A novel assessment system of toxicity and stability of CuO nanoparticles via copper super sensitive Saccharomyces cerevisiae mutants [0.03%]
铜超敏感的酵母突变株对铜纳米粒子毒性和稳定性的一种新的评价系统
Xueqing Chen,Ruixia Zhang,Jing Sun et al.
Xueqing Chen et al.
CuO nanoparticles (CuO-NPs) toxicity in organisms is contributed mainly through the copper uptake by both the ionic and nanoparticle form. However, the relative uptake ratio and bioavailability of the two different forms is not well known d...
YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells [0.03%]
YAN是一种新型的微管抑制剂，可抑制P-gp和MRP1功能，并在多药耐药A549 / Taxol细胞中诱导有丝分裂滑移进而凋亡
Minghuan Gao,Tong Liu,Jingnan Li et al.
Minghuan Gao et al.
Lung cancer is the most common cause of cancer-related death worldwide. The occurrence of multidrug resistance (MDR) affects the therapeutic efficacy of chemotherapeutics. Therefore, to develop new anticarcinogen which can overcome MDR is u...
2'-Hydroxyflavanone prevents LPS-induced inflammatory response and cytotoxicity in murine macrophages [0.03%]
2'-羟基黄酮可预防LPS诱导的小鼠巨噬细胞炎症反应和细胞毒性
Himangshu Sonowal,Kota V Ramana
Himangshu Sonowal
2'-Hydroxyflavanone (2-HF) is a natural flavonoid isolated from citrus fruits. Multiple studies have demonstrated that 2-HF with its anti-proliferative and pro-apoptotic effects prevent the growth of various cancers. Although 2-HF is a well...
Toxic effects of the anticancer drug epirubicin in vitro assayed in human erythrocytes [0.03%]
抗肿瘤药物表阿霉素的毒性效应以人体红细胞为模型的体外检测研究
Karla Petit,Mario Suwalsky,José R Colina et al.
Karla Petit et al.
Epirubicin is a cytotoxic drug used in the treatment of different types of cancer and increasing evidence suggests that its target is cell membranes. In order to gain insight on its toxic effects, intact red blood cells (RBC), human erythro...
Chelerythrine hydrochloride inhibits proliferation and induces mitochondrial apoptosis in cervical cancer cells via PI3K/BAD signaling pathway [0.03%]
氯化仙苔醛甲胺通过PI3K/BAD信号通路抑制宫颈癌细胞增殖并诱导线粒体凋亡
Tianfeng Yang,Rui Xu,Qi Su et al.
Tianfeng Yang et al.
Cervical cancer is the fourth most common female cancer worldwide, and drug targeted therapy plays a crucial role in delaying the progression of cervical carcinoma. Chelerythrine hydrochloride (CHE) is a natural alkaloid, which is a focal p...
Employment of cytology for in vitro skin irritation test using a reconstructed human epidermis model, Keraskin™ [0.03%]
使用重组人表皮模型Keraskin™进行皮肤刺激体外试验中的细胞学应用
Jee-Hyun Hwang,Haengdueng Jeong,Sumin Hur et al.
Jee-Hyun Hwang et al.
Skin irritation tests using reconstructed human epidermis (RhE) employ viability as an endpoint, but color interference or borderline results are often problematic. We examined whether the cytology of cells from treated RhE could determine ...
Effects of pulse-modulated radiofrequency magnetic field (RF-EMF) exposure on apoptosis, autophagy, oxidative stress and electron chain transport function in human neuroblastoma and murine microglial cells [0.03%]
脉冲调制射频电磁场(RF-EMF)暴露对人神经母细胞瘤和鼠小胶质细胞凋亡、自噬、氧化应激及电子链转运功能的影响
Jana Zielinski,Angélique D Ducray,Anja M Moeller et al.
Jana Zielinski et al.
The use of body-worn wireless devices with different communication protocols and rapidly changing exposure scenarios is still multiplying and the need to identify possible health effects of radiofrequency electromagnetic field (RF-EMF) expo...
Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro [0.03%]
rutin负载液晶纳米颗粒抑制脂多糖诱导的气管上皮细胞氧化应激和凋亡率villa
Keshav Raj Paudel,Ridhima Wadhwa,Meenu Mehta et al.
Keshav Raj Paudel et al.
Airway inflammation and infections are the primary causes of damage in the airway epithelium, that lead to hypersecretion of mucus and airway hyper-responsiveness. The role of reactive oxygen species (ROS) and their components in the pathop...
Development of the SkinEthic HCE Time-to-Toxicity test method for identifying liquid chemicals not requiring classification and labelling and liquids inducing serious eye damage and eye irritation [0.03%]
用于识别无需分类和标签的液体化学品以及引起严重眼损伤和眼刺激液体的SkinEthic HCE 时间毒性测试方法的开发
Nathalie Alépée,Virginie Leblanc,Marie-Hélène Grandidier et al.
Nathalie Alépée et al.
This study describes the development of a Time-to-Toxicity approach for liquids (TTL) based on the SkinEthic™ HCE tissue construct, capable to distinguish chemicals that do not require classification for serious eye damage/eye irritation (...
In vitro evaluation of the hepatic lipid accumulation of bisphenol analogs: A high-content screening assay [0.03%]
双酚类似物的体外肝脂质积累评价：高内涵筛选分析
Qian Liu,Wentao Shao,Zhenkun Weng et al.
Qian Liu et al.
Bisphenol A (BPA) has a variety of adverse effects on human health; therefore, BPA analogs are increasingly used as replacements. Notably, recent studies have revealed that BPA exposure induced hepatic lipid accumulation, but few studies ar...