Commercial glyphosate formulations exceed active ingredient toxicity via mitochondrial ROS and transcriptomic disruption [0.03%]
商业化glyphosate配方通过线粒体ROS和转录组干扰超过活性成分的毒性作用
Jakeline Liara Teleken,Leticia Prates Roma,Rosane Aparecida Ribeiro et al.
Jakeline Liara Teleken et al.
Glyphosate (GLY) is among the most widely used pesticides globally. Emerging evidence suggests that GLY-based herbicides (GBHs) are more toxic than GLY alone. In this study, we used HepG2 cells expressing mitochondrial-targeted Hyper7 to mo...
Development of an in vitro acute respiratory toxicity test using the SoluAirway™, 3D human airway model [0.03%]
基于SoluAirwayTM的三维人体呼吸道模型的急毒性体外检测方法开发
Ji-Woo Choe,Geon-Hee Lee,Su-Hyun Lee et al.
Ji-Woo Choe et al.
This study presents a novel in vitro method for acute respiratory toxicity testing using the SoluAirway™ model (SoluAirway™ ARTT). SoluAirway™ is a 3D human airway tissue model constructed from primary human nasal epithelial cells, recap...
Anti-angiogenic effects of p,p'-Dichlorodiphenyldichloroethylene (p,p'-DDE) in the human microvasculature [0.03%]
p,p'-滴滴特[p,p'-DDE]对人类微血管的抗血管生成作用
Bulbul Ahmed,Melissa G Farb,Kimberly Chen et al.
Bulbul Ahmed et al.
p,p'-Dichlorodiphenyldichloroethylene (p,p'-DDE) is a primary and persistent metabolite of the pesticide dichlorodiphenyltrichloroethane. p,p'-DDE bioaccumulates in humans and has been associated with adverse health effects including endocr...
Evaluation of metal removal from skin exposed to stainless steel and cement particles: Insights from an in vitro permeation study [0.03%]
不锈钢和水泥颗粒接触皮肤的金属去除评价：源于体外透皮实验的启示
Greta Camilla Magnano,Veronique Malard,Matteo Crosera et al.
Greta Camilla Magnano et al.
Occupational exposure to metal-containing particles can pose significant risks to skin health, particularly in environments where materials such as stainless steel and cement are handled. This study evaluates the effectiveness of simple aqu...
Corrigendum to "Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species" [Toxicology in Vitro Volume 47, March 2018, Pages 8-17] [0.03%]
“乙烯二醇二甲基丙烯酸酯和乙二醇二甲基丙烯酸酯通过诱导活性氧对人类牙龈成纤维细胞产生细胞毒性和遗传毒性”[《体外毒理学》第47卷，2018年3月，第8-17页]的勘误表
Anna Bielecka-Kowalska,Piotr Czarny,Paulina Wigner et al.
Anna Bielecka-Kowalska et al.
Advances in thyroid hormone system disruption testing - In vitro method for monitoring disrupted thyrotropin signaling through the human TSH receptor (hTSHR) [0.03%]
甲状腺激素系统干扰检测方法的新进展——通过人类促甲状腺素受体（hTSHR）监测受损的促甲状腺素信号转导的体外方法
Markéta Dvořáková,Kristina Kejlová,Goffová Gabriela et al.
Markéta Dvořáková et al.
In recent years, increasing attention has been directed toward development of in vitro methods to assess thyroid hormone system disrupting chemicals suitable for regulatory applications. As a part of this effort, the EU Reference Laboratory...
CYP-mediated metabolic divergence underpins oxoglaucine selectivity: Detoxification in healthy hepatocytes versus mitochondrial apoptosis in hepatocellular carcinoma [0.03%]
由CYP介导的代谢差异决定了氧戊蓝的选择性：健康肝细胞中的解毒与肝癌细胞中的线粒体凋亡
Pinzheng Li,Hengbin Zhang,Yingchun Chen et al.
Pinzheng Li et al.
Oxoglaucine (OXO), an aporphine alkaloid derived from Corydalis yanhusuo, exhibits a broad spectrum of pharmacological activities, including antiviral, antifungal, antiplatelet, and anti-hepatic fibrosis effects, with particularly promising...
The Nrf2 activator tBHQ inhibits dendritic cell maturation and activation in response to bacterial and viral stimuli [0.03%]
Nrf2激活剂tBHQ抑制树突状细胞对细菌和病毒刺激的成熟和活化作用
Saamera Awali,Yining Jin,David M Duriancik et al.
Saamera Awali et al.
Dendritic cells (DCs) are professional antigen presenting cells that promote both innate and adaptive immune responses. Pertinent to adaptive immunity, DCs activate naïve T cells by presenting peptides on MHC class II molecules. Tert-butyl...
Assessment of ocular irritation potential of moisturizing and sunscreen cosmetic creams marketed in Algeria using the HET-CAM test [0.03%]
用HET-CAM试验评估阿尔及利亚市场上的保湿和防晒化妆品的ocular irritancy潜能
Mecheri Imane,Djafer Rachid,Belmahi Mohamed Habib
Mecheri Imane
Cosmetic products applied around the eyes, such as moisturizing and sunscreen creams, can come into contact with the conjunctiva, potentially causing irritation due to the thinness of the ocular epithelium. These products, widely used by th...
Particulate matter exposure-induced cholesterol metabolism dysregulation in lung epithelial cells [0.03%]
颗粒物暴露引起的肺上皮细胞胆固醇代谢紊乱
Huanxiang Li,Yimin Li,Xiaozhen Wang et al.
Huanxiang Li et al.
Particulate matter (PM) poses a significant threat to human health, yet its systemic impact on molecular networks and cellular toxicity remains poorly understood. RNA sequencing was employed to explore the molecular mechanisms of micrometer...