Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard [0.03%]
关于组织禁止化学武器科学咨询委员会提供的援助和保护建议：第三部分。论芥子气所致损伤的医疗和治疗
Christopher M Timperley,Jonathan E Forman,Mohammad Abdollahi et al.
Christopher M Timperley et al.
Blister agents damage the skin, eyes, mucous membranes and subcutaneous tissues. Other toxic effects may occur after absorption. The response of the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons...
Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice [0.03%]
冯威利品牌因子对小鼠急性胆汁性肝损伤具有保护作用，但对慢性胆汁性肝损伤没有保护作用
Lauren G Poole,Anna-Katherine Fournier,Holly M Cline-Fedewa et al.
Lauren G Poole et al.
Acute and chronic liver disease are associated with substantial alterations in the hemostatic system, including elevated levels of the platelet-adhesive protein von Willebrand factor (VWF). Carbon tetrachloride-induced liver fibrosis is red...
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses [0.03%]
两种不同的毒素诱导的肾纤维化模型在炎症反应方面的比较研究
Yejin Yang,Sugyeong Ha,Somi Jeong et al.
Yejin Yang et al.
Chronic kidney disease (CKD) is characterized by persistent abnormalities in kidney function, accompanied by structural changes. Interstitial fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins, is frequently ...
Comparative Study
Toxicology. 2021 Nov:463:152973. DOI:10.1016/j.tox.2021.152973 2021
The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice [0.03%]
PD1抑制路径和成熟的树突状细胞对人白细胞抗原转基因PD1基因敲除小鼠中的阿巴卡韦超敏反应有所贡献
Binbin Song,Shigeki Aoki,Cong Liu et al.
Binbin Song et al.
Based on recent genome-wide association studies, abacavir-induced hypersensitivity is highly associated with human leukocyte antigen (HLA)-B*57:01 allele. However, the underlying mechanism of this occurrence is unclear. To investigate the u...
Bioaccessibility as a determining factor in the bioavailability and toxicokinetics of cadmium compounds [0.03%]
生物可利用性作为决定镉化合物的生物可用性和毒代动力学的因素
Craig A Poland,Noömi Lombaert,Carol Mackie et al.
Craig A Poland et al.
Cadmium toxicity occurs where there is absorption and accumulation of cadmium ions (Cd2+) in tissues beyond tolerable levels. Significant differences in the release of Cd2+ from cadmium compounds in biological fluids, like gastric fluid, ma...
Comparative Study
Toxicology. 2021 Nov:463:152969. DOI:10.1016/j.tox.2021.152969 2021
Effects of intrauterine exposure to concentrated ambient particles on allergic sensitization in juvenile mice [0.03%]
子宫内接触高浓度环境颗粒物对幼年小鼠过敏敏感性的影响
Jôse Mára de Brito,Francine Maria de Ameida,Fernanda Magalhães Arantes-Costa et al.
Jôse Mára de Brito et al.
Intrauterine exposure to particulate matter (PM) has been associated with an increased risk of asthma development, which may differ by the age of asthma onset, sex, and pollutant concentration. To investigate the pulmonary effects of in ute...
Endocrine disrupting chemicals: Friend or foe to brown and beige adipose tissue? [0.03%]
内分泌干扰物：对棕色和米色脂肪组织是敌是友？
Cynthia E Francis,Logan Allee,Helen Nguyen et al.
Cynthia E Francis et al.
The effects of Endocrine Disrupting Chemicals (EDCs) on the current obesity epidemic is a growing field of interest. Numerous EDCs have shown the potential to alter energy metabolism, which may increase the risk of obesity, in part, through...
Identifying the link between chemical exposures and breast cancer in African American women via integrated in vitro and exposure biomarker data [0.03%]
通过结合体外和暴露生物标志物数据识别化学物质暴露与非裔美国女性乳腺癌之间的联系
Katelyn M Polemi,Vy K Nguyen,Julien Heidt et al.
Katelyn M Polemi et al.
Among women, breast cancer is the most prevalent form of cancer worldwide and has the second highest mortality rate of any cancer in the United States. The breast cancer related death rate is 40 % higher in non-Hispanic Black women compared...
AHR/ROS-mediated mitochondria apoptosis contributes to benzo[a]pyrene-induced heart defects and the protective effects of resveratrol [0.03%]
AHR/ROS介导的线粒体凋亡导致苯并[α]芘引起的心脏缺陷以及白藜芦醇的保护作用
Yujie Huang,Jie Zhang,Yizhou Tao et al.
Yujie Huang et al.
Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon, is widely present in the environment. BaP-induced heart defects have been frequently reported, but the underlying molecular mechanisms remain elusive. Here, we found that...
Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity [0.03%]
自噬在层似胺诱导HeLa细胞线粒体应激反应中的作用研究
Pattarawut Sopha,Nadgrita Phutubtim,Bunkuea Chantrathonkul et al.
Pattarawut Sopha et al.
As a promising class of bioactive marine pyrrole alkaloids, lamellarins reportedly act on multiple targets to suppress the vitality of various cancer cell lines. Nevertheless, an in-depth understanding of the molecular mechanisms governing ...