In vitro inhibition of monoamine transport by amphetamine-like pre-workout supplement ingredients [0.03%]
类似苯丙胺的运动前补充剂成分对单胺再摄取的体外抑制作用
Nicole E T Pinckaers,Paulina D Sawicka,J Pepijn Wopken et al.
Nicole E T Pinckaers et al.
Phenethylamine (PEA) and alkylamine (AA) analogues are a prominent group of pre-workout food supplement ingredients. They are structurally related to the stimulant amphetamine and to the endogenous catecholamines noradrenaline and dopamine,...
Fertility decline induced by subchronic exposure to an atrazine-mesotrione mixture in male Wistar rats [0.03%]
三氯吡嗤隆和百草枯混合物亚慢性暴露对雄性Wistar大鼠生育力的影响
Luiz Otávio Guimarães-Ervilha,Izabela da Silva Lopes,Mírian Quintão Assis et al.
Luiz Otávio Guimarães-Ervilha et al.
A commercial atrazine-mesotrione mixture (Calaris®) is widely used in agriculture due to its improved weed control. However, toxicological data on this combination remain elusive, especially regarding its effects on mammalian health. Herei...
Redox Imbalance and Glutathione Metabolism Disruption Drive Neodymium - Induced Neurotoxicity in Microglia [0.03%]
氧化还原失衡和谷胱甘肽代谢紊乱驱动钕诱导的小胶质细胞神经毒性
Jinglin Wang,Xutong Qin,Longfei Feng et al.
Jinglin Wang et al.
Neodymium (Nd), a rare earth element widely used in clean energy and electronic technologies, has raised increasing concern for its potential neurotoxic effects. Microglia, the primary immune cells of the central nervous system, are particu...
Bridging AI Advancements with Risk Assessment Needs: A Journey Towards Effective Use and Regulatory Acceptance [0.03%]
人工智能进展与风险评估需求的融合：迈向有效应用和监管认可之旅
Serhii Kolesnyk,Joyce de Paula Souza,Angela Bearth et al.
Serhii Kolesnyk et al.
In recent years, the development of artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has not only captured the attention of scientists, industry, and society due to its vast potential, but also sparked d...
Ben Cools,Mathieu Vinken
Ben Cools
Proquinazid, a new-generation fungicide, induces DNA damage and apoptosis via oxidative stress process in liver and kidney tissues of adult Wistar rats [0.03%]
新型杀菌剂丙森锌可通过氧化应激过程诱导成年Wistar大鼠肝肾组织DNA损伤及凋亡
Siwar Rich,Karima Rjiba,Imen Ayed et al.
Siwar Rich et al.
Proquinazid (PROQ) is a new fungicide used against powdery mildew infections, but little is known about PROQ toxicity. The aim of this study was to investigate the effects of PROQ in liver and kidney. Male Wistar rats were daily exposed for...
Polystyrene nanoplastics disrupt iron homeostasis by promoting FPN1 ubiquitination in GC-2spd(ts) cells [0.03%]
聚苯乙烯纳米塑料通过促进FPN1泛素化扰乱GC-2spd(ts)细胞铁稳态
Xinru Cui,Yitong Shang,Liyang Ding et al.
Xinru Cui et al.
Nanoplastics are emerging environmental pollutants ubiquitously found in natural ecosystems. Although studies have shown that nanoplastics can accumulate in the testes of mice and affect spermatogenic cells, the specific toxicological mecha...
Cl-PFESA disrupts thyroid hormone secretion in human thyrocytes and nonmonotonic effects of iodide co-exposure [0.03%]
Cl-PFESA干扰人类甲状腺细胞的甲状腺激素分泌及碘共暴露的非单调效应
Mengying Teng,Jianhui Zhuang,Lili Yang et al.
Mengying Teng et al.
Chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs, F-53B) are widespread environmental pollutants that have been introduced as emerging alternatives to perfluorooctane sulfonate. They are suspected to have thyroid-disrupting effec...
Prenatal Arsenic Exposure and Gene Expression in Fetal Liver, Heart, Lung, and Placenta [0.03%]
孕期砷暴露与胎儿肝脏、心脏、肺和胎盘基因表达的关系
Kristal A Rychlik,Sylvia Sanchez,Chloe Kashiwagi et al.
Kristal A Rychlik et al.
Prenatal arsenic exposure has been linked to a myriad of negative health effects. There is relatively little insight into the mechanisms and signaling alterations across different fetal organs that drive long-term immune-related issues foll...
Microplastic-Induced Alterations in the Intestinal Environment: Aging as a Modulating Factor [0.03%]
微塑料引起的肠道环境变化：衰老作为调节因素
Alicia Sánchez,Diego Ríos,Mireia Mártinez et al.
Alicia Sánchez et al.
Microplastics (MPs) present in the diet can affect the intestinal environment. Alterations in gut microbiota, as well as oxidative stress and inflammation in intestinal tissue, have been reported. However, most studies rely on commercial mi...