Transcript-protein discrepancy of glutamatergic receptor subunits in human iPSC-derived neurons: Implications for neurotoxicity testing [0.03%]
人多能干细胞来源神经元中谷氨酸受体亚单位的转录本-蛋白差异及其对神经毒性检测的影响
Melania Maria Serafini,Miriam Midali,Giacomo Grumelli et al.
Melania Maria Serafini et al.
The development of robust human in vitro models is crucial for advancing neurotoxicology and reducing animal testing. Human-induced pluripotent stem cell (hiPSC)-derived neuronal models hold great promise, but still show limitations in reca...
Busulfan Plus Cyclophosphamide Induced Spermatogenic Dysfunction and Recovery: A Dynamic Change Perspective [0.03%]
苯达莫司汀联合环磷酰胺诱导的生精功能障碍及其恢复：动态变化视角分析
Tianyu Li,Zhichen Tang,Yaping Song et al.
Tianyu Li et al.
Busulfan combined with cyclophosphamide (BuCy) is a common conditioning regimen before hematopoietic stem cell transplantation, but it causes severe gonadotoxicity, with nearly half of male patients suffering from irreversible infertility. ...
MicroRNA-based Discrimination of hepatotoxic and non-hepatotoxic drugs using a humanized liver mouse model [0.03%]
基于microRNA的肝毒性药物筛选用人源化肝脏小鼠模型检测
Naoto Okada,Enomoto Hatsune,Ryota Goto et al.
Naoto Okada et al.
Drug-induced liver injury (DILI) is one of the most common adverse drug effects and a major cause of drug development failure. However, preclinically identifying drugs that cause liver injury remains difficult and represents a major challen...
Corrigendum to "Mechanisms, pathological features, and intervention strategies for nitrogen mustard-induced skin toxicity" [Toxicol. Lett. 416 (2026) 111815] [0.03%]
关于“氮芥所致皮肤毒性的机制、病理特征及干预策略”的勘误[T Xenotranspl 32(2) e12417]
Bing Zhu,Guanchao Mao,Qinghe Meng et al.
Bing Zhu et al.
Published Erratum
Toxicology letters. 2026 Jan 21:111831. DOI:10.1016/j.toxlet.2026.111831 2026
Role of mitochondrial biogenesis in methanol-induced neurobehavioral changes in rats [0.03%]
线粒体生物合成在甲醇致大鼠神经行为损伤中的作用研究
Guoping Li,Xiaohong Du,Xinqiao Wang et al.
Guoping Li et al.
Objective: This study aimed to explore the role of mitochondrial biogenesis in methanol-induced neurobehavioral impairments in rats and elucidate the potential neurotoxic mechanisms of methanol exposure. ...
The novel PFOS substitute OBS induces visual developmental toxicity in zebrafish embryos via ferroptosis [0.03%]
新型PFOS替代品OBS通过铁死亡诱导斑马鱼胚胎视觉发育毒性
Xing Liu,Xinyi Wu,Mingzhu Xia et al.
Xing Liu et al.
Sodium p-perfluorous nonenoxybenzenesulfonate (OBS), a widely used substitute for perfluorooctanesulfonic acid, may threaten ocular development, but its mechanisms remain unclear. In this study, zebrafish embryos were exposed to OBS (0, 0.0...
Occupational Lead Exposure Induces Oxidative Stress, Pulmonary Dysfunction, and Reduced Exercise Capacity: A Cross-Sectional Study [0.03%]
职业性铅暴露诱导氧化应激、肺功能下降和运动能力降低：横断面研究
Ukbe Sirayder,Cihangir Acik
Ukbe Sirayder
Aim: This study aimed to evaluate the effects of occupational lead exposure on exercise capacity, oxidative stress, and pulmonary function using a multisystemic approach. ...
Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor α-positive breast cancer cells [0.03%]
镉通过干扰福美司坦的抑瘤作用而促进内分泌耐药性雌激素受体α阳性乳腺癌细胞增殖
Koki Kanameda,Masayo Hirao-Suzuki,Shuso Takeda
Koki Kanameda
Fulvestrant (FUL), an estrogen receptor α (ERα)-degradative anti-estrogen, is used alone or in combination with cyclin-dependent kinase 4/6 inhibitors for the treatment of advanced ERα-positive breast cancer (BC) in postmenopausal women....
Piecing Together the Puzzles: Aryl Hydrocarbon Receptor-Mediated Genetic and Epigenetic Signatures in Dioxin-Induced Carcinogenicity- A Systematic Review and Meta-Analysis [0.03%]
破解旋涡：二恶英诱导致癌性的芳香烃受体介导的遗传和表观遗传特征的系统评价和荟萃分析
A Hefnawy Ahmad,Siam Mohamed,Mofarih Y Alkhaldi et al.
A Hefnawy Ahmad et al.
Background: Dioxins, are highly potent environmental carcinogens. Their toxic effects are mediated primarily by the Aryl Hydrocarbon Receptor (AhR). A comprehensive understanding of how AhR-induced genetic and epigenetic ...
Rubber-Derived Contaminants N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone Alter Intergenerational Cholesterol Metabolism in F1 Offspring of Exposed Mice [0.03%]
橡胶衍生污染物N-(1,3-二甲基丁基)-N'-苯基对苯二胺及其醌类衍生物可致暴露小鼠F1代子代胆固醇代谢紊乱
Liya Fang,Chanlin Fang,Shanshan Di et al.
Liya Fang et al.
This study examined the hepatic effects of parous exposure to the rubber-derived contaminant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6P...