Cellular uptake, induction of reactive oxygen species, and genotoxicity of differently sized cobalt oxide nanoparticles in human peripheral blood mononuclear cells in vitro [0.03%]
体外钴氧化物纳米颗粒的细胞摄取、活性氧生成及遗传毒性研究——基于人类外周血单个核细胞
Milda Babonaitė,Veronika Dedonytė,Emilija Striogaitė et al.
Milda Babonaitė et al.
Cobalt (II, III) oxide nanoparticles (Co3O4-NPs) have potential applications in different technological and medical fields, including drug delivery and as novel anticancer treatments. However, widespread application could lead to a high-lev...
Increased genotoxic damage in Sicilian donkeys reared in different conditions of air quality [0.03%]
不同空气质量条件下西西里岛驴的遗传毒性损害增加
Emanuele D&#x;Anza,Ilaria Cascone,Flavio Luongo et al.
Emanuele D&#x;Anza et al.
This study investigates chromosomal damage in donkeys to assess the impact of long-term exposure to different concentrations of environmental genotoxic agents, which pose health risks to animals and humans by promoting DNA breaks. The genot...
Chernobyl as a natural laboratory: Genetic instability, adaptation, and ecological recovery in flora and fauna under chronic radiation [0.03%]
切尔诺贝利的生态效应：辐射慢性暴露下植物和动物的遗传不稳定、适应及生态恢复
Gulsah Yildiz Deniz
Gulsah Yildiz Deniz
The Chernobyl nuclear accident of April 1986 remains the most severe nuclear disaster in human history, with long-lasting consequences for ecosystems exposed to chronic ionizing radiation. In the decades since the event, the Chernobyl Exclu...
Frequency of γ-H2AX foci, micronucleus formation, and radiation dose to the blood lymphocytes in pediatric and adult participants underwent computed tomography imaging [0.03%]
儿童和成人CT检查受检者外周血淋巴细胞辐射剂量及γ-H2AX焦点和微核形成频率分布特点研究
Divya K Mohan,Nandhini K,Aishwarya S et al.
Divya K Mohan et al.
Computed tomography (CT) is a widely used diagnostic imaging modality that contributes significantly to human healthcare. Despite the advantage, its extensive use increased concerns due to receiving radiation doses to pediatric patient's ov...
DNA damage and nuclear anomalies in peripheral blood lymphocytes from asthma patients and obese individuals [0.03%]
哮喘患者和肥胖人群外周血淋巴细胞中的DNA损伤及核异常
Aswathi Pootheri,Medha Nagaraj,Nethra Raghuraman et al.
Aswathi Pootheri et al.
Asthma is a chronic, non-communicable respiratory disorder affecting approximately 262 million people worldwide, with India projected to become one of the leading countries in prevalence. Asthma is well-established as a condition of chronic...
Evidence of erythropoiesis rather than direct genotoxicity causing micronucleus induction by a new protoporphyrinogen-oxidase inhibitor [0.03%]
一种新型原卟啉原氧化酶抑制剂诱导微核形成的原因是溶血性贫血而不是直接遗传毒性证据
Naveed Honarvar,Astrid Zander,Miyuki Shigano et al.
Naveed Honarvar et al.
Protoporphyrinogen-oxidase inhibitors (PPOi) are a class of herbicides that target chlorophyll synthesis in plants. Similarly, they affect heme synthesis in mammals, resulting in anemia. A new PPOi development candidate showed micronucleus ...
Protective role of Cockayne Syndrome B (CSB) protein in maintaining genome integrity in human cells under oxidative stress [0.03%]
氧化应激下CSB蛋白在维持人类细胞基因组稳定性中的作用
Grace Kah Mun Low,Gavin Yong-Quan Ng,Dimphy Zeegers et al.
Grace Kah Mun Low et al.
Cockayne Syndrome (CS), a progeroid disorder characterised by premature ageing and neurodevelopmental abnormalities, is primarily caused by mutations in the CSB protein, a key component of the transcription-coupled nucleotide excision repai...
Genotoxicity mode of action exploration of polyethylene glycol terephthalate (PET) acetic acid migration solution under repeated-dose exposure in rats [0.03%]
PET醋酸迁移溶液重复给药染毒大鼠的遗传毒性作用机制研究
Liang Wang,Li Cao,Xiaoya Wang et al.
Liang Wang et al.
As a commonly used material that contacts food, polyethylene glycol terephthalate (PET) may interact with food, and since certain components can migrate, this has become a food safety concern. This study aims to investigate the genotoxicity...
Protective effects of nicotinamide mononucleotide on DNA damage and cell death in A549 cells and aging in C. elegans caused by hydrogen peroxide [0.03%]
烟酸单核苷酸对H2O2诱导的DNA损伤和细胞凋亡以及秀丽隐杆线虫衰老的影响研究
Chuncao He,Xueying Sun,Ting Xu et al.
Chuncao He et al.
Oxidative stress is a major factor for aging. Nicotinamide mononucleotide (NMN) is a naturally occurring bioactive nucleotide and a precursor for nicotinamide adenine dinucleotide (NAD+), and accumulating evidences have shown that NMN is a ...
Perchloroethylene: Genotoxicity and cytotoxicity in human peripheral blood lymphocytes in vitro [0.03%]
四氯乙烯体外人类外周血淋巴细胞的遗传毒性和细胞毒性
Tülay Aşkın Çelik,Ümit Ünsal
Tülay Aşkın Çelik
Perchloroethylene (PCE), a widely used solvent, is classified as a probable human carcinogen. We have studied its genotoxicity, clastogenicity, and cytotoxicity in cultured human peripheral lymphocytes (HPLs). Cytogenetic tests used were th...