Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10 [0.03%]
棕榈酸诱导的心肌细胞毒性与线粒体呼吸功能障碍及氧化应激加速有关：辅酶Q9/10的关键作用
Phiwayinkosi V Dludla,Sonia Silvestri,Patrick Orlando et al.
Phiwayinkosi V Dludla et al.
Impaired mitochondrial function concomitant to enhanced oxidative stress-induced damage are well established mechanisms involved in hyperlipidemia-induced cardiotoxicity. Currently, limited information is available on the direct effect of m...
Etomidate is devoid of genotoxicty and mutagenicity in human lymphocytes and in the Salmonella typhimurium/microsomal activation test [0.03%]
依托咪酯未显示出致遗传毒性及致突变性（人淋巴细胞及鼠伤寒杆菌微粒体活化试验）
Bruno Coêlho Cavalcanti,Lívia Gurgel do Amaral Valente Sá,João Batista de Andrade Neto et al.
Bruno Coêlho Cavalcanti et al.
No carcinogenesis or mutagenesis studies have been carried out with etomidate. The current study showed that etomidate has weak cytotoxic potential after 48 h exposure in human lymphocytes and has no hemolytic activity. The weak cytotoxicit...
In vitro Notch-mediated adjuvant immunogenic potency is induced by combining QS-21 and MPL in a co-culture model of PBMC and HUVEC cells [0.03%]
QS-21和MPL联合诱导促炎免疫原性的体外 notch 介导的佐剂效力模型研究
C Campos-Estrada,B Riquelme,M Vergara et al.
C Campos-Estrada et al.
Few vaccine adjuvants have been approved for human use although several are currently being studied in preclinical and clinical trial. MPL is a toll-like receptor agonist able to trigger a high and persistent antibody response via-TLR-4 whi...
New insights for screening etomidate analogues in the human H295R cell model [0.03%]
人H295R细胞模型中乙托菲诺类似物筛查的新见解
Chaoyi Deng,Deying Gong,Jun Yang et al.
Chaoyi Deng et al.
Etomidate is a sedative-hypnotic with excellent pharmacological effects, including rapid onset and hemodynamic stability. However, etomidate causes adrenocortical toxicity via binding to 11β-hydroxylase. Therefore, developing an approach t...
Trans, trans-2,4-decadienal (tt-DDE), a composition of cooking oil fumes, induces oxidative stress and endoplasmic reticulum stress in human corneal epithelial cells [0.03%]
烹饪油烟成分反式反式-2,4-癸二烯醛（tt-DDE）诱导人角膜上皮细胞氧化应激和内质网应激
Chenxi Yan,Lifang Zhang,Bing Lu et al.
Chenxi Yan et al.
Indoor pollution with cooking oil fumes (COF) as one of the main components is closely related to ocular surface disorders. However, as the most abundant aldehyde in COF, the toxicity of trans, trans-2,4-decadienal (tt-DDE) on human cornea ...
Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry [0.03%]
高效液相色谱-质谱联用技术体外鉴定UV-327的I相代谢产物
Corinna Fischer,Edgar Leibold,Thomas Göen
Corinna Fischer
The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is used in various plastic products to protect them against harmful UV radiation. Meanwhile, there are concerns about potential adverse...
An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole [0.03%]
弗苯达唑诱导黑素瘤细胞有丝分裂灾难及下游细胞反应的分析研究
K Rudolf,E Rudolf
K Rudolf
Mitotic catastrophe induced by mictotubule-targeting drugs such as benzimidazole carbamates has been demonstrated to be an efficient mechanism for suppression of tumor cells growth and proliferation, with variable resulting endpoints. The p...
Novel cytokine marker available for skin irritation testing of medical devices using reconstructed human epidermis models [0.03%]
用于医疗设备皮肤刺激测试的重建人表皮模型的新细胞因子标志物可用
Reiko Kato,Atsuko Miyajima,Kaoru Komoriya et al.
Reiko Kato et al.
In biological safety evaluation of medical devices, false-negative results have been observed during skin irritation testing using the reconstructed human epidermis (RhE) model when measuring cell viability as a single marker. Therefore, to...
Comparative analysis of biological effects of molybdenum(IV) sulfide in the form of nano- and microparticles on human hepatoma HepG2 cells grown in 2D and 3D models [0.03%]
二维和三维培养的肝癌HepG2细胞中纳米和微米硫化钼（Ⅳ）生物效应的比较研究分析
Z Sobańska,K Domeradzka-Gajda,M Szparaga et al.
Z Sobańska et al.
Significance of MoS2 nanoparticles as a lubricant or drug carriers indicates the need to assess their safety. In the study we analyzed the effects of MoS2 nano- and microparticles and their internalization in vitro, using 2D and 3D culture ...
A tetraprenylated benzophenone 7-epiclusianone induces cell cycle arrest at G1/S transition by modulating critical regulators of cell cycle in breast cancer cell lines [0.03%]
四牻牛儿基化苯骈菲酮7-epiclusianone通过调节细胞周期的关键调控因子使乳腺癌细胞系在G1/S期停止生长
Simone da Silva Lamartine-Hanemann,Guilherme Álvaro Ferreira-Silva,Renato de Oliveira Horvath et al.
Simone da Silva Lamartine-Hanemann et al.
Breast cancer is a complex disease and encompassing different types of tumor. Although advances in understanding of the molecular bases of breast cancer biology, the therapeutic proposals available still are not effective. In this scenario,...