intra-aortic balloon counterpulsation--basic principles and clinical evidence" [0.03%]
主动脉内球囊反搏的基本原理和临床证据(附刊)
Suzanne de Waha,Steffen Desch,Ingo Eitel et al.
Suzanne de Waha et al.
Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decrea...
Chun-Yi Ng,Xin-Fang Leong,Norliana Masbah et al.
Chun-Yi Ng et al.
Cardiovascular disease (CVD) is one of the leading major causes of morbidity and mortality worldwide. It may result from the interactions between multiple genetic and environmental factors including sedentary lifestyle and dietary habits. T...
XiaoOu Mao,Lin Xie,Rose B Greenberg et al.
XiaoOu Mao et al.
Endothelial cell (EC) function and susceptibility to vascular disease are regulated by flow; this relationship has been modeled in systemic, but not cerebrovascular, EC culture. We studied the effects of unidirectional flow of medium, produ...
Effect of diet-induced obesity on BK(Ca) function in contraction and dilation of rat isolated middle cerebral artery [0.03%]
饮食诱导性肥胖对肥胖大鼠大脑中动脉收缩和舒张时BK(Ca)功能的影响
Lauren Howitt,Margaret J Morris,Shaun L Sandow et al.
Lauren Howitt et al.
This study examined the effect of diet-induced obesity on the functional role of large-conductance Ca²⁺-activated K⁺ channels (BK(Ca)) in rat middle cerebral arteries. Male Sprague-Dawley rats were fed a control (chow) or high-fat diet f...
Induction of heme oxygenase-1 ameliorates vascular dysfunction in streptozotocin-induced type 2 diabetic rats [0.03%]
诱导血红素氧合酶-1改善链尿佐菌素诱导的2型糖尿病大鼠的血管功能失调
Yang Wang,Lei Ying,Ying-ying Chen et al.
Yang Wang et al.
Aims: To explore the effects of heme oxygenase-1 (HO-1) on vascular dysfunction in high fat diet streptozotocin-induced type 2 diabetic (T2D) rats. Method...
Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway [0.03%]
沃格苷通过抑制PI3K/Akt/NF-κB信号转导途径抑制H2O2诱导的血管生成作用
Mi Zhou,Xiuming Song,Yujie Huang et al.
Mi Zhou et al.
Wogonin, a natural monoflavonoid extracted from Scutellariae radix, has been reported for its ability of inhibiting tumor angiogenesis. In this study, we assessed the effect of wogonin on angiogenesis induced by low level of H2O2 (10 μM) i...
Antiplatelet, anticoagulant, and profibrinolytic activities of withaferin A [0.03%]
Withaferin A的抗血小板、抗凝和促纤维蛋白溶解作用
Sae-Kwang Ku,Jong-Sup Bae
Sae-Kwang Ku
Withaferin A (WFA), an active compound from Withania somnifera, is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. However, antiplatelet, anticoagulant, and profibrinolytic properties of WFA hav...
Effect of systemic high dose vitamin C therapy on forearm blood flow reactivity during endotoxemia in healthy human subjects [0.03%]
大剂量维生素C治疗对内毒素血症健康受试者前臂血流量的影响
S Aschauer,G Gouya,U Klickovic et al.
S Aschauer et al.
Objective: Acute inflammation induced by administration of Escherichia coli lipopolysaccharide endotoxin (LPS) reduces plasma concentrations of vitamin C and impairs vascular endothelium-derived nitric oxide (NO) bioactiv...
Randomized Controlled Trial
Vascular pharmacology. 2014 Apr;61(1):25-9. DOI:10.1016/j.vph.2014.01.007 2014
Asenapine increases nitric oxide release and protects porcine coronary artery endothelial cells against peroxidation [0.03%]
阿塞那平增加一氧化氮释放并保护猪冠状动脉内皮细胞免受脂质过氧化侵害
Elena Grossini,Carla Gramaglia,Serena Farruggio et al.
Elena Grossini et al.
Changes in endothelial function and peroxidation could play a significant role in the pathophysiology of cardiovascular disease in psychiatric patients. In particular, endothelial nitric oxide (NO) could either exert a beneficial or detrime...
Endothelial nitric oxide synthase activation through obacunone-dependent arginase inhibition restored impaired endothelial function in ApoE-null mice [0.03%]
以Obacunone依赖性鸟氨酸脱羧酶抑制方式活化血管内皮型一氧化氮合酶可改善ApoE基因敲除小鼠的内皮功能障碍
Jeongyeon Yoon,Minjin Park,Jeong hyung Lee et al.
Jeongyeon Yoon et al.
Endothelial arginase constrains the activity of endothelial nitric oxide synthase (eNOS) by substrate depletion and reduces nitric oxide bioavailability. During the screening course of arginase inhibitor, we found obacunone as an arginase i...