Sub-chronic exposure to nanoplastics in vitro disrupts hepatic lipid homeostasis in human hepatocytes [0.03%]
亚慢性暴露于纳米塑料会干扰人肝细胞系中肝脏脂质稳态
Barbara Mognetti,Giuseppe Mannino,Alessia Brossa et al.
Barbara Mognetti et al.
Human exposure to micro- and nanoplastics is increasingly recognized as a global concern, yet their long-term effects on human health remain poorly understood. Defining the cellular consequences of chronic exposure is essential for reliable...
Bisphenol A induces osteoporosis by targeting LAMA4 and OLR1: Novel insights into environmental bone toxicity [0.03%]
双酚A通过靶向LAMA4和OLR1诱导骨质疏松症：环境因素导致骨骼毒性的新见解
Zhenyang Wang,Yongqin Chen,Jiling Ma et al.
Zhenyang Wang et al.
Background: Bisphenol A (BPA), a prevalent endocrine-disrupting chemical, is associated with osteoporosis (OP). However, the key molecular targets and mechanisms remain unclear. ...
Mechanistic Insights into Atrazine-Driven Endothelial Dysfunction: The Contribution of Endoplasmic Reticulum Stress [0.03%]
阿特拉津诱导内皮功能障碍的机制研究：内质网应激的作用
Chiara Indolfi,Melania Correale,Erika Esposito et al.
Chiara Indolfi et al.
Atrazine (ATZ) is one of the most used herbicides worldwide. To date, its impact on vascular function and the potential role as a risk factor for cardiometabolic diseases remain poorly investigated. Here, we demonstrated using mouse aorta r...
The impact of cannabigerol exposure on human endometrial stromal cells decidualization [0.03%]
大麻萜酚对人子宫内膜间充质细胞蜕膜化的影响
Patrícia Alves,Paul J Brighton,Chow Seng-Kong et al.
Patrícia Alves et al.
Decidualization denotes the inflammatory reprogramming of endometrial stromal cells (EnSC) into progesterone-dependent decidual cells (DC), a process essential for embryo implantation and placenta formation. Decidualization also gives rise ...
RUNX3 Mediates Aflatoxin B1-Induced Hepatocyte Apoptosis through Modulation of the Hippo Signaling Pathway [0.03%]
Hippo信号通路介导的_runx3_在黄曲霉素b1诱导的肝细胞凋亡中的作用
Yunying Mo,Yuanyuan Jiang,Shihan Huang et al.
Yunying Mo et al.
Aflatoxin B1 (AFB1) is a common foodborne mycotoxin that poses a serious threat to human and animal health, particularly through hepatotoxic effects. Although apoptosis is recognized as a central event in AFB1-induced liver injury, the upst...
Towards a novel toxicity prediction pipeline, combining PBPK models and mechanistic cellular adversity models [0.03%]
基于PBPK模型与机制型细胞毒性模型的新型毒理学预测体系的研究
Elsje J Burgers,Raju P Sharma,Tamara Y Danilyuk et al.
Elsje J Burgers et al.
There is a strong need for animal-free methods that properly predict drug adversity. Especially drug-induced liver injury (DILI) is a common adverse effect that is difficult to predict with current methodology. In this study, we developed a...
Transcriptomic and metabolomic analyses reveal cobalt-induced mitochondrial metabolic alterations in human cortical organoids [0.03%]
转录组和代谢组分析揭示了钴对人类皮层类器官线粒体代谢的重塑作用
Xinhua Guo,Hao Li,Yan Huang et al.
Xinhua Guo et al.
The global transition towards carbon-neutral energy systems has prompted a substantial increase in demand for cobalt (Co), making it a crucial component of lithium-ion batteries and advanced industrial materials. The widespread use and limi...
In vitro assessment of respiratory sensitization potential and allergic asthma: A miRNA-based approach [0.03%]
基于miRNA的方法体外评估呼吸敏化潜力和过敏性哮喘
Francesca Carlotta Passoni,Martina Iulini,Gloria Melzi et al.
Francesca Carlotta Passoni et al.
Occupational exposure to respiratory sensitizers is a major cause of allergic asthma. Although miRNAs are increasingly linked to asthma pathogenesis, their specific role in allergic asthma remains poorly defined. This study aims to assess a...
Comparative transcriptomics reveals shared stress and repair-associated pathway modules in proximal tubule cells exposed to platinum chemotherapeutics [0.03%]
比较转录组学揭示了暴露于铂类化疗药物的近端小管细胞中与压力和修复相关的途径模块的共享性
Devon A Barnes,Frank A Redegeld,Marcha Verheijen et al.
Devon A Barnes et al.
Platinum-based chemotherapeutics, including cisplatin, carboplatin, and oxaliplatin, are essential for treating solid malignancies but are limited by dose-dependent nephrotoxicity. The transcriptional programs shared across clinically used ...
Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice [0.03%]
人类抗原R缺陷雄性小鼠中异生素代谢失调和线粒体功能障碍加剧了乙酰氨基酚所致肝毒性
Natalie Eppler,Elizabeth Jones,Forkan Ahamed et al.
Natalie Eppler et al.
Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide. The RNA-binding protein Human antigen R (HuR) is a multifunctional post-transcriptional regulator that plays a pivotal role in cellular stress responses, inc...