Assessing the skin sensitization potential of fragrance ingredients in consumer products using the peroxidase peptide reactivity assay (PPRA) as an additional weight of evidence [0.03%]
利用过氧化物酶多肽反应测定法（PPRA）评估消费品中的香料组分的皮肤致敏潜能作为证据权重的一部分
Isabella Schember,Isabelle Lee,Maura Lavelle et al.
Isabella Schember et al.
A fragrance ingredient's potential to induce skin sensitization is an important factor in risk assessment. The key events in the skin sensitization adverse outcome pathway (AOP) can be evaluated with new approach methodologies (NAMs) for ha...
Determination of physicochemical, cytotoxic, and whitening properties of plasma-activated liquids for their potential use as mouthwashes [0.03%]
等离子活化液的理化、细胞毒性及漂白性能测定及其作为漱口水的潜在应用评估
Angelika Banaszak,Magdalena Zyzak,Andrzej Wojnar et al.
Angelika Banaszak et al.
Multiple drug resistance (MDR) among antibiotic-resistant bacteria poses a major challenge in modern medicine, prompting interest in alternative antimicrobials like mouthwashes and toothpastes. Plasma-activated liquids (PALs), produced by e...
A549 and CI-hAELVi cell lines coculture as a new human alveolar epithelium model for air-liquid interface exposure [0.03%]
一种新的体外人类肺泡上皮屏障模型用于气液界面暴露研究
Aurelia Alunni,Ophélie Simonin,Guillaume Barbier et al.
Aurelia Alunni et al.
Air pollution represents a growing threat to human health, particularly affecting the respiratory system through the inhalation of gaseous pollutants and fine particles that reach the alveolar region composed mainly of alveolar epithelial t...
Role of CD163 in the mechanism of hydrophilic silica nanoparticle-induced pulmonary fibrosis [0.03%]
CD163在亲水性二氧化硅纳米粒子诱导的肺纤维化机制中的作用
Chaoya Ma,Yaotang Deng,Xiao Zhang et al.
Chaoya Ma et al.
Objective: Silicosis, a progressive pulmonary fibrosis caused by silica dust exposure, remains a global occupational health threat, particularly with the rising use of nano-silica (nano-SiO₂) in industries. This study ai...
Conditioned medium from 1-nitropyrene induced THP-1 foam cells promotes pro-tumorigenesis in lung epithelial cells [0.03%]
1-硝基荧蒽诱导的训练体外培养液可促进泡沫细胞向肿瘤表型转化
Ankita Bagde,Atul Katarkar,K Krishnamurthi
Ankita Bagde
Diesel exhaust (DE) is a major environmental pollutant containing fine particulate matter and polycyclic aromatic hydrocarbons (PAHs). Among its constituents, 1-nitropyrene (1NP) is a recognized surrogate marker of DE. Although 1NP is known...
Chemical characterisation and cytotoxic analysis of an electronic cigarette and heated tobacco product compared to a conventional cigarette in human lung cell lines [0.03%]
与传统卷烟相比，电子烟和加热不燃烧烟草产品的人类肺细胞系中的化学特征及细胞毒性分析
Gregory Rankin,Håkan Wingfors,Linda Öberg et al.
Gregory Rankin et al.
The use of electronic nicotine delivery systems, such as e-cigarettes and heated tobacco products (HTPs), is increasing, but knowledge of their short and long-term toxicological effects remains limited. Here, aerosols generated from an e-ci...
Using a reconstructed human vaginal epithelium to assess irritation: A proof-of-concept study supporting regulatory qualification of the method for use with personal lubricants [0.03%]
使用重建的人类阴道上皮评估刺激作用：一项概念验证研究，支持该方法用于个人润滑剂的监管认定
Jessica Perrin,Gertrude-Emilia Costin,Seyoum Ayehunie et al.
Jessica Perrin et al.
Consumers tend to think of personal lubricants as personal care products or cosmetics that are not tested using animals, but the regulatory classification and hence the testing requirements for these products vary by country. For example, i...
Vitamin E acetate and its aerosol activate aryl hydrocarbon receptor signaling and exacerbate inflammation in human U937-derived macrophages [0.03%]
乙酰左旋维生素E及其气溶胶激活人U937源性巨噬细胞中的芳香烃受体信号并加重炎症反应
Xiaohan Li,Andrea Rossi,Thomas Haarmann-Stemmann et al.
Xiaohan Li et al.
In 2019, a number of patients were hospitalized after the use of electronic cigarettes and displayed acute lung injuries. Such injury was categorized as e-cigarette or vaping associated lung injury (EVALI). Among these patients, Vitamin E a...
Effects of cyanobacterial metabolites and their mixtures on biomarkers of oxidative stress in RTgill-W1 cells [0.03%]
蓝藻代谢产物及其混合物对RTgill-W1细胞氧化应激生物标志物的影响
Adam Bownik,Barbara Pawlik-Skowrońska
Adam Bownik
The aim of our investigation was to determine the effects of seven cyanobacterial metabolites microcystin-LR (MC-LR), anabaenopeptin-A (ANA-A), cylindrospermopsin (CYL), anabaenopeptin-B (ANA-B) aeruginosin 98 A (AER-A), aeruginosin 98B (AE...
Dual effects of metformin and resveratrol on compromising viability of endometrial cancer cells [0.03%]
二甲双胍和白藜芦醇联合使用对子宫内膜癌细胞活力的影响
Henrique Leal de Oliveira,Sara Hartke,Victória Borgmann A de Souza et al.
Henrique Leal de Oliveira et al.
Raising of mitogenic and anti-apoptotic agents - such as insulin, insulin-like growth factor type 1, and estrogen - during obesity and diabetes mellitus (types 1 and 2) favors the endometrial cancer (EC) development. Metformin, commonly use...