Association of urinary heavy metals with osteoporosis in US adults using interpretable machine learning [0.03%]
基于可解释机器学习的美国成人骨质疏松症与尿液重金属暴露关联研究
Weihuan Huang,Dongpei Liu,Gang Liu et al.
Weihuan Huang et al.
Background: Exposure to heavy metals in the environment has always been the focus of public concern. More and more evidence suggests that heavy metal exposure may lead to bone degeneration and an increased risk of patholo...
Triclosan's interference with endocrine signalling: A mechanistic investigation [0.03%]
三氯生干扰内分泌信号：机制研究
Deepa Sharma,Tarang Kumar Shah,Reshma Sinha
Deepa Sharma
The triclosan (TCS) has been widely used as an antimicrobial and antibacterial agent in personal care products, medical, acrylic, veterinary, and household items. Owing to its capacity to interfere with hormone-regulated pathways, it has be...
Heavy Metal Exposure and Cancer Risk: Findings from a Mendelian Randomization Study [0.03%]
遗传学随机对照研究中重金属暴露与癌症风险的关系
Shuang Qin,Longhui Xie,Jianwei Lan et al.
Shuang Qin et al.
Background: Epidemiological evidence has established associations between heavy metal exposure and increased risks of various cancers. However, causality remains difficult to establish in conventional observational studie...
Bisphenol S and F Disrupt Cerebellar Functions and Neuronal Health: The Role of Estrogen Receptor and BMP2 Signaling [0.03%]
双酚S和F干扰小脑功能及神经元健康：雌激素受体和BMP2信号的作用
Uttara Das,Neetu Shukla,Deeksha Ojha et al.
Uttara Das et al.
Bisphenol S (BPS) and bisphenol F (BPF) have gained attention as endocrine disruptors that affect brain functions, with their specific impact on the cerebellum being less thoroughly explored. Estrogen receptors (ERs) are crucial in maintain...
Association between perfluoroalkyl and polyfluoroalkyl substances exposure and reproductive longevity for female in the United States: A population-based study [0.03%]
美国人群研究中全氟和多氟化合物暴露与女性生育寿命之间的关联性研究
Anhui Ning,Feng Shao,Qingzheng Yang et al.
Anhui Ning et al.
Wide exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) poses a great risk to human reproductive health. Reproductive longevity is a major factor influencing the female reproductive cycle and affects women's healthy ageing. Ho...
Rosuvastatin exposure during adulthood increases ovarian follicular atresia and reduces reproductive performance in female mice [0.03%]
成人期暴露于罗苏伐他汀增加小鼠卵泡闭锁并降低雌性生殖能力
Amanda Rebonatto Oltramari,Alice Santos Da Silva,Marina Machado Cabrera et al.
Amanda Rebonatto Oltramari et al.
Statins are widely used to manage lipid disorders and reduce cardiovascular risk in humans. Rosuvastatin, one of the most effective statins, decreases cholesterol biosynthesis and exerts pleiotropic effects. However, recent studies indicate...
Tributyl phosphate disrupts hepatic lipid metabolism via cGAS-STING signal pathway mediated inflammation [0.03%]
三丁基磷酸盐通过cGAS-STING介导的炎症扰乱肝脏脂质代谢
Liwei Yang,Zhili Ge,Xuehan Ding et al.
Liwei Yang et al.
Tributyl phosphate (TBP) can lead to abnormal hepatic lipid metabolism. Inflammation triggered by the cGAS-STING may be involved in it. Within this research, we investigated the involved mechanisms of TBP-induced lipid metabolic disorders. ...
Maternal dibutyl benzene-1,2-dicarboxylate exposure accelerates bone marrow mesenchymal stem cells senescence to induce skeletal retardation in male offspring mice [0.03%]
母体邻苯二甲酸二丁酯暴露通过加速子代骨髓间充质干细胞衰老诱导雄性小鼠骨骼生长迟滞
Yao Zhang,Kehan Wang,Jingzhu Lu et al.
Yao Zhang et al.
Dibutyl benzene-1,2-dicarboxylate (DBP), a ubiquitous plasticizer, readily crosses the placenta, posing a risk to male offspring development. Previous studies have found that maternal DBP exposure leads to multiple organ development disorde...
Enantioselective CYP inhibition by diclofop, the active metabolite of diclofop-methyl: Mechanism and relevance for human exposure [0.03%]
手性选择性细胞色素P450抑制作用：双丙醚及其代谢产物双氟磺草胺的作用机制及人类暴露的相关性研究
Maike Felipe Santos Barbetta,Giovanni Stoppa Baviera,Leandro Oka-Duarte et al.
Maike Felipe Santos Barbetta et al.
Diclofop (DF) is the main chiral metabolite of diclofop-methyl (DFM), a widely used herbicide for grass weed control. While DFM toxicity is documented, little is known about DF, despite its persistence. This study evaluated the enantioselec...
Mechanisms and management of crizotinib-induced toxicity in non-small cell lung cancer [0.03%]
非小细胞肺癌克唑替尼导致的毒副反应及其处理措施
Xiaoxiao Liu,Xinyu Tao,Mengting Cheng et al.
Xiaoxiao Liu et al.
Crizotinib, a first-in-class ALK/ROS1/MET inhibitor, has been shown to significantly improve outcomes in advanced non-small cell lung cancer (NSCLC); however, its clinical utility remains limited by multisystem toxicities. This review synth...