Polystyrene microplastics induce skeletal muscle atrophy through disruption of anabolic signaling and mitochondrial function [0.03%]
聚苯乙烯微塑料通过扰乱合成信号传导和线粒体功能诱导骨骼肌萎缩
Soo-Young Choi,Jiyoung Yeo,Yu-Jin Heo et al.
Soo-Young Choi et al.
Polystyrene microplastics (PS-MPs) have emerged as pervasive environmental contaminants with growing concerns regarding their potential adverse effects on human health; however, their impact on skeletal muscle homeostasis remains poorly und...
Silica-induced telomere dysfunction promotes pulmonary fibrosis through the activation of the cGAS-STING pathway [0.03%]
二氧化硅诱导的端粒功能不全通过活化cGAS-STING信号通路促进肺纤维化
Qiuqian Qian,Simiao Pan,Xiaodong Li et al.
Qiuqian Qian et al.
Objective: This study aims to elucidate whether silica (SiO₂) induces alveolar epithelial cell senescence through telomere shortening, and to explore the involvement of TERF1 and its subsequent activation of the cGAS-STI...
Exposure to microplastics and liver oncogenesis: A comprehensive review on molecular mechanisms and pathogenic pathways [0.03%]
微塑料暴露与肝致癌：分子机制和致病途径的全面综述
Wangying Li,Zhaoan Wang,Jiongfei Chen et al.
Wangying Li et al.
Microplastics have become a serious environmental pollutant that enter different ecosystems and eventually the human body through direct exposure to the environment. This infiltration is a major health risk, especially for the liver, which ...
Epigenetic approaches by analysis of circulating miRNAs and global DNA methylation in veterinarians occupationally exposed to volatile anesthetics [0.03%]
乙酰胆碱酯酶抑制剂中毒的microRNA和DNA甲基化表观遗传学研究
Tony Fernando Grassi,Mariane Aparecida Pereira Silva,Maria Vitória Destro et al.
Tony Fernando Grassi et al.
Exposure to waste anesthetic gases (WAGs) is an underestimated occupational hazard in veterinary operating rooms (VORs), where insufficient ventilation and the absence of scavenging systems remain common worldwide. Veterinarians occupationa...
Co-exposure to polystyrene nanoplastics and cadmium induces apoptosis in intestinal cells: Role of the IP3R/Ca²⁺/STAT3 signaling pathway [0.03%]
聚苯乙烯纳米塑料和镉共暴露通过IP3R/Ca²⁺/STAT3信号通路诱导肠道细胞凋亡
Haitao Yang,Liqing Wu,Shuyan Niu et al.
Haitao Yang et al.
The widespread use of plastic products has elevated nanoplastics (NPs) pollution to a critical global concern, with polystyrene nanoplastics (PS-NPs) and cadmium (Cd) emerging as common environmental contaminants whose co-occurrence and com...
Keratinocytes exposed to Ozone induce a bystander oxinflammatory response in dermal fibroblasts [0.03%]
臭氧暴露角质细胞通过旁观者效应诱导真皮成纤维细胞炎性反应
Mariáurea Matias Sarandy,Anna Guiotto,John Ivarsson et al.
Mariáurea Matias Sarandy et al.
While ozone (O₃) is widely recognized for its respiratory effects and its detrimental impact on skin health has been well demonstrated, the mechanisms underlying dermal damage remain incompletely understood. This study investigates the bio...
Polyvinyl chloride microplastics exposure accelerates endometrial cancer progression via regulating AHR/CYP1A1 signaling pathway [0.03%]
聚氯乙烯微塑料通过调节AhR/CYP1A1信号通路加速子宫内膜癌进展
Liping Zhang,Dezhao Chen,Rencai Fan et al.
Liping Zhang et al.
Endometrial cancer (EC) is one of the most prevalent gynaecological cancers among women. Despite the advent of advanced therapeutic approaches, the mortality rate of EC has not declined but rather shows an increasing trend, which is closely...
Yuke Xu,Mengjie Liu,Jiashe Chen et al.
Yuke Xu et al.
Mycotoxins are widespread toxic secondary metabolites produced by fungi, posing substantial health risks to humans and animals. Recent studies have highlighted the crucial role of autophagy in mediating mycotoxin-induced toxicity. As a high...
Mitochondrial toxicity of emerging disinfection byproduct 2,6-dichloro-1,4- benzoquinone in renal proximal tubule cells: Oxidative phosphorylation impairment and metabolic reprogramming [0.03%]
新型消毒副产物2,6-二氯-1,4-苯醌对肾近端小管细胞线粒体毒性：氧化磷酸化障碍和代谢重编程
Yawen Chen,Ting Xu,Limei Gu et al.
Yawen Chen et al.
2,6-Dichloro-1,4-benzoquinone (DCBQ), an emerging aromatic disinfection byproduct (DBP) frequently detected in drinking water, has raised increasing concern regarding its potential renal toxicity. However, its toxic effects at environmental...
Nicotine drives acute epithelial injury in region-specific human airway models at the air-liquid interface after e-cigarette aerosol exposure [0.03%]
尼古丁驱动的电子烟气溶胶暴露后液-气界面特定区域人体呼吸道模型上急性上皮损伤
Ozge Kose,Clément Mercier,Jérémie Pourchez
Ozge Kose
Electronic cigarette aerosols are complex mixtures whose respiratory toxicity depends on formulation chemistry and regional deposition. This study investigated how nicotine presence, nicotine protonation state, and propylene glycol/vegetabl...