Long-Term Low-Dose Exposure to Polystyrene Nanoplastics Induces Morphological and Transcriptional Reprogramming to Enhance Metastatic Potential of Colorectal Cancer Cells [0.03%]
长期低剂量接触聚苯乙烯纳米塑料可诱导结直肠癌细胞向转移表型重编程
Yeongjae Kim,Seon Yeong Park,Ahyoung Jo et al.
Yeongjae Kim et al.
Despite global efforts to reduce plastic consumption, its usage continues to rise, leading to increased environmental contamination and heightened concerns regarding the potential health impacts of nanoplastics. Owing to their prolonged res...
Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/STAT pathways [0.03%]
棕榈酸在HepaSH芯片模型中诱导脂毒性并提高H2O2和IL-6的水平，并改变p38 / MAPK和JAK / STAT通路
Hanyuan Wang,Stéphane Poulain,Wenxin Cao et al.
Hanyuan Wang et al.
Hepatic inflammation induced by lipotoxicity is a key event in the progression of liver steatosis to non-alcoholic steatohepatitis (NASH). To characterize this process, we investigated the response of HepaSH cells-a novel mature human hepat...
In vitro and in vivo thyroid hormone system disruption by perfluorooctane sulfonate (PFOS) and tetrabromobisphenol A (TBBPA) [0.03%]
全氟辛烷磺酸(PFOS)和四溴双酚A(TBBPA)的体内外甲状腺激素干扰作用
Mette Stub,Lars Dahmen,Agnieszka A Niklas et al.
Mette Stub et al.
Thyroid hormone (TH) system-disrupting chemicals can cause adverse effects, including neurodevelopmental deficits. While current in vivo test methods reliably detect disruptions from potent antithyroid drugs such as propylthiouracil (PTU) a...
Retraction notice to "2,3,7,8-Tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line" [Toxicology 290 (2011) 258-270] [0.03%]
撤稿通知：“2,3,7,8-四氯二苯并对二噁英诱导牛肾细胞系自噬”[毒理学290(2011)258-270]
Filomena Fiorito,Roberto Ciarcia,Giovanna Elvira Granato et al.
Filomena Fiorito et al.
Published Erratum
Toxicology. 2025 Nov 20:154330. DOI:10.1016/j.tox.2025.154330 2025
Impact of fluoride on antioxidant activity and mitochondrial homeostasis in fetal rat kidney [0.03%]
氟对大鼠胎肾抗氧化活性和线粒体稳态的影响
Sabino Hazael Avila-Rojas,Esaú Montañez-Rodriguez,Ana Karen Pantaleón-Gómez et al.
Sabino Hazael Avila-Rojas et al.
Fluoride exposure harms human health. Additionally, recent attention has focused on understanding the impact of an adverse in utero environment on the programming of chronic kidney disease in adult offspring. A previous study has described ...
The combined exposure to AFB1 and DON induces the ferroptosis of porcine intestinal epithelial cells via down-regulating PI3K-AKT signal pathway [0.03%]
黄曲霉毒素B1和脱氧雪腐镰刀菌烯醇通过下调PI3K-AKT信号通路诱导猪小肠上皮细胞铁死亡的联合暴露效应
Wenshuo Zhao,Qirui Yang,Yuqi Song et al.
Wenshuo Zhao et al.
Aflatoxin B1 (AFB1) and deoxynivalenol (DON) are two highly hazardous mycotoxins often coexisting in feed, threating animal intestinal health. Ferroptosis, a regulated cell death linked to iron metabolism disorders, lipid peroxidation, and ...
Combined exposure to polystyrene nanoplastics and bisphenol A results in mitochondrial damage and ferroptosis via the PI3K-AKT signaling pathway in mice kidneys [0.03%]
聚苯乙烯纳米塑料和双酚A联合暴露通过PI3K-AKT信号通路导致小鼠肾脏线粒体损伤和铁死亡
Qimeng Wang,Yinghui Wang,Ying Wang et al.
Qimeng Wang et al.
Nanoplastics (NPs), a growing environmental concern, can act as carriers for co-pollutants like bisphenol A (BPA). Consequently, understanding the combined toxicity of these pollutants is critical, as mammals are often exposed to multiple e...
Mechanistic insights into the structure-toxicity relationship of α-aminononanophenone derivatives: role of CYP3A4 and oxidative stress [0.03%]
α-氨基壬基苯酮衍生物的结构毒性关系机制见解：CYP3A4和氧化应激的作用
Yoshifumi Morikawa,Nozomi Azuma,Yuji Sakai et al.
Yoshifumi Morikawa et al.
Continuous abuse and overdose of aminophenone derivatives, a representative group of synthetic cathinones, are known to exhibit severe damage against neuronal cells, whereas little is known about their structure-toxicity relationship and cy...
Hydramethylnon-induced autophagy and apoptosis in human bronchial epithelial cells by homeostatic changes [0.03%]
氢甲基蚊菊酯通过细胞稳态变化诱导人支气管上皮细胞自噬和凋亡
Yeon-Ho Kang,Sou Hyun Kim,Hye-Jin Jeong et al.
Yeon-Ho Kang et al.
Household chemicals are commonly used products worldwide; however, their effects on human respiratory health are poorly understood. In this study, we aimed to investigate the effects of hydramethylnon (HDM), an insecticide frequently found ...
Ardie Barry Sailis,Muhamad Alfakri Bin Mat Noh,Bey Fen Leo et al.
Ardie Barry Sailis et al.
E-cigarette use has been linked to mitochondrial dysfunction through exposure to reactive oxygen species (ROS), toxic aldehydes, metals, and flavoring agents. These constituents can damage mitochondrial DNA, impair oxidative phosphorylation...