Neurotoxicity of food colorants: Gut dysbiosis and reduced short-chain fatty acids disrupt the enteric nervous system and lead to neurological disability [0.03%]
食品着色剂的神经毒性：肠道微生态失调和短链脂肪酸缺乏会扰乱肠神经系统并导致神经功能障碍
Vajagathali Mohammed,Mariadhas Valan Arasu,Muthumareeswaran Muthuramamoorthy et al.
Vajagathali Mohammed et al.
For centuries, the practice of adding color to food has become deeply ingrained in culinary traditions, evolving into an indispensable aspect of food production today. Major food manufacturing companies extensively use colorants to enhance ...
Revolutionizing toxicity predictions of diverse chemicals to protect human health: Comparative QSAR and q-RASAR modeling [0.03%]
革新化学物质毒性预测以保护人类健康：QSAR与q-RASAR建模的比较
Shubha Das,Probir Kumar Ojha
Shubha Das
The extensive application of chemicals in the form of pesticides, cosmetics, drugs, etc., has been shown to adversely affect humans and the environment, mainly through food product residues and environmental exposure. Exposure to diverse ch...
Corrigendum to "The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways" [Toxicol. Lett. 347 (2021) 23-35] [0.03%]
硝氯酚对胆管结扎诱导的肝纤维化的改善作用通过抑制NOTCH和Wnt信号通路[毒理学快报347（2021）23-35]的勘误表
Manar M Esmail,Noha M Saeed,Haidy E Michel et al.
Manar M Esmail et al.
Published Erratum
Toxicology letters. 2025 Jun 28:410:197-198. DOI:10.1016/j.toxlet.2025.06.016 2025
Autophagy-dependent hepatocyte apoptosis mediates gilteritinib-induced hepatotoxicity [0.03%]
自噬依赖的肝细胞凋亡介导gilteritinib所致肝毒性
Yashi Cao,Zhaozeng Chen,Yiming Yin et al.
Yashi Cao et al.
Gilteritinib, a dual FLT3/AXL inhibitor, is clinically effective for relapsed/refractory FLT3-mutated acute myeloid leukemia (AML) but is limited by severe hepatotoxicity. This study investigates the molecular mechanisms underlying gilterit...
Corrigendum to "Dose-dependent effects of chlorpyrifos on liver injury, intestinal dysbiosis, and metabolic perturbations in C57BL/6J mice" [Toxicol. Lett. 407 (2025) 73-82] [0.03%]
关于“氯吡rifos剂量依赖性效应于C57BL/6J小鼠肝损伤、肠道菌群失调和代谢紊乱”的勘误[毒理学信函407（2025）73-82]
Shuilin Wei,Mengjing Wu,Quanzhi Qin et al.
Shuilin Wei et al.
Published Erratum
Toxicology letters. 2025 Jun 26:410:188. DOI:10.1016/j.toxlet.2025.06.017 2025
Arsenic enhances endoplasmic reticulum stress via YTHDC1/AKR1C3 aix to promote the malignant transformation of human urothelial cells [0.03%]
砷通过YTHDC1/AKR1C3轴增强内质网应激以促进人类尿路上皮细胞恶性转化
Chenglin Chen,Meiting Tong,Yuanyuan Chang et al.
Chenglin Chen et al.
Arsenic, a well-established carcinogen, is strongly associated with the development of multiple malignancies, including bladder, skin, and lung cancers. Epidemiological studies have revealed that elevated arsenic concentrations in water sou...
circ_0000554 promotes macrophage M2 polarization mediated by glycolytic reprogramming and aggravates COPD injury [0.03%]
circ_0000554通过糖酵解重编程促进巨噬细胞M2极化并加重慢性阻塞性肺疾病损伤
Yamei Song,SiQin Han,Linlin Liu et al.
Yamei Song et al.
Environmental pollution, such as fine particulate matter (PM2.5), poses a serious threat to people's health. PM2.5 can induce lung injury, and the damage to chronic obstructive pulmonary disease (COPD) is more intense. Nevertheless, the reg...
Prenatal microcystin-LR exposure alters pancreatic proteome and impairs insulin secretion in offspring mice [0.03%]
孕前微囊藻毒素-LR暴露改变小鼠后代胰腺蛋白质组并影响其胰岛素分泌
Yu Chen,Guofang Chen,Yijiao Xu et al.
Yu Chen et al.
This study examines the toxic effects of microcystin-LR (MC-LR), a cyanobacterial toxin, on glucose metabolism in the pancreatic β cells of offspring following maternal exposure in mice. Female mice were exposed to varying concentrations o...
Occupational exposure to amorphous silica nanoparticles alters lung function and metabolomic features [0.03%]
无定形二氧化硅纳米颗粒的职业暴露会改变肺功能和代谢特征
Xuemin Shi,Chen Liang,LinLin Wang et al.
Xuemin Shi et al.
Amorphous silica nanoparticles (SiNPs) are widely produced and used nanomaterials. Although studies have extensively documented SiNPs-induced pulmonary injuries in animal models, the adverse effects on humans remain unclear due to a lack of...
Enhancement of cigarette smoke extract-induced goblet cell metaplasia and hyperplasia exerted through IL-13 receptor α1 expression [0.03%]
通过IL-13受体α1诱导支气管粘液细胞增生和转化的增强
Akina Mori,Risa Matsumoto,Sakuya Ichikawa et al.
Akina Mori et al.
Chronic airway inflammation, such as that occurring in chronic obstructive pulmonary disease, induces goblet cell metaplasia and hyperplasia (GCMH) and leads to hyperproduction of mucus and thickening of airway walls, restricting airflow. C...