Chromosome malsegregation induced by methanol in Drosophila melanogaster females [0.03%]
甲醇致果蝇雌性个体染色体不分离
Ana María Palermo,Eliana Ruth Steinberg,Marta Dolores Mudry
Ana María Palermo
Methanol (MeOH) is a colorless, flammable, poisonous, alcohol that causes intoxication by ingesting, inhaling or by contact with formulations that include it. It is produced in large volumes and there is high level of human exposure, especi...
Integrated assessment of metal bioaccumulation and genotoxic biomarkers in blood of broad-snouted caiman (Caiman latirostris) from Northeastern Brazil [0.03%]
东北巴西宽吻凯门鳄血液中金属生物积累和遗传毒性生物标志物的综合评估
Rayssa Lima Dos Santos,Mônica Lúcia Adam,Ednilza Maranhão Dos Santos et al.
Rayssa Lima Dos Santos et al.
Environmental contamination by heavy metals poses a significant threat to aquatic biodiversity, however, the genotoxic effects in reptiles remain poorly understood, particularly in tropical ecosystems. This study provides the first genotoxi...
Effect of apigenin against Bis(2-ethylhexyl) phthalate induced toxicity on Drosophila melanogaster [0.03%]
芹菜素对Bis(2-乙基己基)磷酸酯诱导的果蝇(Drosophila melanogaster)毒性的改善作用
Kajal Gaur,Yasir Hasan Siddique
Kajal Gaur
Bis(2-ethylhexyl) phthalate (DEHP) is a widely used synthetic compound known for its significant environmental and health hazards. It is particularly recognized for disrupting cellular functions by interfering with endocrine activity and in...
Limited concordance between micronucleus and chromosomal aberration assays in medical radiation workers: Evidence from a tertiary hospital-based study [0.03%]
基于三甲医院的医学辐射工作人员微核试验和染色体畸变检测的一致性研究证据
Gaiyan Du,Zhenxin Guo,Jingyi Wu et al.
Gaiyan Du et al.
Background: The cytokinesis-block micronucleus (CBMN) assay is widely used for biomonitoring populations exposed to ionizing radiation as a simpler alternative to the chromosomal aberration (CA) assay. However, evidence r...
Toxicity and genotoxicity of AlCl3 in transgenic Drosophila melanogaster (hsp-70 lacZ) Bg9 [0.03%]
AlCl3的毒性及其在转基因果蝇Bg9(hsp-70 lacZ)体内的诱变效应
Iqra Subhan,Tanishka Gupta,Kajal Gaur et al.
Iqra Subhan et al.
Drosophila melanogaster third-instar larvae were exposed to AlCl₃ in the diet for 24 h. Dose-dependent reductions in pupation and adult emergence were observed, Biochemical analyses revealed significantly elevated oxidative stress markers:...
Genotoxic and cytotoxic effects of dietary patterns and lifestyle factors: A cross-sectional comparison of Brazilian and Spanish gym users [0.03%]
饮食模式和生活习惯的致基因毒性和细胞毒性：巴西和西班牙健身房用户的横断面比较
Diene da Silva Schlickmann,Gabriela Cristina Uebel,Patrícia Molz et al.
Diene da Silva Schlickmann et al.
This cross-sectional study evaluated dietary and lifestyle factors potentially contributing to DNA damage, cytokinetic defects, proliferative potential, and cell death among gym users in Brazil and Spain. We assessed demographic data, exerc...
Selection of tests for genotoxicity assessment: Sensitivity and specificity considerations [0.03%]
致突变试验的选择：灵敏度与特异性的考量
Makoto Hayashi,Takashi Omori
Makoto Hayashi
The appropriate strategy for a genotoxicity assessment depends on the purpose of the study. If the purpose is research-oriented (for example, to understand mechanisms of gene-mutation events or chromosomal aberrations), the tests should mee...
The potential implications of dysregulated DNA damage repair genes and their modulators as adjuvants for current chemotherapy regimens in Retinoblastoma tumors [0.03%]
染色体损伤修复基因及其调节因子在视网膜母细胞瘤治疗中的潜在影响及作用机制研究
Keya Katare,Rohit Shetty,Arkasubhra Ghosh
Keya Katare
Retinoblastoma (RB) is the most common pediatric ocular malignancy resulting from biallelic inactivation of the RB1 gene and can be fatal if not treated. With advances in chemotherapy and earlier diagnosis, the mortality rates in developed ...
Mutagenicity of nitrosamines in enhanced Ames tests: A review of strain, metabolism, and solvent effects [0.03%]
增效Ames试验中硝胺致突变性的再评价：对菌株、代谢和溶剂效应的回顾性研究
Samit B Kadam,M R Mayookh,N Bhumika et al.
Samit B Kadam et al.
We review the results of the 'Enhanced' Ames Test (EAT) for assessment of the mutagenicity of N-nitrosamines, integrating the data from six key studies. High (>98 %) purities of the nitrosamines were confirmed by LC-MS and glutathione co-in...
Cellular uptake, induction of reactive oxygen species, and genotoxicity of differently sized cobalt oxide nanoparticles in human peripheral blood mononuclear cells in vitro [0.03%]
体外钴氧化物纳米颗粒的细胞摄取、活性氧生成及遗传毒性研究——基于人类外周血单个核细胞
Milda Babonaitė,Veronika Dedonytė,Emilija Striogaitė et al.
Milda Babonaitė et al.
Cobalt (II, III) oxide nanoparticles (Co3O4-NPs) have potential applications in different technological and medical fields, including drug delivery and as novel anticancer treatments. However, widespread application could lead to a high-lev...