In vitro effects of dental monomer exposure - Dependence on the cell culture model [0.03%]
牙科单体暴露的体外效应-取决于细胞培养模型
Else Morisbak,Solveig Uvsløkk,Jan T Samuelsen
Else Morisbak
Methacrylate monomers are major components of resin-based biomaterials. The polymerization of these materials is never complete, and methacrylates leaking from cured materials cause exposure of patients. Only some selected methacrylates hav...
P53 activation suppresses irinotecan metabolite SN-38-induced cell damage in non-malignant but not malignant epithelial colonic cells [0.03%]
p53激活抑制非恶性但不能抑制恶性结肠上皮细胞中irinotecan代谢产物SN-38诱导的细胞损伤
Bavani Gunasegaran,Paul M Neilsen,Scott D Smid
Bavani Gunasegaran
Nutlin-3a is a p53 activator and potential cyclotherapy approach that may also mitigate side effects of chemotherapeutic drugs in the treatment of colorectal cancer. We investigated cell proliferation in a panel of colorectal cancer (CRC) c...
Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5 [0.03%]
人外周血淋巴细胞瘤MCL-5细胞系中佛波酯诱导的增殖反应及其对苯并[a]芘代谢活化产物的敏感性研究
Fiona M Chapman,Chris Sparham,Colin Hastie et al.
Fiona M Chapman et al.
Genotoxicity testing methods in vitro provide a means to predict the DNA damaging effects of chemicals on human cells. This is hindered in the case of hydrophobic test compounds, however, which will partition to in vitro components such as ...
The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium [0.03%]
合成无定形二氧化硅（E 551）对分化Caco-2细胞的影响，一种人类肠上皮模型
Claudia Hempt,Jean-Pierre Kaiser,Olivier Scholder et al.
Claudia Hempt et al.
For several decades, food-grade synthetic amorphous silica (SAS) have been used as a technological additive to reduce caking of food powders. Human exposure is thus inevitable and safety concerns are taken seriously. The toxicity of silica ...
Identifying adipogenic chemicals: Disparate effects in 3T3-L1, OP9 and primary mesenchymal multipotent cell models [0.03%]
鉴别促脂肪生成的化学物质：3T3-L1、OP9和原代间充质多能细胞模型中的不同作用
Faye V Andrews,Stephanie M Kim,Lariah Edwards et al.
Faye V Andrews et al.
3T3-L1 pre-adipocytes are used commonly to identify new adipogens, but this cell line has been shown to produce variable results. Here, potential adipogenic chemicals (identified in the ToxCast dataset using the Toxicological Priority Index...
Piceatannol exhibits potential food-drug interactions through the inhibition of human UDP-glucuronosyltransferase (UGT) in Vitro [0.03%]
白杨素通过抑制人UDP葡萄糖醛酸转移酶(UGT)的活性而表现出潜在的食品-药物相互作用
Lili Jiang,Zhen Wang,Xiaoyu Wang et al.
Lili Jiang et al.
Piceatannol is a natural polyphenol compound found in passion fruit and blueberry with several biological activities. However, it is unclear whether piceatannol affects the activity of human UDP-glucuronosyltransferases (UGTs) enzymes. The ...
Evaluation of in vitro models of stem cell-derived cardiomyocytes to screen for potential cardiotoxicity of chemicals [0.03%]
评估体外模型中由干细胞衍生的心肌细胞筛选化学品的潜在心毒性
Miaoying Shi,Nguyen T Tien,Laura de Haan et al.
Miaoying Shi et al.
Cardiotoxicity is an important toxicological endpoint for chemical and drug safety assessment. The present study aims to evaluate two stemcell-based in vitro models for cardiotoxicity screening of chemicals. Eleven model compounds were used...
The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study [0.03%]
MITF和Mcl-1蛋白在环丙沙星对无色素黑色素瘤细胞抗增殖和促凋亡作用中的角色：基于计算和体外研究
Artur Beberok,Jakub Rok,Zuzanna Rzepka et al.
Artur Beberok et al.
Mcl-1 is a potent antiapoptotic protein which is amplified in many human cancer, while microphthalmia associated transcription factor (MITF) promotes cell proliferation and has pro-survival role. The study was designed to examine whether th...
Effects of nicotine on porcine pre-pupertal sertoli cells: An in vitro study [0.03%]
尼古丁对猪前期spermatogcell体外研究的影响
Lorella Marinucci,Stefania Balloni,Catia Bellucci et al.
Lorella Marinucci et al.
Smoke components, such as nicotine and its major metabolites, cross the blood-testis barrier and are detectable in the seminal plasma of both active smokers and individuals exposed to cigarette smoke. In vivo studies in a rat model have fur...
Assessment of intestinal absorption/metabolism of 3-chloro-1,2-propanediol (3-MCPD) and three 3-MCPD monoesters by Caco-2 cells [0.03%]
Caco-2细胞对3-氯-1,2-丙二醇(3-MCPD)及三种3-MCPD单酯吸收/代谢的评价研究
Magali Araujo,Jessica K Beekman,Mapa S T Mapa et al.
Magali Araujo et al.
3-chloro-1,2-propanediol (3-MCPD) and 3-MCPD esters are contaminants present in a variety of processed foods, including infant formulas. Toxicological data are unavailable in humans, but rodent studies have demonstrated renal and testicular...