Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules [0.03%]
利用人源结肠类器官单层细胞作为体外平台研究小分子的积累、毒性及药动学效应
Pedro G M Canhão,Anny Smeuninx,Suzy Geerinckx et al.
Pedro G M Canhão et al.
The purpose of this study was to evaluate differentiated human colonoid-derived monolayers (hCDMs) as an in vitro platform for investigating small molecule accumulation, toxicity, and pharmacodynamics (PD), in comparison to Caco-2 monolayer...
In vitro effects of polystyrene microplastics exposure on adipose tissue dysfunction [0.03%]
体外暴露于聚苯乙烯微塑料对脂肪组织功能障碍的影响
Maria Sofia Molonia,Santi Trischitta,Federica Lina Salamone et al.
Maria Sofia Molonia et al.
Microplastics (MPs) are ubiquitous plastic particles with significant human health concerns due to their widespread distribution in the environment. The present study aims to evaluate the impact of exposure to polystyrene (PS) MPs (5 μm) o...
Assay integration for reproducible toxicity testing of particulate matter in a single well: cytotoxicity, oxidative stress, inflammatory response, and mRNA profiling [0.03%]
一次性孔板中颗粒物重复性毒性试验的检测整合：细胞毒性、氧化应激、炎症反应及mRNA表达谱分析
Andres Henriquez,Marjolaine Godbout-Cheliak,Alain Filiatreault et al.
Andres Henriquez et al.
Airborne particulate matter (PM) is an important risk factor for mortality. Accordingly, toxicity testing is needed to identify potency determinants. As PM mass is often limited, especially for environmental samples, integrated assessment o...
ESTIV early career network: A growing initiative to support the next generation of NAMs-oriented toxicologists [0.03%]
ESTIV早期职业网络：一项不断发展的计划，旨在支持下一代以NAMS为导向的毒理学家
Mohamed F Abdallah,Luiz Ladeira,Peter Pôbiš et al.
Mohamed F Abdallah et al.
Epigenetic regulation of intestinal innate immunity during differentiation of Caco-2 cells under inflammatory stress [0.03%]
炎症刺激下Caco-2细胞分化过程中表观遗传学调控肠固有免疫机制的研究
Ippei Uemura,Natsuko Takahashi-Suzuki,Takashi Satoh
Ippei Uemura
The intestinal epithelium supports antimicrobial programs and epithelial barrier function; while epigenetic mechanisms are increasingly implicated in these processes, how the differentiation stage shapes epigenetic regulation of key innate ...
Toxicological profiling of nutraceutical-grade curcumin-loaded solid lipid nanoparticles using Caco-2 cells and zebrafish (Danio rerio) embryo models [0.03%]
基于CACO-2细胞和斑马鱼胚胎模型的药用姜黄素固体脂质纳米粒毒理学谱研究
Raquel F S Gonçalves,Joana Ribeiro,Joana T Martins et al.
Raquel F S Gonçalves et al.
The development of bio-based nanostructures to encapsulate bioactive compounds represents a promising approach for creating functional foods with improved nutritional and health benefits. However, their regular dietary use raises safety con...
Hazard associated with the synthesis of epoxy-vitrimer: In vitro risk assessment and scoring strategy [0.03%]
环氧-粘合剂合成相关的风险：体外风险评估与评分策略
Marion Berenguer,David Béal,Justine Bétemps et al.
Marion Berenguer et al.
In the framework of a Safe, Sustainable, and Recyclable by Design approach for the synthesis of novel plastics, we investigated the toxicological impact of epoxy vitrimers' synthesis. Emphasis was placed on the substitution of conventional ...
Single-cell RNA sequencing of human embryonic stem cells reveals immediate and deferred transcriptomic responses to retinoic acid-mediated effects across cell subpopulations [0.03%]
单细胞RNA测序揭示了视黄酸介导的人胚胎干细胞亚群分化过程中的即时与延迟转录组响应
Sarah Park,David Gallegos,Susan Jeffay et al.
Sarah Park et al.
Identifying chemical-mediated molecular signatures may provide nuanced insights into early developmental processes, characterized by plasticity, rapid growth, and differentiation. This requires increased resolution of the multiple cell stat...
Organ-specific in vitro models for prediction of hazard assessment of nanomaterials [0.03%]
用于纳米材料风险评估的器官特异性体外模型预测研究
Laura Maria Azzurra Camassa,Elisabeth Elje,Sergey Shaposhnikov et al.
Laura Maria Azzurra Camassa et al.
Organ-specific multicellular in vitro models are used to mimic the lung-blood-brain axis, and to assess the nanomaterials (NMs) safety in humans. We employed a triculture lung model, a whole-blood model, an astrocytes-neurons coculture to e...
Contributing to a (cell) cultural shift: Human platelet lysate is a suitable replacement for fetal calf serum when culturing the HTR8/SVneo extravillous trophoblast cell line [0.03%]
为HTR8/SVneo侵袭性滋养细胞培养寻找胎牛血清的替代品：人血小板裂解物更适合
B C Hameete,A Hogenkamp,L Groenink
B C Hameete
While suitable as a universal supplement in cell culture, fetal calf serum (FCS) has several downsides, including its bovine origin and batch-to-batch variability. In this study, we investigated human platelet lysate (HPL) as a potential re...