CiPA-qualified human iPSC-derived cardiomyocytes: A new frontier in toxicity testing by evaluating drug-induced arrhythmias [0.03%]
CiPA认证的人类诱导多能干细胞源性心肌细胞：通过评估药物诱发的心律失常进行毒性检测的新前沿
Vijay Bhaskar Reddy Konala,Rutuja Kuhikar,Shruti More et al.
Vijay Bhaskar Reddy Konala et al.
Drug-induced arrhythmias remain a significant challenge in drug development, often leading to serious cardiovascular complications and the withdrawal of approved drugs from the market. The Comprehensive in vitro Proarrhythmia Assay (CiPA) i...
Toxicoproteomic study of fipronil in SH-SY5Y cells reveals induction of endoplasmic reticulum stress and necrotic cell death as neurodegenerative mechanisms [0.03%]
毒蛋白组学研究发现氟尼农诱导SH-SY5Y细胞内质网应激和坏死性细胞死亡的神经退行性机制
Theetat Ruangjaroon,N Monique Paricharttanakul,Daranee Chokchaichamnankit et al.
Theetat Ruangjaroon et al.
Exposure to pesticides has been considered as a risk factor for developing neurodegenerative diseases. The increasing use of fipronil, a phenylpyrazole insecticide, poses a risk to human health. This study aims to use toxicoproteomics for e...
Chronic exposure to palmitic acid-induced adipocyte hypertrophy and altered batokine gene expression in T37i brown adipocytes [0.03%]
棕色脂肪细胞T37i中棕色脂肪因子基因表达的改变和软脂酸诱导的肥胖模型下脂肪细胞肥大的慢性暴露关系研究
Khanyisani Ziqubu,Phiwayinkosi V Dludla,Sithandiwe E Mazibuko-Mbeje
Khanyisani Ziqubu
Enlargement of adipose tissue through hypertrophy is a key hallmark of obesity. Our previous study demonstrated that chronic obesity induces brown adipose tissue hypertrophy and altered batokine gene expression patterns in vivo. The present...
Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing [0.03%]
基于TK6细胞系表达四种人细胞色素P450的株系发展用于遗传毒性试验
Xilin Li,Yuhan Wang,Hannah Xu et al.
Xilin Li et al.
Metabolism is essential for in vitro genotoxicity testing. We previously developed a panel of TK6 cell lines, each expressing one of 14 human cytochrome P450 (CYP) enzymes, demonstrating their ability to effectively bioactivate indirect gen...
Use of centromeric probe to identify micronuclei origin and its advantages in genetic toxicology studies [0.03%]
着丝粒探针识别微核起源及其在遗传毒理学研究中的优势
G Tamizh Selvan,P Venkatachalam
G Tamizh Selvan
Fluorescence in situ hybridization (FISH) and karyotyping have long been considered essential for chromosomal examination to analyse the stable chromosome aberrations such as translocations after exposure to genotoxic agents. To improve spe...
Transcriptomic dose-response by UVC and heavy ion radiation reveal pathways to immune impairment [0.03%]
UV-C和重离子辐射的转录组剂量响应变化揭示了导致免疫功能障碍的途径
Mingming Tian,Xiaolin Ding,Yue Pang et al.
Mingming Tian et al.
Irradiation-induced immune impairment has been linked to human immune diseases, such as myelodysplastic syndromes (MDS) and leukemia. Global molecular responses to genome instability in immune cells can be identified by using transcriptomic...
Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line [0.03%]
采用分子机制探讨地西他滨对DNMT基因调控及抑制重金属致膀胱癌细胞增殖作用的影响研究
Deepika Saini,Pankaj Kumar Chaudhary,Ganesh Kumar Verma et al.
Deepika Saini et al.
Heavy metals are pervasive environmental and occupational carcinogens known to induce cell proliferation. They influence a number of cellular processes, including proliferation, metabolism, apoptosis, and carcinogenesis. Among the several u...
Haemostasis-altering effects of Milos viper (Macrovipera schweizeri) venom [0.03%]
米尔奥斯矛头蝮毒液的止血作用效应研究
Ignazio Avella,Lennart Schulte,Maik Damm et al.
Ignazio Avella et al.
Haemotoxicity is one of the primary symptoms of viperid envenomation, manifesting in cardiovascular and haemostatic disturbances such as hypotension, haemorrhage, and coagulopathy. Bites by the Milos viper (Macrovipera schweizeri) have been...
Detection of skin sensitization hazards in medical device materials using a combination of three alternative in vitro testing methods [0.03%]
基于三种体外替代检测方法的医疗器械材料皮肤致敏危害筛查和确认检测
Masayuki Okada,Harumi Tabata,Keiki Suzuki et al.
Masayuki Okada et al.
This study attempted to detect the skin sensitization hazards of medical device materials by combining multiple in vitro alternative testing methods. Nine materials were extracted using organic solvents, and the re-dissolved solutions were ...
Gopinath Nallani,Appavu Chandrasekaran,Kelem Kassahun et al.
Gopinath Nallani et al.
In vitro intrinsic clearance of malathion was determined in adult and juvenile rat and human liver microsomes. Due to rapid elimination with no detectable levels of the parent, clearance rates of malathion were calculated from formation kin...