Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening [0.03%]
缺氧/复氧通过开放线粒体过渡态孔道加重药物所致细胞毒性：其作为毒力筛查应用的可能性
Yugo Ikeyama,Tomoyuki Sato,Akinori Takemura et al.
Yugo Ikeyama et al.
Recently, mitochondrial dysfunction is thought of as an important factor leading to a drug-induced liver injury. Our previous reports show that mitochondria-related toxicity, including respiratory chain inhibition (RCI) and reactive oxygen ...
DCMQA, a caffeoylquinic acid derivative alleviates NMDA-induced neurotoxicity via modulating GluN2A and GluN2B-containing NMDA receptors in vitro [0.03%]
_DCQMFA通过调节GluN2A和GluN2B含有的N-甲基-D天冬氨酸受体缓解体内NMDA诱导的神经毒性
Yue Yang,Huan Gao,Wenwu Liu et al.
Yue Yang et al.
Compound DCMQA (4, 5-O-dicaffeoyl-1-O-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. Caffeoylquinic acid derivatives have been reported to possess neuroprotective e...
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells [0.03%]
西妥昔单抗通过线粒体途径和内质网应激增强ords在喉癌鳞状细胞系中的诱导凋亡作用
Ning Kang,Shijie Cao,Benke Jiang et al.
Ning Kang et al.
Cetuximab plus oridonin showed a synergistic way to kill laryngeal squamous cell carcinoma (LSCC), as been reported previously. The present work further mechanistically extended action of the synergistic effects of combination treatment. Fi...
Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway [0.03%]
苯并苯酮-3和苯并苯酮-8通过过氧化物酶体增殖激活受体γ通路表现出致肥胖作用
Jeayoung C Shin,Eunyoung Lee,Seungchan An et al.
Jeayoung C Shin et al.
Benzophenone-3 (BP-3) and benzopenone-8 (BP-8) are commonly used ultraviolet (UV) filter ingredients in diverse sunscreen products. Recently, the obesogenic activity of avobenzone, a long wave UV A filter, was elucidated in the adipogenesis...
Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract [0.03%]
抗氧化剂对暴露于颗粒物和烟草烟雾提取物的人支气管上皮细胞的氧化应激和炎症反应的影响
Eun Suk Son,Jeong-Woong Park,Yu Jin Kim et al.
Eun Suk Son et al.
Particulate matter (PM) is a type of air pollutant that induces adverse health effects, including acute exacerbation of chronic obstructive pulmonary disease (COPD). However, the effects of co-exposure to PM and cigarette smoke extract (CSE...
Ignacio J Tripodi,Tiffany J Callahan,Jessica T Westfall et al.
Ignacio J Tripodi et al.
When considering toxic chemicals in the environment, a mechanistic, causal explanation of toxicity may be preferred over a statistical or machine learning-based prediction by itself. Elucidating a mechanism of toxicity is, however, a costly...
Comparative γ-H2AX analysis for assessment of the genotoxicity of six aromatic amines implicated in bladder cancer in human urothelial cell line [0.03%]
六种芳香胺致膀胱癌的遗传毒性评估的γ-H2AX比较分析：人类尿路上皮细胞系模型研究
Yonggang Qi,Tatsushi Toyooka,Jisheng Nie et al.
Yonggang Qi et al.
Recently, it was reported that ten cases of bladder cancer occurred among employees, who handled several kinds of aromatic amines, at a Japanese chemical plant. The common aromatic amines were identified as ortho-toluidine, para-toluidine, ...
Bisphenol A triggers the malignancy of nasopharyngeal carcinoma cells via activation of Wnt/β-catenin pathway [0.03%]
双酚A通过激活Wnt/β-连环蛋白信号通路诱发鼻咽癌细胞恶性转化
Wenhui Zeng
Wenhui Zeng
It is critical to understand the risk factors responsible for the tumorigenesis and progression of nasopharyngeal carcinoma (NPC). Bisphenol A (BPA) can regulate the estrogenic signals to modulate cancer progression, while its roles in NC w...
22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells [0.03%]
22β-羟基TINGA酮通过抑制Akt/mTOR信号传导途径减少人黑色素瘤细胞增殖和侵袭
Elenn Suzany Pereira Aranha,Emerson Lucena da Silva,Felipe Pantoja Mesquita et al.
Elenn Suzany Pereira Aranha et al.
Melanoma is a skin cancer with high invasive potential and high lethality. Considering that quinonemethide triterpenes are described as promising anticancer agents, the aim of this study was to evaluate the effect of 22β-hydroxytingenone (...
Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs? [0.03%]
人工内分泌干扰物的风险评估问题及其与天然雌激素的比较研究
Herman Autrup,Frank A Barile,Sir Colin Berry et al.
Herman Autrup et al.
Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to en...