Sublethal Effects of Diphenyl Ether on Zebrafish Embryo: Developmental, Morphological, Cardiac and Neurotoxic Implications [0.03%]
双苯醚对斑马鱼胚胎的亚致死效应：发育、形态、心脏和神经毒性意义
Shiv Kumar,Pooja Chadha
Shiv Kumar
In 2009, the United Nations Environment Programme classified the polybrominated diphenyl ethers (PBDEs) as an emerging class of persistent organic pollutants. In the environment, less brominated diphenyl ethers can be formed by the degradat...
Modulation of SUMO1-TOP1 DNA damage repair by TOPORS following ovalbumin-induced oxidative stress in macrophages [0.03%]
TOPORS调节鸡卵白蛋白诱导的巨噬细胞氧化应激后SUMO1-TOP1DNA损伤修复作用
Xulong Cai,Qiaolan Xu,Tongjin Yin et al.
Xulong Cai et al.
Allergens, a common trigger of asthma, can lead to increased levels of reactive oxygen species (ROS) and subsequent DNA damage. However, the repair mechanism of DNA damage caused by oxidative stress in allergen-induced asthma is less known....
Influence of high-dose sodium benzoate on lipopolysaccharide-induced neurobehavioral impairment, oxido-inflammatory brain damage, and cholinergic dysfunction in rats [0.03%]
高剂量苯甲酸钠对脂多糖诱导的大鼠神经行为损伤、氧化炎症性脑损伤和胆碱能功能障碍的影响
Folake Olubukola Asejeje,Michael Abayomi Abiola,Oluwatobi Adewumi Adeyemo et al.
Folake Olubukola Asejeje et al.
Sodium benzoate (SB) is a commonly utilized food preservative in the food business. Nonetheless, apprehensions regarding its impact on the brain have garnered worldwide attention. Consequently, we examined the effect of SB on lipopolysaccha...
Investigating Zinc's role in Mitigating Blood Lead Levels' Toxicity on Gut Microbiota Diversity: NHANES 2007-2010 [0.03%]
锌在减轻血铅水平对肠道微生物群多样性毒性作用中的作用研究：基于NHANES 2007-2010数据的研究
Kathyrn R Ayres,Juan P Liuzzi,Freeman C Lewis et al.
Kathyrn R Ayres et al.
Introduction: Zinc serves as a cofactor for numerous vital processes across species. Microorganisms that make up the gut microbiome rely on these zinc-dependent mechanisms to perform essential functions, contributing to a...
Harmful Beauty - Temporal Profile of Urinary Phthalate Metabolites in Tattooed Volunteers from Slovakia [0.03%]
有害的美丽-来自斯洛伐克受纹身志愿者尿液中酞酸盐代谢物的时间分布特征
Branislav Kolena,Natalia Prochácková,Henrieta Hlisníková et al.
Branislav Kolena et al.
Tattoos are becoming increasingly popular, but tattoo inks often contain harmful chemicals such as phthalates, which are endocrine disruptors. The study aimed to biomonitoring of phthalate metabolites. Seven tattooed subjects were recruited...
Inhibition of placental 11β-HSD2 expression through cAMP/PKA signaling pathway induces intrauterine growth retardation [0.03%]
通过cAMP/PKA信号通路抑制胎盘11β-HSD2表达导致宫内生长受限
Caiyun Ge,Luting Yu,Man Fang et al.
Caiyun Ge et al.
It is known that excessive exposure to maternal glucocorticoids during fetal development can cause fetal intrauterine growth retardation (IUGR) and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays an important role in the regulati...
Multigenerational toxicity and transcriptomic changes induced by environmentally relevant concentrations of microcystin-LR and -RR in Caenorhabditis elegans [0.03%]
环咽螠暴露于环境相关浓度的微囊藻毒素-LR和-RR后的多代毒性和转录组变化
Xialian Wang,Jingyi Zhang,Zhenxiao Cao et al.
Xialian Wang et al.
Microcystin (MC) contamination in surface water is currently receiving considerable attention as a public health concern. Seasonal occurrence MCs in aquatic environment suggests their long-term impacts on ecosystem and human health, whereas...
An in vitro safety evaluation model for assessing the effects of a chemical drug on the human intestinal barrier integrity using genetically modified Caco-2 cells expressing drug-metabolizing enzymes [0.03%]
一种体外安全评估模型：使用表达药物代谢酶的基因修饰Caco-2细胞评估化学药物对人肠道屏障完整性的的影响
Lin Bai,Shuko Sakimura,Yuki Niwa et al.
Lin Bai et al.
The human intestinal cell line Caco-2 is widely used as an in vitro human intestinal barrier-integrity model for safety evaluation of xenobiotics including drugs, but the profiles of chemical-metabolizing enzymes differ between Caco-2 and t...
Vanadium - good or bad - the role of vanadium in the central nervous system disorders, potential therapeutic targets and its toxicity [0.03%]
钒利弊谈-钒在中枢神经系统紊乱中的作用、潜在治疗靶点及其毒性
Katarzyna Stachowicz
Katarzyna Stachowicz
When we see dust particles floating in the sunlit air, we do not realize that these particles also contain vanadium. Vanadium (V) is a trace element in air, soil, water, and food. In living organisms, it occurs mainly as vanadyl (cation) or...
The effect of phthalates on insulin secretion of pancreatic beta cells based on cellular studies, a systematic review [0.03%]
基于细胞实验的增塑剂对胰岛β细胞胰岛素分泌影响的系统性综述研究
Kiandokht Ghanati,Hadi Pourjafar,Parisa Shavali-Gilani et al.
Kiandokht Ghanati et al.
Diabetes is increasing worldwide. Phthalates are regularly detected in food and ecosystem environments at detectable levels. The purpose of this study was to review and summarize the effect of phthalates on insulin secretion from pancreatic...