Development and analysis of the adverse outcome pathway network for neurotoxicity [0.03%]
神经毒性的不良结局路径网络的构建与分析
Xinyue Hui,Xingying Li,Sisi Liu et al.
Xinyue Hui et al.
Adverse Outcome Pathways (AOPs) and their networks offer a structured framework for understanding toxicological mechanisms and supporting non-animal testing strategies. This study developed a neurotoxicity-focused AOP network (NT-AOPn) base...
NOX4/Keap1/Nrf2/ROS Signaling Drives Ferroptosis in Trimethyltin Chloride-Induced Cardiac Developmental Malformations [0.03%]
NOX4/Keap1/Nrf2/ROS信号驱动的一氧化氮四氯化物致心脏发育畸形的铁死亡发生
Jin Chen,Hanwen Hu,Jing Fu et al.
Jin Chen et al.
Trimethyltin chloride (TMT), a pervasive environmental organic tin pollutant, has been implicated in cardiac injury, though its underlying mechanisms remain unclear. TMT exposure triggers excessive reactive oxygen species (ROS) generation, ...
Bisphenol AP promotes pulmonary fibrosis by regulating macrophage function in a bleomycin-induced mouse model [0.03%]
双酚A通过调节促炎巨噬细胞功能促进博来霉素诱导的小鼠肺纤维化进展
Ze Chen,Zhenying Lin,Meng Ni et al.
Ze Chen et al.
Bisphenols are extensively used in industrial and consumer products and may pose potential risks to human health. Previous studies have shown that bisphenol A (BPA) induces chronic inflammation and lung toxicity. Bisphenol AP (BPAP), a stru...
In vivo high-throughput toxicity screening of brominated flame retardants using a Caenorhabditis elegans transcription factor RNAi platform [0.03%]
基于秀丽隐杆线虫转录因子RNAi平台的溴系阻燃剂体内高通量毒性筛查
Siyeol Ahn,Elizabeth Dufourcq Sekatcheff,Jinhee Choi
Siyeol Ahn
Brominated flame retardants (BFRs) such as tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCDD), and decabromodiphenyl ethane (DBDPE) are extensively used in a variety of consumer products, including electronics, textiles, and furn...
Bisphenol TMC exhibits greater estrogenic activity than Bisphenol A and three other structural analogues exemplified by higher estrogen receptor α-mediated gene expression and breast cancer cell proliferation [0.03%]
双酚TMC比双酚A及其他三种结构类似物展现出更强的雌激素活性：更高雌激素受体α介导的基因表达和乳腺癌细胞增殖
Friedrich L Joos,Rianne E van Diest,Martin Smieško et al.
Friedrich L Joos et al.
Bisphenol A (BPA) and its structural analogues are widely used in plastics production, raising concern due to endocrine-disrupting properties. While many analogues share structural similarities with BPA, their endocrine-disrupting effects r...
Mechanistic Insights into TDCPP-Induced DNA Damage in GT1-7 Cells [0.03%]
TDCPP诱导的小鼠睾丸GT1-7细胞DNA损伤的机制研究
Bingli Lei,Jiaying Li,Yingxin Yang et al.
Bingli Lei et al.
As a typical organophosphate ester compound, tris(1,3-dichloro-2-propyl) phosphate (TDCPP) exhibits both estrogenic activity and genotoxicity. However, the involvement of estrogen signaling pathways in TDCPP-induced genotoxicity remains unc...
Maternal Exposure to Polypropylene Nanoplastics Disrupts Sex- and Region-Specific Lipid Metabolism in the Brains of C57BL/6N Mouse Offspring [0.03%]
母体暴露于聚丙烯纳米塑料会扰乱C57BL / 6N小鼠后代大脑中的性别和区域特异性脂质代谢
Jangjae Lee,Subin Park,Da Yong Lee et al.
Jangjae Lee et al.
Polypropylene nanoplastics (PPNPs), produced through the degradation of widely used plastic products, are increasingly recognized as emerging environmental contaminants with potential neurodevelopmental toxicity. However, the long-term bioc...
Cx43 Phosphorylation at Ser368 Facilitates PASMC Dedifferentiation in Nicotine-Induced Pulmonary Arterial Remodeling [0.03%]
尼古丁致肺动脉重塑时促进PASMC去分化的缝隙连接蛋白Cx43的Ser368磷酸化
Yi Xu,Xiaomin Hou,Su Guo et al.
Yi Xu et al.
Background: Pulmonary arterial hypertension is a severe disease characterized by pulmonary vascular remodeling, which is closely associated with the phenotypic switching of pulmonary artery smooth muscle cells (PASMCs). C...
Nickel refining fumes Activate Glutamine Metabolism via the HIF-1α/Notch Pathway to Drive Epithelial-Mesenchymal Transition in Beas-2B Cells [0.03%]
镍烟尘通过HIF-1α/Notch信号激活谷氨酰胺代谢促进Beas-2B细胞上皮间质转化
Qian-Qian Sun,Han-Nong Yu,Rui-Ze Wu et al.
Qian-Qian Sun et al.
Occupational exposure to nickel refining fumes (NiRF) represents a critical risk factor for respiratory diseases; however, the molecular mechanisms governing NiRF-induced epithelial-mesenchymal transition (EMT) in bronchial epithelial cells...
Macrophage-epithelial cells crosstalk and the role of CCL2-CCR2 axis in single-walled carbon nanotubes-induced lung inflammation and fibrosis [0.03%]
巨噬细胞上皮细胞相互作用及CCL2-CCR2轴在单壁碳纳米管致肺部炎症和纤维化中的作用
Yalu Shen,Zhen Shi,Jiayang Zou et al.
Yalu Shen et al.
Environmental and occupational exposure to carbon nanotube (CNT) raises concerns over their safety and adverse health impacts, especially lung inflammation and fibrosis. Immune cells and epithelial cells within alveoli interact with each ot...