Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids [0.03%]
人完整皮肤、分离皮肤层和分离角质层脂质中50种化合物的分配系数和扩散系数测定
Corie A Ellison,Kevin O Tankersley,Cindy M Obringer et al.
Corie A Ellison et al.
A standard protocol was used to determine partition (K) and diffusion (D) coefficients in dermatomed human skin and isolated human skin layers for 50 compounds relevant to cosmetics ingredients. K values were measured in dermatomed skin, is...
Perfluorooctane sulfonate induced toxicity in embryonic stem cell-derived cardiomyocytes via inhibiting autophagy-lysosome pathway [0.03%]
全氟辛烷磺酸通过抑制自噬溶酶体途径诱导胚胎干细胞来源的心肌细胞毒性
Dan Liu,Nuo-Ya Liu,Li-Ting Chen et al.
Dan Liu et al.
Perfluorooctane sulfonate (PFOS), a classic environmental pollutant, is reported to cause cardiotoxicity in animals and humans. It has been demonstrated that PFOS exposure down-regulates expression of cardiac-development related genes and p...
Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline [0.03%]
线粒体功能障碍和凋亡是佩希林引起的肝毒性的原因
Zhen Ren,Si Chen,Ji-Eun Seo et al.
Zhen Ren et al.
Perhexiline is an anti-anginal drug developed in the late 1960s. Despite its therapeutic success, it caused severe hepatoxicity in selective patients, which resulted in its withdrawal from the market. In the current study we explored the mo...
Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands [0.03%]
广义浓度相加模型在预测 glucocorticoid受体配体混合物效应中的应用
Rosemarie de la Rosa,Jennifer J Schlezinger,Martyn T Smith et al.
Rosemarie de la Rosa et al.
Environmental exposures often occur in complex mixtures and at low concentrations. Generalized concentration addition (GCA) is a method used to estimate the joint effect of receptor ligands that vary in efficacy. GCA models have been succes...
Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices [0.03%]
培养的小鼠和大鼠精准切割肠切片中上皮细胞的生存与细胞异质性研究
Carin Biel,Emilia Bigaeva,Melanie Hesse et al.
Carin Biel et al.
Precision-cut intestinal slices (PCIS) are used to study intestinal (patho)physiology, drug efficacy, toxicity, transport and metabolism ex vivo. One of the factors that limit the use of PCIS is a relatively short life-span. Moreover, cultu...
Simultaneous screening of the stability and dosimetry of nanoparticles dispersions for in vitro toxicological studies with static multiple light scattering technique [0.03%]
静态多重光散射技术在体外毒理学研究中对纳米颗粒分散体系稳定性和剂量同时筛查的方法
Matthias P L Sentis,Giovanni Brambilla,Valérie Fessard et al.
Matthias P L Sentis et al.
To evaluate the nanoparticle (NP) toxicity, much efforts have been devoted for developing methods to accurately disperse NPs into aqueous suspensions prior to in vitro toxicological studies. As NP toxicity is strongly dependent on their phy...
Ophiopogonin D suppresses TGF-β1-mediated metastatic behavior of MDA-MB-231 breast carcinoma cells via regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis [0.03%]
Xue Zhu,Ke Wang,Yu Chen
Xue Zhu
Ophiopogonin D, a steroidal glycoside extracted from the Traditional Chinese Medicine Ophiopogon japonicus, shows anti-tumor property in several lines of cancers; however, its effect on triple-negative breast cancer (TNBC) has not been inve...
Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons [0.03%]
电分析法和分光光度法对海马神经元原代培养物中异苯并呋喃酮抗氧化活性评价的联合应用
Aniely Dos Reis Teixeira,Róbson Ricardo Teixeira,Iara Mariana Lellis Ribeiro et al.
Aniely Dos Reis Teixeira et al.
The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called re...
Activation of NLRP3 inflammasome in hepatocytes after exposure to cobalt nanoparticles: The role of oxidative stress [0.03%]
肝细胞接触钴纳米粒子后NLRP3炎性体的激活：氧化应激的作用
Sisi Feng,Zhenyu Zhang,Yiqing Mo et al.
Sisi Feng et al.
With the increased use of nanomaterials and increased exposure of humans to various nanomaterials, the potential health effects of nanomaterials cannot be ignored. The hepatotoxicity of cobalt nanoparticles (Nano-Co) is largely unknown and ...
Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure [0.03%]
用于挥发性化合物接触点吸入毒性测试的体外方法开发，采用器官型培养和气液界面暴露技术
Artik Mistry,Larry E Bowen,Michael W Dzierlenga et al.
Artik Mistry et al.
In vitro chemical risk assessment using human cells is emerging as an alternative to in vivo animal testing with reduced costs, fewer animal welfare concerns, and the possibility of greater human health relevance. In vitro inhalation toxici...