Selective JAK-1 inhibitor Upadacitinib and peptide PD29 modulate the JAK and TGF-β/Smad signaling pathways reducing experimental dermal fibrosis [0.03%]
选择性JAK-1抑制剂Upadacitinib和肽PD29通过调节JAK和TGF-β/Smad信号通路减少实验性皮肤纤维化
Ayşe Koçak,Cemre Ural,Zahide Cavdar et al.
Ayşe Koçak et al.
This study investigates the antifibrotic and anti-inflammatory effects of Janus kinase (JAK) inhibitors and the PD29 peptide in the context of systemic sclerosis (SSc), a condition characterized by dermal thickening, chronic inflammation, a...
Cadmium sulfide nanoparticles (CdSNPs) modulate key oncogenic pathways in PA1 ovarian cancer cells: Insights from transcriptomic analysis [0.03%]
硫化镉纳米颗粒通过转录组分析调控PA1卵巢癌细胞中关键致癌通路的新见解
Aditi Bhatnagar,Abhay Dev Tripathi,Sonali Kumari et al.
Aditi Bhatnagar et al.
Transcriptomics has become a useful tool for comparing the levels of gene expression in healthy and malignant cells, holding potential for the discovery of new cancer therapies. This study used RNA-sequencing and transcriptome analysis on t...
Zinc finger transcription factor ZNF384 mitigates LPS-induced ferroptosis and inflammation in lung epithelial cells by activating SESN2-mediated autophagy [0.03%]
锌指转录因子ZNF384通过激活SESN2介导的自噬缓解LPS诱导的肺上皮细胞铁死亡和炎症
Lu Shi,Hongxue Fu,Yingting Hao et al.
Lu Shi et al.
Background: Ferroptosis, a type of programmed cell death distinct from apoptosis, is potentially associated with sepsis-triggered acute respiratory distress syndrome (ARDS). ZNF384 is a transcription factor, but its role ...
Cigarette sidestream smoke-induced cellular senescence and the protective role of histone H2AX [0.03%]
细胞衰老及组蛋白H2AX的保护作用
Yukako Komaki,Yuko Ibuki
Yukako Komaki
Cigarette smoke imposes serious health hazards such as cancer and cardiovascular diseases but is also associated with cellular senescence. Recently, histone loss and modifications are reported as one of the characteristics of cellular senes...
Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates [0.03%]
药物诱导的心力衰竭与CYP1A1、CYP1B1和CYP3A4抑制之间的关联：评估候选药物心毒性的细胞色素P450抑制检测的适用性
Shunnosuke Kaito,Kiyomi Sato,Takamitsu Sasaki et al.
Shunnosuke Kaito et al.
Unpredictable adverse drug reactions (ADRs) present a significant challenge in drug development and require advanced prediction systems for ADRs. Previously, we identified a connection between drug-induced liver injury (DILI) and the inhibi...
A549 cells exposed to a marijuana smoke extract affect mono-layer integrity related to oxidative stress state [0.03%]
暴露于大麻烟提取物的A549细胞单层完整性受到氧化应激状态的影响
Elvira Gómez-Guerrero,Yazmín Debray-García,Octavio Gamaliel Aztatzi-Aguilar et al.
Elvira Gómez-Guerrero et al.
Marijuana smoke contains several toxic compounds that may induce dysregulation of oxidative mechanisms and barrier system in airway alveolar cells. This study aimed to assess whether marijuana smoke extract (MSE) modifies mono-layer integri...
Acute toxicity and cardiotoxicity of Penthorum chinense pursh and gallic acid in zebrafish (Danio rerio) [0.03%]
蒲公英草和没食子酸的急性毒性和心脏毒性研究——斑马鱼模型分析
Kehui Liu,Hui Jiang,Rong Ji et al.
Kehui Liu et al.
Penthorum chinense Pursh (P. chinense), known for its anti-inflammatory and antioxidant properties, is valued for its low toxicity in animal and human models. However, concerns have arisen regarding the developmental effects of its bioactiv...
Guilin Wei,Chaohua Yan,Liwei Zou et al.
Guilin Wei et al.
Hydroxychloroquine (HCQ), a medication renowned for its anti-malarial and anti-autoimmune properties, is susceptible to drug-drug interactions (DDIs), particularly those involving cytochrome P450 enzymes (CYPs). The pharmacokinetic and meta...
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system [0.03%]
抗生素通过体外模型系统减少肠腔内胆汁酸的回吸收
Nina Zhang,Véronique M P de Bruijn,Weijia Zheng et al.
Nina Zhang et al.
Enterohepatic circulation of bile acids is a highly efficient process that is important for bile acid homeostasis. The aim of the present study was to characterize the impact of a series of antibiotics (lincomycin, streptomycin, vancomycin ...