Inhibitory potential of phytochemicals on species-specific breast cancer resistance protein transport activity [0.03%]
植物化学物质针对物种特异性乳腺癌抗性蛋白转运活性的抑制潜能
Lérica le Roux-Pullen,Jeroen J M W van den Heuvel,Ilse R Dubbelboer et al.
Lérica le Roux-Pullen et al.
The use of herbal alternatives in modern agriculture and healthcare offers a sustainable approach to animal and human health, but raises concerns about safety, particularly regarding phytochemical interactions at membrane transport proteins...
Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model [0.03%]
采用三维人肝细胞球体模型评估大麻二酚联合丙戊酸或单独使用所致的肝脏损伤
Jessica L Beers,Shalon L Harvey,Raeanne M Geffert et al.
Jessica L Beers et al.
Cannabidiol (CBD) and valproate (VPA) are anti-epileptic medications commonly co-prescribed to treat seizures due to Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex in children. Clinical trial data have demonstrated...
Isolation and characterization of bovine Limbal mesenchymal stromal cells for application in ocular toxicity studies [0.03%]
角膜缘基质细胞的分离鉴定及其在眼部毒性研究中的应用
Martina Daniela Benedetti,Mariela Lenze,Mora Renée García et al.
Martina Daniela Benedetti et al.
Ocular toxicity assessment is essential to ensure the safety of chemicals and human-use products. Although the Draize test in rabbits has historically been the regulatory standard, it presents significant ethical and scientific limitations....
Employing histopathology to enhance the BCOP test: The emerging role of stromal thickness as a quantitative endpoint [0.03%]
利用组织病理学来增强BCOP试验：定量终点的间质厚度的作用日益重要
Martín Nicolás Rivero,Mariela Lenze,Martina Daniela Benedetti et al.
Martín Nicolás Rivero et al.
The Bovine Corneal Opacity and Permeability (BCOP) assay is a validated ex vivo method widely used to assess the ocular irritation potential of chemical substances. It is useful for identifying both chemicals that cause serious eye damage a...
Cytotoxic effects of a LED/UV nail polish dryer in human keratinocytes [0.03%]
LED/UV甲油干燥机对人角质细胞的细胞毒性作用
Alexandra Lopes,Patrícia Pereira,Helena Oliveira
Alexandra Lopes
Nail polish dryers are radiation-emitting devices designed to dry and cure nail polishes. These devices primarily emit radiation within the ultraviolet A (UVA) range, with some also emitting visible light, particularly those equipped with l...
Comparison of the behavior of human lung epithelial cell lines cultured at the air-liquid interface and assessment of their responses after benzo(a)pyrene exposure [0.03%]
人肺上皮细胞系体外培养方式及其苯并(a)芘暴露响应的比较研究
Suen Boulé,Louise Verhaeghe,Dominique Courcot et al.
Suen Boulé et al.
The biological effects of air pollution are still not well known, due to its complex mixture of particulate and gaseous compounds. In vitro cell culture models exposed at the air-liquid interface (ALI) represent a potential alternative to i...
Polystyrene nanoplastic co-exposed to BPA and BPS induces cytotoxicity, genotoxicity, and alters ROS production in HepG2 cells [0.03%]
聚苯乙烯纳米塑料与双酚A和双酚S联合作用于HepG2细胞中诱导细胞毒性、遗传毒性和改变ROS产生
Cecilia Cristina de Souza Rocha,Caroline Andolfato Sanchez,Marília Cristina Oliveira Souza et al.
Cecilia Cristina de Souza Rocha et al.
During plastic degradation, it is fragmented into micro and nanoplastic, which can adsorb contaminants from the environment, increasing the plastics´ toxicity. Bisphenol A is used in plastic production and can be an endocrine disruptor. Bi...
The neuroprotective role of chlorogenic acid and Fisetin in differentiated neuronal cell line-SHSY5Y against amyloid-β-induced neurotoxicity [0.03%]
氯ogenic酸和Fisetin通过抑制Tau过度磷酸化对抗Aβ诱导神经毒性的作用及其机制研究
Apoorv Sharma,Puneet Kumar,Asimul Islam et al.
Apoorv Sharma et al.
Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by amyloid-beta (Aβ) accumulation, synaptic dysfunction, oxidative stress, and lacks effective therapies. Fisetin and chlorogenic acid (CGA) are natural polyphenols...
Beyond traditional toxicology: The transformative power of PBTK modeling [0.03%]
超越传统毒理学：PBTK建模的变革力量
Anagha Damre,Aniruddha Banerjee
Anagha Damre
Physiologically Based Toxicokinetic (PBTK) modeling has emerged as a crucial tool in toxicokinetics, enabling the quantitative assessment of chemical absorption, distribution, metabolism, and excretion (ADME) across various biological syste...
Inter-laboratory validation study of an in vitro glucocorticoid receptor transactivation assay for testing potential endocrine disrupting chemicals [0.03%]
体外糖皮质激素受体转录激活分析的实验室间验证研究以测试潜在的内分泌干扰素
Andrea Rivero-Arze,Marina Grimaldi,Géraldine Maillet et al.
Andrea Rivero-Arze et al.
The glucocorticoid receptor (GR) belongs to the family of steroid receptors (SRs). These receptors regulate a vast selection of cell-, tissue-, and organism biology, and are also targets of endocrine disrupting chemicals warranting design a...