Long-chain chlorinated paraffins (LCCPs) exposure induces testicular aging damage by triggering mitochondrial dysfunction [0.03%]
长链氯化脂肪烃(LCCPs)暴露通过引发线粒体功能障碍诱导睾丸早衰损伤
Xue Tian,Yuebing Kong,Shuang Ma et al.
Xue Tian et al.
LCCPs is a widely recognized environmental pollutant, and its hazards to the environment and organisms have attracted significant attention. Toxicological research on LCCP's effects on the male reproductive system is limited, with mechanism...
Integrated cellular and molecular evidence of Amitraz-induced oxidative stress in SH-SY5Y spheroids [0.03%]
胺菊酯诱导的SH-SY5Y球形细胞类器官氧化应激的整合细胞及分子证据
F Franco-Campos,M Taroncher,Y Rodríguez-Carrasco et al.
F Franco-Campos et al.
Amitraz (AMZ), a formamidine acaricide widely used in apiculture, is frequently detected in honey at concentrations exceeding regulatory limits; however, its toxicological mechanisms in human systems remain poorly characterized. In this stu...
Targeting CX3CR1 inhibits silica-induced epithelial-mesenchymal transition and pulmonary fibrosis in mice via the NF-κB signaling pathway [0.03%]
针对CX3CR1通过NF-κB信号通路抑制小鼠二氧化硅诱导的上皮间质转化和肺纤维化
Jiaxin Zhang,Yuhua Wang,Chuanyi Huo et al.
Jiaxin Zhang et al.
Silicosis is the most severe occupational disease, with complex fibrotic mechanisms and a lack of effective therapies. Macrophage CX3CR1 has recently been found to play an important role in fibrosis diseases, and our previous studies have r...
Cadmium-induced hepatotoxicity: Interconnecting molecular and cellular pathways [0.03%]
镉诱导的肝毒性：分子和细胞途径的相互作用
Devaraj Ezhilarasan,Muthusethupathi Sharmila
Devaraj Ezhilarasan
Cadmium (Cd) is a persistent environmental toxicant with a prolonged biological half-life that accumulates in the liver following oral, intraperitoneal, or inhalational exposure. Experimental studies in murine models demonstrate that Cd-ind...
Nicotine alters alveolar-barrier integrity by blocking autophagy and occludin trafficking [0.03%]
尼古丁通过抑制自噬和闭合蛋白转运改变肺泡屏障的完整性
Amelia-Naomi Sabo,Emma Filaudeau,Anita Lebert et al.
Amelia-Naomi Sabo et al.
Tobacco smoke inhalation disrupts the integrity of the alveolar-capillary barrier (ACB) and contributes to the pathogenesis of multiple chronic pulmonary diseases as chronic obstructive pulmonary disease (COPD). Nicotine, a major component ...
Long-term exposure to N-(phosphonomethyl)glycine is associated with cancer stem cell-like properties in hormone-responsive breast cancer cells [0.03%]
长期暴露于草甘膦与激素反应性乳腺癌细胞的癌症干细胞样特性相关
Diego Soto-Jiménez,Diego Carrillo-Beltrán,Pablo Pérez-Moreno et al.
Diego Soto-Jiménez et al.
N-(phosphonomethyl)glycine, commonly known as glyphosate, is the most extensively used herbicide worldwide. Its widespread application in agriculture has led to continuous human exposure through food residues, contaminated water, and occupa...
CD44 expression in renal tubules during maladaptive repair is a potential marker for the transition from acute kidney injury to chronic kidney disease in rats [0.03%]
CD44在肾小管中的表达在不适应性修复过程中是啮齿动物从急性肾脏损伤转为慢性肾脏疾病的潜在标志物
Kohei Matsushita,Hirotoshi Akane,Jun-Ichi Akagi et al.
Kohei Matsushita et al.
Renal tubular epithelial cells (TECs) are major targets of drug-induced kidney injury, a cause of acute kidney injury (AKI). Although TEC regeneration aids recovery, maladaptive repair promotes fibrosis and chronic kidney disease (CKD). CD4...
Acute alcohol exposure induces reproductive behavior defects, subfertility, brain transcriptomic changes of parental zebrafish and malformation in their offspring [0.03%]
急性酒精暴露诱导双亲斑马鱼生殖行为缺陷、子代畸形及脑转录组变化
Li Peng,Jun-Yuan Lei,Yue-Ying Meng et al.
Li Peng et al.
Alcohol is a prevalent addictive substance and the consequences of alcohol abuse pose a significant public health concern. Despite its prevalence and pervasiveness in the modern world, the underlying mechanisms mediating alcohol's deleterio...
Ethylene glycol poisoning induces nephrolithiasis including complement-fibrinogen-related renal tubular injury in rats [0.03%]
乙二醇中毒可诱发大鼠肾结石形成及补体-纤维蛋白原相关的肾小管损伤
Kana Unuma,Shintaro Isa,Kanako Noritake et al.
Kana Unuma et al.
Renal tubular damage is one of the hallmarks of ethylene glycol (EG) poisoning and is associated with calcium oxalate crystals in the kidney. We firstly conducted transcriptome analysis to search novel mechanisms of renal toxicity during EG...
Mechanistic study on propoxate-induced neurotoxicity and addictive potential via blood-brain barrier disruption and GABAergic pathway activation [0.03%]
丙氧羧酸通过血脑屏障破坏和GABA能通路激活诱导神经毒性和成瘾潜能的机制研究
Renjuan Cao,Siming Ding,Jihong Cai et al.
Renjuan Cao et al.
In recent years, propoxate (PPO), a structural analogue of etomidate (ETO), has been illicitly added to e-cigarette liquids, while its neurotoxic and addictive mechanisms remain unclear. In this study, 8-week-old male C57BL/6 J mice were us...