Cryopreservation affected the levels of immune responses of PBMCs and antigen-presenting cells [0.03%]
冻存对PBMC和抗原递呈细胞水平的免疫反应的影响
Maria-Viola Martikainen,Marjut Roponen
Maria-Viola Martikainen
The effect of cryopreservation on antigen-presenting cells (APCs) is understudied. It is important to understand the effects of cryopreservation on these cells as they play a major role in immune responses, and they could be utilized in dif...
An integrated chemical environment with tools for chemical safety testing [0.03%]
用于化学安全测试的集成化学环境及工具
Shannon Bell,Jaleh Abedini,Patricia Ceger et al.
Shannon Bell et al.
Moving toward species-relevant chemical safety assessments and away from animal testing requires access to reliable data to develop and build confidence in new approaches. The Integrated Chemical Environment (ICE) provides tools and curated...
Skin penetration and decontamination efficacy following human skin exposure to fentanyl [0.03%]
人体皮肤接触芬太尼后的透皮吸收及去污效能研究
Lina Thors,Linda Öberg,Emma Forsberg et al.
Lina Thors et al.
Unintentional exposure to potent synthetic opioids during law enforcement seizures and rescue operations can potentially result in incapacitating effects or life-threatening respiratory depression. The hazard comes mainly from inhalation ex...
Styrene alters potassium endolymphatic concentration in a model of cultured utricle explants [0.03%]
styrene改变钾内淋巴浓度的耳石培养模型
V Tallandier,L Merlen,S Boucard et al.
V Tallandier et al.
Despite well-documented neurotoxic and ototoxic properties, styrene remains commonly used in industry. Its effects on the cochlea have been extensively studied in animals, and epidemiological and animal evidence indicates an impact on balan...
Suppressing growth, migration, and invasion of human hepatocellular carcinoma HepG2 cells by Catharanthus roseus‑silver nanoparticles [0.03%]
夹竹桃银纳米颗粒通过抑制肝癌细胞HepG2的生长、迁移和侵袭起作用
Nur Asna Azhar,Siti Zulaikha Ghozali,Siti Aishah Abu Bakar et al.
Nur Asna Azhar et al.
Application of silver nanoparticles serves as a new approach in cancer treatment due to its unique features. Biosynthesis of silver nanoparticles using plant is advantageous since they are easily accessible, nontoxic and produce quicker rea...
Incorporating ToxCast™ data into naphthalene human health risk assessment [0.03%]
毒性铸造数据在萘人体健康风险评估中的应用
Lisa A Bailey,Lorenz R Rhomberg
Lisa A Bailey
Chronic inhalation of naphthalene causes nasal olfactory epithelial tumors in rats and benign lung adenomas in mice. The available human data do not establish an association between naphthalene and increased respiratory cancer risk. Therefo...
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells [0.03%]
双酚A致神经毒性及其对神经细胞突触和细胞骨架的影响
Zhihong Yin,Liushuai Hua,Lingli Chen et al.
Zhihong Yin et al.
Bisphenol A (BPA) is an environmental chemical that induces neurotoxic effects for human. Synaptophysin (SYP) and drebrin (Dbn) proteins are involved in regulating synaptic morphology. The stability of the cytoskeleton in nerve cells in the...
Cadmium exposure activates Akt/ERK Signaling and pro-inflammatory COX-2 expression in human gallbladder epithelial cells via a ROS dependent mechanism [0.03%]
镉通过依赖ROS的作用机制激活人胆囊上皮细胞中的Akt / ERK信号和促炎COX-2表达
Priyanka Sharma,Trevar S Caldwell,Megan N Rivera et al.
Priyanka Sharma et al.
Gallbladder cancer (GBC) is the commonest biliary tract cancer with an ill-defined etiology. We examined the role of Cd+2 exposures in a primary human gallbladder (GB) cell line model in this study. Cd+2 exposures induced decreased cell via...
Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES) [0.03%]
新一代气溶胶暴露系统的研发与测试：独立整体式气液暴露系统(InHALES)
Sandro Steiner,Pierre Herve,Claudius Pak et al.
Sandro Steiner et al.
The dose of inhaled materials delivered to the respiratory tract is to a large extent a function of the kinetics of particle deposition and gas dissolution on or in the airway and lung epithelia, and therefore of the structural and function...
Abby Hearne,Haotong Chen,Anna Monarchino et al.
Abby Hearne et al.
Oligomycin is a classical mitochondrial reagent that binds to the proton channel on the Fo component of ATP synthase. As a result, oligomycin blocks mitochondrial ATP synthesis, proton translocation, and O2 uptake. Here we show that oligomy...