New insights into the pharmacological inhibition of SRF activity: Key inhibitory targets and mechanisms [0.03%]
SRF活性药理学抑制的新见解：关键抑制靶点和机制
Daniel Wong,Hongyu Qiu
Daniel Wong
Serum Response Factor (SRF) is a critical regulatory transcription factor widely expressed across cell types and is essential for animal survival. Excessive SRF activity has been linked to various pathological conditions and diseases, inclu...
Patterns of medication use and potential drug-drug interactions in post-PCI patients: A study from Iran [0.03%]
伊朗经皮冠状动脉介入治疗术后患者的用药模式及潜在的药物相互作用研究
Reza Golchin Vafa,Hossein Molavi Vardanjani,Javad Kojuri
Reza Golchin Vafa
Background: Post-percutaneous coronary intervention (PCI) patients often require complex medication regimens to prevent adverse cardiovascular events. However, these regimens can lead to potential drug-drug interactions (...
Rosalinda Madonna,Filippo Biondi
Rosalinda Madonna
Sotatercept (brand name WINREVAIR, developed by Merck) is an activin receptor type IIA-Fc (ActRIIA-Fc), working by sequestering free activins. Sotatercept restores the balance between the activin proliferative pathway and the bone morphogen...
LncRNA MYOSLID contributes to PH via targeting BMPR2 signaling in pulmonary artery smooth muscle cell [0.03%]
长链非编码RNA MYOSLID通过靶向BMPR2信号通路参与肺动脉平滑肌细胞中的肺动脉高压发病机制
Yuan Chen,Yuan Li,Bin Leng et al.
Yuan Chen et al.
Background/objective: The pathogenesis and vascular remodeling during pulmonary hypertension (PH) have been associated with dysregulation of bone morphogenetic protein receptor type 2 (BMPR2) and transforming growth facto...
Prolonged L-NAME exposure changes the vasodilator factor from NO to H2O2 in human arterioles in response to A23187 [0.03%]
L-NAME长时间暴露下，人血管内皮细胞动脉管腔中NO介导的血管舒张向H₂O₂介导转化
Natalya S Zinkevich,Kostiantyn Drachuk,David X Zhang
Natalya S Zinkevich
The Ca2+ ionophore A23187 induces endothelium-dependent and non-receptor-mediated vasodilation in human adipose arterioles (HAAs). The purpose of this study was to determine the mechanism of A23187-induced dilation in HAAs from patients wit...
Functional characterization of human IL-8 in vascular stenosis using a novel humanized transgenic mouse model [0.03%]
人IL-8在血管狭窄中的功能表征：使用新型人源化转基因小鼠模型研究
Wei Zhang,Lihua Pan,Xiaoliang Wu et al.
Wei Zhang et al.
IL-8 (aka interleukin 8, CXCL8) is a prototypic cytokine that is highly expressed in the diseased vessel wall and its plasma concentration is strongly associated with cardiovascular events. However, whether IL-8 plays a causative role in ca...
Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue [0.03%]
腺苷酸活化蛋白激酶-α1缺乏降低胸主动脉外周脂肪组织一氧化氮合成
Abdmajid Hwej,Ali Al-Ferjani,Yazeed Alshuweishi et al.
Abdmajid Hwej et al.
Objective: Perivascular adipose tissue (PVAT) releases anti-contractile bioactive molecules including NO. PVAT anti-contractile activity is attenuated in mice lacking AMPKα1 (AMP-activated protein kinase-α1). As AMPK re...
Different gene expression patterns between mouse and human brain pericytes revealed by single-cell/nucleus RNA sequencing [0.03%]
单细胞/核RNA测序揭示小胶质细胞和人脑周细胞的不同基因表达模式
Yuyang Miao,Weihan Li,Marie Jeansson et al.
Yuyang Miao et al.
Aims: Pericytes in the brain play important roles for microvascular physiology and pathology and are affected in neurological disorders and neurodegenerative diseases. Mouse models are often utilized for pathophysiology s...
Comparative Study
Vascular pharmacology. 2024 Dec:157:107434. DOI:10.1016/j.vph.2024.107434 2024
Examining the controversies in venous thromboembolism prophylaxis for vascular surgery patients: A critical review [0.03%]
血管手术患者静脉血栓预防争议的批判性分析：系统评价和荟萃分析
Tao Fang,Ran Zhang,Yanmei Li
Tao Fang
Background: Venous thromboembolism (VTE) is a significant concern in vascular surgery due to its potentially severe consequences. Effective prophylactic measures are essential to minimize the risks associated with VTE. Ho...
Bioactive lipids improve serum HDL and PON1 activities in coronary artery disease patients: Ex-vivo study [0.03%]
生物活性脂质可改善冠心病患者的血清HDL和PON1活性：体外研究
Ali Khattib,Manar Shmet,Achinoam Levi et al.
Ali Khattib et al.
Background: Atherosclerotic cardiovascular disease (CVD) remains a leading cause of vascular disease worldwide. Atherosclerosis is characterized by the accumulation of lipids and oxidized lipids on the blood vessel walls....