Novel diphenyl urea derivative serves as an inhibitor on human lung cancer cell migration by disrupting EMT via Wnt/β-catenin and PI3K/Akt signaling [0.03%]
新型双苯基脲衍生物通过扰乱EMT及Wnt/β-连环蛋白和PI3K/Akt信号传导抑制人体肺癌细胞迁移
Bingling Dai,Mengying Fan,Runze Yu et al.
Bingling Dai et al.
Targeted anti-tumor small molecules are considered to be promising candidates for cancer treatment. The novel diphenyl urea derivative (DUD) was synthesized by the molecular docking based on the structure optimization of Taspine (a natural ...
Molecular fingerprints of conazoles via functional genomic profiling of Saccharomyces cerevisiae [0.03%]
通过酵母的功能基因组谱剖析康唑类分子指纹
Miao Guan,Pu Xia,Mingming Tian et al.
Miao Guan et al.
Conazoles were designed to inhibit ergosterol biosynthesis. Conazoles have been widely used as agricultural fungicides and are frequently detected in the environment. Although conazoles have been reported to have adverse effects, such as po...
Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells [0.03%]
BPA、BPS和BPF对体外小鼠和人T细胞IL-17分泌的差异影响
Yann Malaisé,Hélène Le Mentec,Lydie Sparfel et al.
Yann Malaisé et al.
The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases. Regulatory re...
Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples [0.03%]
基于96孔板的生物样本过氧化氢酶活力动力学检测方法的建立与发展
Luís F Grilo,João D Martins,Chiara H Cavallaro et al.
Luís F Grilo et al.
Oxidative stress biomarkers are powerful endpoints in toxicological research. Cellular reductive/oxidative balance affects numerous signaling pathways involving H2O2. Detoxification and control of H2O2 levels results mainly from catalase ac...
Toxicological analysis of aerosols derived from three electronic nicotine delivery systems using normal human bronchial epithelial cells [0.03%]
使用正常人支气管上皮细胞分析三种电子尼古丁传递系统的气溶胶的毒性
K Pearce,N Gray,P Gaur et al.
K Pearce et al.
Electronic nicotine delivery systems (ENDS) are a rapidly growing global market advertised as a safer alternative to combustible cigarettes. However, comprehensive investigations of END aerosol physicochemical and toxicological properties h...
Toxicogenomic study to identify potential signaling alterations related to nasal inflammatory damages induced by diesel exhaust particles in primary human nasal epithelial cells [0.03%]
毒物基因组学研究识别与柴油排气颗粒诱导的主要人类鼻上皮细胞的鼻炎性损伤相关潜在信号改变
Hyun Soo Kim,Hyo Jeong Kim,Nahyun Kim et al.
Hyun Soo Kim et al.
In this study, we aimed to identify signaling alteration caused by exposure to diesel exhaust particles (DEPs) using primary human nasal epithelial cells (PHNECs). Global gene expression profiles in PHNECs following 50 and 200 μg/ml of DEP...
The suitability of reconstructed human epidermis models for medical device irritation assessment: A comparison of In Vitro and In Vivo testing results [0.03%]
重建人表皮模型对医疗器械刺激性评价的适用性：体外和体内测试结果的比较
Wim H De Jong,Joseph W Carraway,Chenghu Liu et al.
Wim H De Jong et al.
The ISO 10993 standards on biocompatibility assessment of medical devices discourage the use of animal tests when reliable and validated in vitro methods are available. A round robin validation study of in vitro reconstructed human epidermi...
Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures [0.03%]
利用体外生物标志物根据致癌潜力对多环芳烃进行分类
Yvonne Chang,Celine Thanh Thu Huynh,Kelley M Bastin et al.
Yvonne Chang et al.
One of the most difficult challenges for risk assessment is evaluation of chemicals that predominately co-occur in mixtures like polycyclic aromatic hydrocarbons (PAHs). We previously developed a classification model in which systems biolog...
Epigenetic priming by EHMT1/EHMT2 in acute lymphoblastic leukemia induces TP53 and TP73 overexpression and promotes cell death [0.03%]
急性淋巴细胞白血病中EHMT1/ EHMT2的表观遗传活化诱导TP53和TP73过表达并促进细胞死亡
Amandda Évelin Silva-Carvalho,Ana Paula Dorneles Alencar,Marielly Reis Resende et al.
Amandda Évelin Silva-Carvalho et al.
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and EHMT2 are upregulated in various human cancers, and their deregulation is associated with tumor development and progression. In this paper, we investigated the expression level of...
Acute in vitro effects on embryonic rat dorsal root ganglion (DRG) cultures by in silico predicted neurotoxic chemicals: Evaluations on cytotoxicity, neurite length, and neurophysiology [0.03%]
基于计算机预测的神经毒性化学物质对体外胚胎大鼠背根神经节(DRG)培养物的急性影响：细胞毒性的评估，神经突长度和神经生理学
Andrew F M Johnstone,Cina M Mack,Matthew C Valdez et al.
Andrew F M Johnstone et al.
The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins, resulting in neurotoxicity. Twelve chemicals predicted to be neurotoxic were evaluated ...