An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals [0.03%]
一项关于IL-2 Luc检测法国际验证的研究：评估化学品对T细胞潜在免疫毒效应以及为免疫毒物提出参考数据的建议
Yutaka Kimura,Rie Yasuno,Mika Watanabe et al.
Yutaka Kimura et al.
To evaluate the immunotoxic effects of xenobiotics, we have established the Multi-ImmunoTox assay, in which three stable reporter cell lines are used to evaluate the effects of chemicals on the IL-2, IFN-γ, IL-1β and IL-8 promoters. Here,...
A proposed eye ex vivo permeation approach to evaluate pesticides: Case dimethoate [0.03%]
一种评估农药眼用渗透性方法的体外研究：以灭多威为例
Thalita Pedon de Araujo Cardoso,Juliana Kishishita,Asley Thalia Medeiros Souza et al.
Thalita Pedon de Araujo Cardoso et al.
This study aims to propose different ex vivo methodologies for pesticide evaluation when in contact with ocular mucosa. The first ex vivo study was performed using vertical Franz cells with fresh and refrigerated excised bovine corneas. The...
Skin sensitisation testing in practice: Applying a stacking meta model to cosmetic ingredients [0.03%]
皮肤过敏试验实践：将堆积集成模型应用于化妆品原料中
Fleur Tourneix,Nathalie Alépée,Ann Detroyer et al.
Fleur Tourneix et al.
Recently, several non-animal approaches contributing to the identification of skin sensitisation hazard have been introduced. Their validation and acceptance has largely been directed towards regulatory classification. Considering the drivi...
MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells [0.03%]
MicroRNA-486-5p通过调节MAGI1/Rap1/RASSF5信号通路促进对二羟基苯甲醚诱导的K562细胞红系分化抑制作用
Xiaoju Ma,Xue Zhang,Jiao Luo et al.
Xiaoju Ma et al.
Bone marrow failure is a characteristic effect of benzene exposure. Our previous study has shown that miR-486-5p is involved in benzene induced-suppression of erythroid differentiation. However, the mechanism of miR-486-5p to initiate the a...
Altered molecular pathways decides the treatment outcome of Hsp90 inhibitors against breast cancer cells [0.03%]
分子途径改变决定Hsp90抑制剂治疗乳腺癌细胞的效果
Naga Gowthami Vykuntham,Sourabh Suran,Satish Siripini et al.
Naga Gowthami Vykuntham et al.
The altered molecular pathways in response to chemotherapeutic interventions impose limitations on breast cancer treatments. Therefore, understanding the outcome of these alternative pathways may help in improving the chemotherapy. In this ...
Exposure of low-concentration arsenic induces myotube atrophy by inhibiting an Akt signaling pathway [0.03%]
低浓度砷暴露通过抑制Akt信号途径诱导肌管萎缩
Chen-Yuan Chiu,Min-Ni Chung,Kuo-Cheng Lan et al.
Chen-Yuan Chiu et al.
Arsenic, a widely distributed toxic metalloid, has been found to be associated with the low-birth-weight infants and the impairment of muscle regenerative capacity in areas with high levels of arsenic in drinking water. The distal muscular ...
CdTe and CdTe@ZnS quantum dots induce IL-1ß-mediated inflammation and pyroptosis in microglia [0.03%]
CdTe和CdTe@ZnS量子点诱导小胶质细胞中IL-1β介导的炎症和pyroptosis
Xue Liang,Tianshu Wu,Yan Wang et al.
Xue Liang et al.
CdTe quantum dots (QDs) are still widely considered as excellent fluorescent probes because of their far more superior optical performance and fluorescence efficiency than non‑cadmium QDs. Thus, it is important to find ways to control thei...
Anti-melanoma potential of two benzoquinone homologues embelin and rapanone - a comparative in vitro study [0.03%]
_embelin和ranphone的抗黑素瘤潜力比较研究
Dagmara Wróbel-Biedrawa,Karolina Grabowska,Agnieszka Galanty et al.
Dagmara Wróbel-Biedrawa et al.
Rapanone and embelin are simple alkyl benzoquinone derivatives, mainly distributed in the Primulaceae. They have an interesting scope of biological activities including cytotoxicity. As melanoma is one of the most common types of cancer, in...
Nonhomologous end joining and homologous recombination involved in luteolin-induced DNA damage in DT40 cells [0.03%]
芹菜素通过非同源末端连接和同源重组诱导DNA损伤及其作用机制研究
Cuifang Xiang,Xiaohua Wu,Zilu Zhao et al.
Cuifang Xiang et al.
Luteolin (3',4',5,7-tetrahydroxyflavone), a naturally occurring flavonoid, has been shown to have anticancer activity in many types of cancer cell lines. The anticancer capacity of luteolin may be related to its ability to induce DNA double...
In vitro toxicological characterisation of the antifungal compound soybean toxin (SBTX) [0.03%]
大豆毒素(SBTX)体外毒性表征
Mariana Reis Arantes,Ad Peijnenburg,Peter J M Hendriksen et al.
Mariana Reis Arantes et al.
Soybean toxin (SBTX) is a protein isolated from soybean seeds and composed of two polypeptide subunits (17 and 27 kDa). SBTX has in vitro activity against phytopathogenic fungi such as Cercospora sojina, Aspergillus niger, and Penicillium h...