Micro-nanoplastics in the central nervous system: evidence, mechanisms and perspectives [0.03%]
微塑料和纳米塑料与中枢神经系统：证据、机制及展望
Zhexun Pei,Hang Zhong,Xiaoqing Li et al.
Zhexun Pei et al.
Environmental exposure to micro-nanoplastics (MNPs) has emerged as a significant concern for neurological health. This review synthesizes evidence that MNPs translocate the blood-brain barrier (BBB) and induce neurotoxicity through mechanis...
PFOS promotes Alzheimer's disease through aggravating the cell apoptosis and AKT/GSK3β/NF-κB/NLRP3 pathway mediated inflammation [0.03%]
PFOS通过促进细胞凋亡和Akt/GSK3β/NF-κB/NLRP3通路介导的炎症来促进阿尔茨海默病的发展
Ming Li,Xianhao Ping,Huixin Song et al.
Ming Li et al.
Perfluorooctane sulfonate (PFOS) and its alternatives are widely utilized in industrial and commercial applications. Nevertheless, their environmental persistence and widespread detection in diverse matrices in recent years have raised sign...
ROS-Driven Rewiring of Hippo-Inflammation-Polycomb Axis by PFOA in 2D and 3D Lung Epithelial Models [0.03%]
全氟辛酸通过二维和三维肺上皮模型重编程Hippo-炎症-Polycomb轴的分子机制研究
M Thakur,D Mutyala,A A Amoliga et al.
M Thakur et al.
Perfluorooctanoic acid (PFOA), a persistent organic pollutant and prominent member of the per- and polyfluoroalkyl substances (PFAS) family, continues to raise global concern due to its bioaccumulation and potential for chronic human exposu...
Toxicological effects of PM2.5-derived and PM2.5-relevant mixture of chlorinated paraffins on A549/THP-1 co-culture cells [0.03%]
PM2.5衍生氯化石蜡对A549/THP-1共培养细胞的毒理学效应研究
Jing-Wen Huang,Chu Chu,Mo Yang et al.
Jing-Wen Huang et al.
Chlorinated paraffins (CPs) are complex mixture of chlorinated straight-chain hydrocarbons, including short-, medium-, and long-chain CPs (SCCPs, MCCPs, and LCCPs), to which humans are exposed environmentally. Although PM2.5-bound CPs were ...
Physiologically relevant 3D CRISPR screening enhances mechanistic insight into chemical toxicity compared to 2D screening [0.03%]
与二维筛选相比，生理相关的三维CRISPR筛选能够增强对化学毒性的机制理解
Chanhee Kim,Zhaohan Zhu,Abderrahmane Tagmount et al.
Chanhee Kim et al.
CRISPR-based approaches can complement other genomics-based toxicology studies by enabling causal interrogation of gene function modulating chemical-induced toxicity. Moreover, CRISPR screens enable scalable and systematic identification of...
A Comparative Toxicological Evaluation of Nicotine and Its Analog 6-Methyl Nicotine in E-Cigarette Aerosol Utilizing a 3D in vitro Human Respiratory Model [0.03%]
利用三维体外人体呼吸道模型比较电子烟气溶胶中尼古丁及其类似物6-甲基尼古丁的毒理学评价
Felix Effah,Mohana Sengupta,Yehao Sun et al.
Felix Effah et al.
Under the U.S. Tobacco Regulatory Act of 2020, all novel nicotine-containing products require a Premarket Tobacco Product Application (PMTA) and FDA authorization before they can be marketed. However, lengthy PMTA review timelines have prom...
Nanoplastics induce SH-SY5Y cell damage through oxidative stress and disruption of amino acid metabolism [0.03%]
纳米塑料通过氧化应激和干扰氨基酸代谢诱导SH-SY5Y细胞损伤
Tianyi Ma,Yuyang Liu,Jingran Sun et al.
Tianyi Ma et al.
With the pervasive environmental distribution of plastics, their fragmentation into nanoplastics (NPs) has raised growing concerns regarding potential biological toxicity, particularly in neuronal cells. This study investigated the toxic ef...
Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression [0.03%]
砷化物通过干扰硒代谢并降低GPx4表达来使细胞对铁死亡敏感
Hayato Takashima,Reiko Makino,Hiroki Taguchi et al.
Hayato Takashima et al.
Arsenic (As), an environmental toxicant commonly found in groundwater, exerts its toxic effects primarily through oxidative stress. Selenium (Se) plays a crucial role in counteracting oxidative stress by promoting the synthesis of Se-contai...
Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid models [0.03%]
持久性有机污染物：神经毒性机制及其类器官模型的启示
Ziyu Ji,Liqun Chen,Dong Ming
Ziyu Ji
Persistent Organic Pollutants (POPs) pose significant global environmental health risks due to their persistence, bioaccumulation, and long-range transport. Exposure to POPs has been linked to a range of neurological disorders, including co...
Cigarette smoke exposure disrupts the blood-testis barrier and negatively impacts reproductive capacity in mice [0.03%]
烟草烟雾暴露破坏小鼠血睾屏障并影响其生殖能力
Yuan Zhong,Xueyu Wei,Zimangul Yasin et al.
Yuan Zhong et al.
Maintaining normal testicular structure and function is closely related to the blood-testis barrier (BTB). Meanwhile, cigarette smoke extract (CSE) affects testicular function. However, whether CSE mediates BTB damage and the underlying mec...