Endocrine and metabolism modulating effects of paracetamol: From in vitro signaling to in vivo metabolic reprogramming in male mice [0.03%]
对乙酰氨基酚的内分泌和代谢调节作用：从体外信号传导到雄性小鼠中的体内代谢重编程
Bita Entezari,Deniz Bozdag,Aylin Buhur et al.
Bita Entezari et al.
Obesity is a major global health challenge associated with a cluster of comorbidities, including metabolic syndrome and type 2 diabetes, necessitating a deeper understanding of the environmental factors contributing to this epidemic. This s...
A semi-automated workflow to quantify γ-H2AX DNA damage in pulmonary cell models and lung tissue sections [0.03%]
一种半自动工作流程，用于量化肺细胞模型和肺组织切片中的γ-H2AX DNA损伤
Maëva Cherriere,Myriam Oger,Suzanne De Araujo et al.
Maëva Cherriere et al.
The quantification of DNA double-strand breaks via γ-H2AX immunolabeling is a cornerstone of genotoxicity assessment, yet classical nucleus-based counting is frequently constrained by cell morphology, high confluence, and complex tissue ar...
Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation [0.03%]
NR2F6表达降低重塑了VPA诱导的肝细胞转录组并增加脂质积累
Kaidi Guo,Marcha Verheijen,Marcel van Herwijnen et al.
Kaidi Guo et al.
Valproic acid (VPA) is an antiepileptic drug associated with hepatic steatosis, yet the transcriptional regulators determining cellular susceptibility to VPA remain incompletely defined. In a time-series RNA-sequencing analysis of primary h...
Application of HepaRG mono- and HepaRG:THP-1 cocultures as immune responsive hepatotoxicity models [0.03%]
HepaRG单层和HepaRG:THP-1共培养体系在免疫响应型肝毒性模型中的应用研究
Gijs J J van Slobbe,Mathias Busch,Wouter Bakker et al.
Gijs J J van Slobbe et al.
Embedding immune responsiveness is relevant for hepatotoxic testing strategies, as inflammation can affect the kinetics of compounds by modulation of drug-metabolizing enzymes and transporters (DMETs), and because inflammation is thought to...
POLA1 mediates hexavalent chromium-induced ovarian tumor progression through replication stress and DNA damage response [0.03%]
POLA1通过复制压力和DNA损伤反应介导六价铬诱导的卵巢肿瘤进展
Haoran Guo,Zeqing Sun,Mengzhen Li et al.
Haoran Guo et al.
Hexavalent chromium (Cr(VI)), a recognized environmental carcinogen, yet its role in promoting gynecological malignancies remains mechanistically unclear. Here, we demonstrate that chronic, low-dose hexavalent chromium (Cr(VI)) exposure (0....
Corrigendum to: "Benzo[a]pyrene exposure promotes RIP1-mediated necroptotic death of osteocytes and the JNK/IL-18 pathway activation via generation of reactive oxygen species" [Toxicology, 476, June 2022, 153244] [0.03%]
关于“苯并[a]芘暴露通过生成活性氧促进成骨细胞坏死性凋亡及JNK/IL-18通路活化”的勘误注释
Tao Zhang,Yuchen Shen,Ruirong Zhu et al.
Tao Zhang et al.
Published Erratum
Toxicology. 2026 Mar 28:154455. DOI:10.1016/j.tox.2026.154455 2026
Response to the Letter to the Editor regarding "Nicotine drives acute epithelial injury in region-specific human airway models at the air-liquid interface after e-cigarette aerosol exposure" [0.03%]
关于“电子烟气溶胶暴露后尼古丁驱动区域特异性人体呼吸道模型上清液-空气界面急性上皮损伤”的编辑来信回复
Ozge Kose,Clément Mercier,Jérémie Pourchez
Ozge Kose
Mitochondrial perspectives on environmental pollutant-induced male reproductive toxicity [0.03%]
环境污染物所致男性生殖毒性的线粒体学说视角
Qiujian Feng,Zhuozhi Gong,Bin Yan et al.
Qiujian Feng et al.
With rapid industrialization and urbanization, environmental pollutants have emerged as a major threat to male reproductive health, and declining semen quality and rising rates of male infertility have now become a global public health conc...
Comment on "Nicotine drives acute epithelial injury in region-specific human airway models at the air-liquid interface after e-cigarette aerosol exposure" [0.03%]
对“尼古丁驱动电子烟气溶胶暴露后特定区域人类呼吸道模型上清液-空气界面急性上皮损伤”的评论
Anuradha Mokkapati,Rhushvi Thakkar,Anjna Rani et al.
Anuradha Mokkapati et al.
Fluorene‑9‑bisphenol‑associated endoplasmic reticulum stress linked to oxidative stress, apoptosis and autophagy in SH‑SY5Y cells [0.03%]
新型阻燃剂9,9-双(4-羟基苯基)fluorene诱导神经细胞内质网应激及氧化损伤相关机制研究
Hongyan Wang,Yirong Hu,Xinxin Bi et al.
Hongyan Wang et al.
Fluorene-9-bisphenol (BHPF), an alternative to bisphenol A (BPA), is widely used to make polyester polymers and serves as an important organic intermediate in synthetic plastics. While diverse toxic effects of BHPF have been documented in t...