Acute toxicity and cardiotoxicity of Penthorum chinense pursh and gallic acid in zebrafish (Danio rerio) [0.03%]
蒲公英草和没食子酸的急性毒性和心脏毒性研究——斑马鱼模型分析
Kehui Liu,Hui Jiang,Rong Ji et al.
Kehui Liu et al.
Penthorum chinense Pursh (P. chinense), known for its anti-inflammatory and antioxidant properties, is valued for its low toxicity in animal and human models. However, concerns have arisen regarding the developmental effects of its bioactiv...
Guilin Wei,Chaohua Yan,Liwei Zou et al.
Guilin Wei et al.
Hydroxychloroquine (HCQ), a medication renowned for its anti-malarial and anti-autoimmune properties, is susceptible to drug-drug interactions (DDIs), particularly those involving cytochrome P450 enzymes (CYPs). The pharmacokinetic and meta...
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system [0.03%]
抗生素通过体外模型系统减少肠腔内胆汁酸的回吸收
Nina Zhang,Véronique M P de Bruijn,Weijia Zheng et al.
Nina Zhang et al.
Enterohepatic circulation of bile acids is a highly efficient process that is important for bile acid homeostasis. The aim of the present study was to characterize the impact of a series of antibiotics (lincomycin, streptomycin, vancomycin ...
Corrigendum to "Tetrazolium-based colorimetric assays underestimat the direct antitumor effects of bevacizumab" [Toxicology in vitro 91 (2023) 105631] [0.03%]
关于“四唑比色测定法低估了贝伐单抗的直接抗肿瘤作用”的勘误说明（载于《体外毒理学》第91卷（2023年）105631页）
Pei Wei,Min Wang,Mao Lin et al.
Pei Wei et al.
Integrative toxicity assessment of tocotrienol-rich fraction from palm oil using in silico methods and zebrafish embryotoxicity model [0.03%]
基于掌油托可汀醇富集组分的整合毒性评估：结合计算机模拟和斑马鱼胚胎模型的方法
Thenmoly Damodaran,Najib Sani Yahaya,Mohd Nizam Mordi
Thenmoly Damodaran
Tocotrienol-rich fraction (TRF), a natural form of vitamin E derived from palm oil, possesses antioxidant properties. However, its potential embryonic developmental toxicity remains unclear. This study investigated TRF's toxicity using in s...
Ozone and particulate matter co-exposure at the air-liquid interface: Establishing an approach to assess pollutant interactions in vitro [0.03%]
臭氧和颗粒物联合暴露的空气液体界面模型：建立一种体外评估污染物相互作用的方法
Andres Henriquez,Marjolaine Godbout-Cheliak,Alain Filiatreault et al.
Andres Henriquez et al.
Background: Air pollution is a complex mixture of gases and particulates that varies spatially and temporally, making attribution of adverse effects to specific individual air pollutants a challenge. To disentangle effect...
The effect of organic solvents on the in vitro transport activity of three OATP isoforms [0.03%]
有机溶剂对三种OATP亚型的体外转运活性的影响
Rina Saito,Takeshi Akiyoshi,Kazunari Tsujii et al.
Rina Saito et al.
Purpose: In vitro studies of transporter activity often require the addition of organic solvents such as dimethyl sulfoxide (DMSO), methanol, and ethanol, to dissolve substrates and/or inhibitors. Although this may attenu...
The cyanobacterial toxins BMAA and 2,4-DAB perturb the l-serine biosynthesis pathway and induce systemic changes in energy metabolism in human neuroblastoma cells: A proteomic study [0.03%]
蓝藻毒素BMAA和2,4-DAB扰动L-丝氨酸生物合成途径并引起人神经母细胞瘤细胞能量代谢的系统变化：蛋白质组学研究
Lisa Pu,Joel R Steele,Connor R Phillips et al.
Lisa Pu et al.
Blue-green algae (cyanobacteria), an ancient phylum of bacteria, produce a wide array of secondary metabolites that are toxic to humans. Rapid growth of cyanobacteria in an aquatic environment can result in algal blooms capable of turning w...
Inhibition of JAK2/STAT3 by pacritinib synergizes with chemotherapy in esophageal carcinoma [0.03%]
JAK2/STAT3的抑制剂pacritinib与化疗药物联用在食管癌治疗中具有协同作用
Lan Han,Yinyin Sun,Kai Yang et al.
Lan Han et al.
The poor outcomes associated with esophageal carcinoma, particularly in advanced stages, necessitate the development of new treatment strategies. This study examines the efficacy of pacritinib, a multi-kinase inhibitor, both alone and in co...
Effects of 17β-estradiol and estrogen receptor subtype-specific agonists on Jurkat E6.1 T-cell leukemia cells [0.03%]
雌二醇和雌激素受体亚型特异性激动剂对Jurkat E6.1 T细胞白血病细胞的影响
Rahul S Nair,Mantavya N Patel,Thangamani Kannan et al.
Rahul S Nair et al.
Background: Estrogen signaling plays a crucial role in immune regulation and cancer metabolism, yet its impact on T-cell leukemia remains unclear. In hematological malignancies, estrogen receptor (ER) activation may influ...