Human keratinocytes and monocytes co-culture cell system: An important contribution for the study of moderate and weak sensitizers [0.03%]
人角质形成细胞和单核细胞共培养系统在中弱敏原研究中的应用及意义
Valentina Galbiati,Ambra Maddalon,Martina Iulini et al.
Valentina Galbiati et al.
In vitro approaches to address key events in chemical-induced skin sensitization have been developed, but there is still uncertain how they will be useful to predict the potency for an effective risk assessment. Keratinocytes (KCs) play a k...
Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs [0.03%]
人体回肠类器官模型再现小分子药物相关腹泻的临床发生率
David G Belair,Richard J Visconti,Miyoun Hong et al.
David G Belair et al.
Drug-induced gastrointestinal toxicity (GIT) is a common treatment-emergent adverse event that can negatively impact dosing, thereby limiting efficacy and treatment options for patients. An in vitro assay of GIT is needed to address patient...
In vitro administration of sodium arsenite in mouse prepubertal testis induces germ cell loss and apoptosis [0.03%]
亚砷酸钠在小鼠青春期前睾丸中的体外给药会引起生精细胞丢失和凋亡
Naureen Anwar,Irfan Zia Qureshi,Norah Spears et al.
Naureen Anwar et al.
High levels of arsenic contamination in drinking water pose serious health risks in numerous countries. The documentation reporting arsenic toxicity on reproduction and development is increasing, with evidence of arsenic inducing fertility ...
Role of calcium-sensing receptor in cadmium-induced apoptosis of rat primary osteoblasts in vitro [0.03%]
钙离子感受器在镉致大鼠原代成骨细胞凋亡中的作用机制研究
Di Ran,Wei Liu,Yonggang Ma et al.
Di Ran et al.
Calcium is essential to various physiological and pathophysiological cellular processes. Calcium-sensing receptor (CasR), a seven-transmembrane-spanning protein that responds to changes in extracellular Ca2+, partly modulates calcium homeos...
Chronic and acute arsenic exposure enhance EGFR expression via distinct molecular mechanisms [0.03%]
慢性及急性砷暴露通过不同的分子机制增强EGFR的表达
Christine Kim,J Christopher States,Brian P Ceresa
Christine Kim
The impacts of acute arsenic exposure (i.e. vomiting, diarrhea, and renal failure) are distinct from those brought about by sustained, low level exposure from environmental sources or drinking of contaminated well water. Chronic arsenic exp...
Trastuzumab-induced cardiotoxicity and role of mitochondrial connexin43 in the adaptive response [0.03%]
曲妥珠单抗致心肌毒性和线粒体连接蛋白43在适应性反应中的作用
Michela Pecoraro,Aldo Pinto,Ada Popolo
Michela Pecoraro
Trastuzumab, the humanized monoclonal antibody specific for HER2 receptor, is the gold standard in the treatment of HER2+ breast cancer. Despite its high therapeutic efficacy, cardiotoxicity has emerged as a significant side effect. The mol...
Assessment of α-amanitin toxicity and effects of silibinin and penicillin in different in vitro models [0.03%]
α-鹅膏蕈碱毒性评价及异硫氰酸盐和青霉素在不同体外模型中作用的影响评估
Tanja Popp,Frank Balszuweit,Annette Schmidt et al.
Tanja Popp et al.
Silibinin (Sil) is used as hepatoprotective drug and is approved for therapeutic use in amanitin poisoning. In our study we compared Sil-bis-succinate (SilBS), a water-soluble drug approved for i.v.-administration, with Sil solved in ethano...
Host microbiota dictates the proinflammatory impact of LPS in the murine liver [0.03%]
宿主微生物群决定LPS在小鼠肝脏中的促炎作用
Su Suriguga,Theerut Luangmonkong,Henricus A M Mutsaers et al.
Su Suriguga et al.
Gut microbiota can impact liver disease development via the gut-liver axis. Liver inflammation is a shared pathological event in various liver diseases and gut microbiota might influence this pathological process. In this study, we studied ...
Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment [0.03%]
基于铜转运蛋白1亲和力的合理设计铜(ii)配合物输送策略以改善其细胞毒性作用及应用于癌症治疗的效果研究
Ramon Handerson Gomes Teles,Angelica Ellen Graminha,Cosette M Rivera-Cruz et al.
Ramon Handerson Gomes Teles et al.
Cisplatin is widely used to treat different types of cancer, but its severe side effects are the major disadvantage of this treatment. Therefore, other metals are currently the subject of research in the rational development of anticancer d...
Nanolipid-loaded Preyssler polyoxometalate: Synthesis, characterization and invitro inhibitory effects on HepG2 tumor cells [0.03%]
纳米脂质载Preyssler多金属氧体的合成、表征及体外抑制HepG2肿瘤细胞效应研究
Safieh Fazel Razavi,Fatemeh F Bamoharram,Toktam Hashemi et al.
Safieh Fazel Razavi et al.
Polyoxometalate-based drugs have been selected by some researchers as alternative antitumor substances with promising results in suppression of tumor growth because of low toxicity towards the human body and high activity. In this research,...