The selected epigenetic effects of aminomethylphosphonic acid, a primary metabolite of glyphosate on human peripheral blood mononuclear cells (in vitro) [0.03%]
氨基甲基膦酸的表观遗传效应及其选择性：一种除草剂甘氟的主要代谢产物对人外周血单个核细胞（体外）的影响
Ewelina Woźniak,Edyta Reszka,Ewa Jabłońska et al.
Ewelina Woźniak et al.
Aminomethylphosphonic acid (AMPA) is a primary metabolite of glyphosate and amino-polyphosphonate. We have determined the effect of AMPA on selected epigenetic parameters and major cell cycle drivers in human peripheral blood mononuclear ce...
A comparative in vitro toxicity assessment of electronic vaping product e-liquids and aerosols with tobacco cigarette smoke [0.03%]
电子烟烟液和烟草烟雾的体外毒性比较评估
R Wieczorek,G Phillips,L Czekala et al.
R Wieczorek et al.
The use of electronic vaping products (EVPs) continues to increase worldwide among adult smokers in parallel with accumulating information on their potential toxicity and relative safety compared to tobacco smoke. At this time, in vitro ass...
MicroRNA-106b-5p participates in lead (Pb2+)-induced cell viability inhibition by targeting XIAP in HT-22 and PC12 cells [0.03%]
微核糖核酸-106b-5p通过靶向XIAP参与Pb2+致HT-22和PC12细胞活力抑制作用
Chong Xue,Beipei Kang,Peng Su et al.
Chong Xue et al.
Previous studies reported perturbed expressing of X-linked inhibitor of apoptosis protein (XIAP) under lead (Pb) exposure. However, researches on XIAP expression mainly focused on its transcriptional and post-translational regulation, rarel...
Inorganic fraction of oil sands process-affected water induces mammalian macrophage stress gene expression and acutely modulates immune cell functional markers at both the gene and protein levels [0.03%]
油砂工艺受污染水的无机组份可诱导哺乳动物巨噬细胞应激基因表达并急性改变免疫细胞功能分子标志物（从基因和蛋白质水平观察）
Nicole A I Phillips,Dustin M E Lillico,Rui Qin et al.
Nicole A I Phillips et al.
The focus of the present study was to examine the acute immunotoxic properties of oil sands process-affected waters (OSPW) using the RAW 264.7 macrophage cell line. Specifically, we used a quantitative PCR assay to monitor changes in the ex...
Development of a co-culture model of mouse primary hepatocytes and splenocytes to evaluate xenobiotic genotoxicity using the medium-throughput Comet assay [0.03%]
小鼠原代肝细胞和脾细胞共培养体系的建立及其在介质通量彗星实验中的应用研究
Tao Meng,Man Zhang,Jiayang Song et al.
Tao Meng et al.
To date, only a limited number of toxicological studies have focused on the establishment and validation of in vitro genotoxicity screening systems using primary hepatocytes, and the results of these studies have been inconsistent. Therefor...
An engineered non-erythropoietic erythropoietin-derived peptide, ARA290, attenuates doxorubicin induced genotoxicity and oxidative stress [0.03%]
一种非促红细胞生成素衍生物ARA290肽可减轻多柔比星所致的遗传毒性及氧化应激损伤作用
Mohammad Shokrzadeh,Mahmoud Etebari,Nasrin Ghassemi-Barghi
Mohammad Shokrzadeh
Erythropoietin (EPO) applies anti-inflammatory, anti-apoptotic, anti-oxidant and cytoprotective effects besides its hematopoietic action. A nonhematopoietic peptide engineered from EPO, ARA 290, interacts selectively with the innate repair ...
Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells [0.03%]
一种新的重组细胞系的开发用于在完整细胞中检测和表征Ah受体核转位
Ai Hayashi,Michael S Denison
Ai Hayashi
The Ah receptor (AhR) is a ligand-dependent transcriptional factor that mediates the effects of structurally diverse chemicals. Ligand binding stimulates nuclear translocation of the AhR and leads to AhR DNA binding and increased gene expre...
Benzofuran pyran compound rescues rat and human osteoblast from lipotoxic effect of palmitate by inhibiting lipid biosynthesis and promoting stabilization of RUNX2 [0.03%]
苯并呋喃吡喃化合物通过抑制脂质生物合成和促进RUNX2稳定来拯救棕榈酸盐的毒害效应以保护大鼠和人成骨细胞
Ashish Kumar Tripathi,Divya Rai,Priyanka Kothari et al.
Ashish Kumar Tripathi et al.
Obesity and ageing increases bone marrow fat which in turn is associated with lower bone mass. Marrow adipocytes by secreting cytokines, adipokines and free fatty acids change the bone marrow milieu and thus the number of osteoblasts. Palmi...
Comparison of experimentally measured and computational fluid dynamic predicted deposition and deposition uniformity of monodisperse solid particles in the Vitrocell® AMES 48 air-liquid-interface in-vitro exposure system [0.03%]
体内体外联合细胞 Ames48 系统中单分散固体颗粒沉降和均匀性的实验研究与 CFD 预测比较
Michael J Oldham,Nicolas Castro,Jingjie Zhang et al.
Michael J Oldham et al.
Accurately determining the delivered dose is critical to understanding biological response due to cell exposure to chemical constituents in aerosols. Deposition efficiency and uniformity of deposition was measured experimentally using monod...