Collaborative evaluation of in silico predictions for high throughput toxicokinetics [0.03%]
高通量毒代动力学的计算机预测联合评价方法研究进展
John Wambaugh,Nisha Sipes,Gilberto Padilla Mercado et al.
John Wambaugh et al.
High throughput toxicokinetic (HTTK) methods address chemical risk assessment data gaps but require chemical-specific values that can be obtained by in vitro measurements or in silico models. In this study, seven quantitative structure prop...
Binding of plutonium and americium to small molecular weight ligands favors their paracellular transfer across lung epithelium in vitro [0.03%]
钚和镅与小分子量配体结合有利于其通过体外肺上皮的旁细胞转运
G Drouet,A Bourgois,K Devilliers et al.
G Drouet et al.
Pulmonary absorption is a critical step in the time-dependent processes governing actinide biodistribution and toxicity following internal contamination by inhalation. The current study was undertaken to investigate on a simple in vitro Cal...
Synergistic and divergent effects of dietary sugars on hepatocyte viability and steatosis [0.03%]
膳食糖类物质对肝细胞存活率和脂肪变性作用的协同效应与相异效应
Ajay Kumar,Garhima Arora,Deepika Kumari et al.
Ajay Kumar et al.
Our study explores the effects of glucose, fructose, and sucrose on hepatocyte health, focusing on cell viability and lipid accumulation. Hepatocyte cells (HepG2) were exposed to a range of concentrations of glucose, fructose and sucrose, b...
Toxicity assessment of 6PPD-quinone in human lung cells: Insights from BEAS-2B and A549 cell lines [0.03%]
6PPD醌对人肺细胞毒性的评估：BEAS-2B和A549细胞系的见解
Saja Damdam,Blake Hunnie,Parker Jones et al.
Saja Damdam et al.
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), an environmental transformation product of the rubber tire antioxidant 6PPD, is increasingly detected in urban environments, yet its impact on human health. This study inv...
Use of resazurin-based metabolic assays as a continuous measure of viability in three-dimensional (3D) in vitro Cell Culture: A Study with Presto Blue™ [0.03%]
基于重氮化合物的代谢测定在三维细胞培养中的连续存活检测：以Presto Blue为研究对象
Veronica M Lucian,Robert C Carlisle,Constantin C Coussios et al.
Veronica M Lucian et al.
Testing cell viability in three-dimensional (3D) in vitro cell cultures is not always straightforward. Reduction-based metabolic assays have been suggested as a rapid, reportedly non-toxic mechanism for monitoring cell viability in continuo...
The emerging pollutants polycyclic aromatic compounds (PAH'S) bisphenol a (BPA), and phthalates impair immune system function: Effects on human macrophages [0.03%]
多环芳烃、双酚A及酞酸盐等新污染物影响免疫系统功能：对人体巨噬细胞的影响
K Bobadilla-Lozoya,J Morales-Montor,K G Mejía-Salgado et al.
K Bobadilla-Lozoya et al.
Human activity has led to the increment of diverse pollutants. Plastics have great practical value since they are present in everyday products. However, not only plastics have gained importance, but their plasticizers such as bisphenol A (B...
Excess curcumin causes cytotoxicity of its nanoconjugate with nanoceria [0.03%]
过量姜黄素导致其与纳米氧化铈的纳米缀合物细胞毒性增强
Nikita N Chukavin,Anton L Popov,Victoria A Anikina et al.
Nikita N Chukavin et al.
Curcumin is a natural bioactive substance with promising biomedical applications. However, the low solubility and stability of curcumin significantly limit its potential use. The development of nanoformulations of curcumin makes it possible...
NAM-based development of a predictive test model for evaluating skin mildness potential of rinse-off products via integrated in vitro assays [0.03%]
基于NAM的预测性测试模型的发展：通过体外整合试验评估洗落型产品皮肤温和性的潜力
Yi-Peng Ng,Mei-Leng Tee,Shi-Ngar Pang et al.
Yi-Peng Ng et al.
The Forearm Controlled Application Test (FCAT) is widely used to assess skin irritancy and drying potential of rinse-off product but limited by its low throughput and long testing duration. To address these limitations, we explored the deve...
Stronger prooxidative effects of chromium(VI) comparing to chromium(III) in endocrine and non-endocrine tissues with the thyroid being completely resistant to antioxidant protection [0.03%]
六价铬比三价铬具有更强的促氧化作用，且甲状腺组织完全不受抗氧化剂保护的作用影响
Aleksandra K Gładysz,Jan Stępniak,Laura López-Pingarrón et al.
Aleksandra K Gładysz et al.
Chromium (Cr) is a harmful heavy metal pollutant. Cr(VI) is a group 1 carcinogen (carcinogenic to humans), whereas Cr(III) is a group 3 carcinogen (not classifiable as to its carcinogenicity to humans). Cr is also documented to be an endocr...
Hyperuricemia impairs endothelial function through SMS2-dependent activation of the endoplasmic reticulum stress response [0.03%]
高尿酸血症通过SMS2依赖性激活内质网应激反应损伤内皮功能
Liyuan Wang,Ruifang Zhang,Xuelian Liu
Liyuan Wang
Hyperuricemia is a recognized risk factor for cardiovascular diseases, including peripheral arterial disease (PAD), though molecular mechanisms linking uric acid to endothelial dysfunction remain unclear. This study investigates the role of...