Nicotine stimulates IL-8 expression via ROS/NF-κB and ROS/MAPK/AP-1 axis in human gastric cancer cells [0.03%]
尼古丁通过ROS/NF-κB和ROS/MAPK/AP-1轴诱导人胃癌细胞中IL-8的表达
Sen Lian,Shinan Li,Jun Zhu et al.
Sen Lian et al.
Nicotine, a major alkaloid found in tobacco, is a significant risk factor for gastric cancer. IL-8, a pleiotropic cytokine, plays a vital role in cancer cell metastasis. The role of nicotine in IL-8 expression and the underlying mechanism i...
Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths [0.03%]
不同直径和长度的亚微米级碳纤维的肺毒性、细胞毒性和遗传毒性
Katsuhide Fujita,Sawae Obara,Junko Maru
Katsuhide Fujita
Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. To accelerate their practical application, a hazard assessment of SCFs must be undertaken. This study demo...
Evaluation of lens opacity due to inhibition of cholesterol biosynthesis using rat lens explant cultures [0.03%]
胆固醇生物合成受抑导致晶状体浑浊的评价——大鼠晶状体组织培养的研究
Taishi Miyashita,Masanori Senshu,Kanata Ibi et al.
Taishi Miyashita et al.
Drug-induced lens opacity has the potential to cause blindness and is of concern in drug development. Inhibition of cholesterol biosynthesis is one of the causes of lens opacity. Lens opacity is only observed after chronic administration in...
Integrating in vitro chemical transplacental passage into a generic PBK model: A QIVIVE approach [0.03%]
将体外化学物质的胎盘转运整合到通用PBK模型中：一种QIVIVE方法
Styliani Fragki,Rudolf Hoogenveen,Conny van Oostrom et al.
Styliani Fragki et al.
With the increasing application of cell culture models as primary tools for predicting chemical safety, the quantitative extrapolation of the effective dose from in vitro to in vivo (QIVIVE) is of increasing importance. For developmental to...
Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation [0.03%]
铁死亡抑制剂减少了频繁过度饮酒引起的心房颤动的易感性
Chang Dai,Bin Kong,Tianyou Qin et al.
Chang Dai et al.
Both long-term and short-term alcohol consumption can cause internal homeostasis imbalance, and they have been proved to be related to the initiation and development of atrial fibrillation (AF). Ferroptosis is an iron-dependent form of non-...
Comparative Study
Toxicology. 2022 Jan 15:465:153055. DOI:10.1016/j.tox.2021.153055 2022
Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice [0.03%]
聚苯乙烯微塑料暴露对雄性和雌性小鼠生殖和生育能力影响的比较研究
Zhaolan Wei,Yunyi Wang,Shuwei Wang et al.
Zhaolan Wei et al.
Microplastics (MPs) may have an impact on the reproductive development of humans and mammals. However, any effects of MPs exposure on male and female reproductive systems and fertility are still ambiguous. In this study, male and female C57...
Comparative Study
Toxicology. 2022 Jan 15:465:153059. DOI:10.1016/j.tox.2021.153059 2022
Exposure to a combination of MWCNTs and DBP causes splenic toxicity in mice [0.03%]
MWCNTs和DBP的联合作用导致小鼠脾毒性
Tingting Zhou,Yueyan He,Yujie Qin et al.
Tingting Zhou et al.
The large conjugated π bond in the molecular structure of carbon nanotubes (CNTs) interacts with the benzene ring structure in di (n-butyl) phthalates (DBP) through a π - π bond. Compounds of CNTs and DBP form easily, becoming another en...
Microcystin-leucine arginine exposure induced intestinal lipid accumulation and MC-LR efflux disorder in Lithobates catesbeianus tadpoles [0.03%]
麦芽毒素-亮氨酸精氨酸暴露引起北方牛蛙蝌蚪肠道脂质堆积和MC-LR外排紊乱
Jun He,Yilin Shu,Yue Dai et al.
Jun He et al.
Few studies exist on the toxic effects of chronic exposure to microcystins (MCs) on amphibian intestines, and the toxicity mechanisms are unclear. Here, we evaluated the impact of subchronic exposure (30 days) to environmentally realistic m...
The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice [0.03%]
小鼠和人类过氧化物酶体增殖激活受体-α在调节全氟辛烷磺酸对小鼠肝脏影响中的作用
Shengzhong Su,Laura J Billy,Sue Chang et al.
Shengzhong Su et al.
Perfluorooctane sulfonate (PFOS) is a stable environmental contaminant that can activate peroxisome proliferator-activated receptor alpha (PPARα). In the present work, the specific role of mouse and human PPARα in mediating the hepatic ef...
PCB126 induced toxic actions on liver energy metabolism is mediated by AhR in rats [0.03%]
PCB126诱导的肝脏能量代谢毒性作用是大鼠AhR介导的
Nazmin Akter Eti,Susanne Flor,Khursheed Iqbal et al.
Nazmin Akter Eti et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the regulation of biological responses to more planar aromatic hydrocarbons, like TCDD. We previously described the sequence of events following expo...