Identification of estrogenic and DNA damaging chemicals using a combined morphological and genotoxic biomarker assay [0.03%]
Ann-Sophie Aßmann,Cynthia Recoules,Norman Ertych et al.
Ann-Sophie Aßmann et al.
One challenge for current chemical risk assessment is the integration of different in vitro based new approach methodologies (NAMs) to establish a concept for Next-Generation Risk Assessment (NGRA). It is particularly difficult to assess ac...
ALDH1A3-dependent ferroptosis mediates hexafluoropropylene oxide dimer acid-induced trophoblast dysfunction [0.03%]
Shanling Li,Hui Xu,Shuxian Li et al.
Shanling Li et al.
Hexafluoropropylene oxide dimer acid (HFPO-DA), a persistent per- and polyfluoroalkyl substance, has been epidemiologically associated with adverse pregnancy outcomes; however, the molecular mechanisms underlying its placental toxicity rema...
Time-resolved multi-omics reveals staged mitochondrial dysfunction and neurodegeneration-related changes in a tri-culture BTX neurotoxicity model [0.03%]
时间分辨的多组学揭示了BTX三文化神经毒性模型中分阶段的线粒体功能障碍和与神经退行性病变相关的改变
Siyu Wu,Airu Duan,Wanting Wang et al.
Siyu Wu et al.
Simultaneous benzene, toluene, and xylene (BTX) exposure is a common phenomenon in the workplace and the environment, but has not been well defined by time-resolved molecular events leading to BTX-induced neurotoxicity in multicellular sett...
Synergistic cytotoxicity of benzalkonium chloride and didecyldimethylammonium chloride mixtures revealed by stress granule formation [0.03%]
通过应力颗粒形成揭示苯扎氯铵和十二烷基二甲基溴化铵混合物的协同细胞毒性作用
Min-Jeong Kim,Eun-Mi Kim,Kee K Kim
Min-Jeong Kim
Benzalkonium chloride (BAC) and didecyldimethylammonium chloride (DDAC) are quaternary ammonium compound (QAC)-based biocides co-formulated into a wide range of commercial disinfectants, resulting in frequent, simultaneous exposure in human...
Deoxynivalenol induces the p21-mediated G₂/M arrest and upregulation of differentiation markers in human dental pulp stem cells [0.03%]
脱氧雪腐镰刀菌烯醇诱导人牙髓干细胞中p21介导的G2 / M停滞和分化标志物上调
Inji Shikhaliyeva,Gülruh Albayrak,Cenk Kığ et al.
Inji Shikhaliyeva et al.
Humans are constantly exposed to mycotoxins primarily through contaminated food. Deoxynivalenol (DON) is the most frequently occurring, and its toxicity to stem cells remains unclear. Mesenchymal stem cells (MSCs), responsible for tissue re...
Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish [0.03%]
胚胎期暴露于阿特拉津可干扰斑马鱼凯斯肽信号转导及下游神经内分泌调节机制
Sydney C Stradtman,Umamaheswari Sathisaran,Benjamin K Dierolf et al.
Sydney C Stradtman et al.
Atrazine is an herbicide used to control broadleaf and grassy weeds but is also a known endocrine disrupting chemical classified by the US EPA for its effect on the luteinizing hormone (LH) surge. The US EPA's maximum contaminant level (MCL...
Circadian PER2 Promotes T-2 Toxin-induced Immunosenescence by Activating the Hippo/MST1 Signaling in Macrophages [0.03%]
CLOCK PER2通过激活巨噬细胞中的昼夜节律Hippo/MST1信号促进T-2毒素诱导的免疫衰老
Junyao Li,Xueqin Huang,Wei Wei et al.
Junyao Li et al.
T-2 toxin induces severe cytotoxicity and immunosenescence, but the underlying mechanisms, particularly the role of circadian rhythm disruption, still lack a clear understanding. This study explores the function of the circadian PER2 and th...
MEHP exposure disrupts the self-renewal and differentiation of GC-1 cells by up-regulating m6A levels, leading to reproductive damage in immature rats [0.03%]
MEHP暴露通过上调m6A水平干扰GC-1细胞的自我更新和分化从而导致未成年雄性大鼠生殖损害
Yanjun Ding,Xiazhu Zhou,Yifan Hong et al.
Yanjun Ding et al.
Di-(2-ethylhexyl) phthalate (DEHP) and its active metabolite mono-(2-ethylhexyl) phthalate (MEHP) are environmental endocrine disruptors associated with male reproductive toxicity, but the underlying mechanisms remain unclear. This study in...
Sustained activation of M1 microglia by oligomerized alpha-synuclein released from dopaminergic neuronal damage through CD11b/Src/Erk/NOX2 axis after Paraquat exposure [0.03%]
暴露于百草枯后，通过CD11b/Src/Erk/NOX2轴释放的多巴胺能神经元损伤源的寡聚α-突触核蛋白持续激活M1小胶质细胞
Qian Cai,Qianqian Jing,Ge Shi et al.
Qian Cai et al.
Environmental factors, particularly exposure to herbicides and insecticides, are closely associated with neuroinflammation and the progression of Parkinson's disease (PD). Paraquat (PQ) is a widely used herbicide that has been reported to d...
Applicability of the U-SENS™ Assay for Assessing Skin Sensitization Potential of Agrochemical Active Ingredients and Formulations [0.03%]
U-SENS™ 试验在农药原药及制剂皮肤致敏潜在性评估中的适用性
Mariela Lenze,Martina Daniela Benedetti,Mora Renée García et al.
Mariela Lenze et al.
Skin sensitization testing is essential for the regulatory classification of agrochemicals, including active ingredients (AIs) and formulations. Although several alternative methods have been developed, their application to agrochemicals re...