The interaction between DNA methylation and single-nucleotide polymorphism in regulating the mRNA expression of CYP1A1, GSTP1 and GSTM1 in population [0.03%]
DNA 甲基化与单核苷酸多态性在人群种系中调节 CYP1A1、GSTP1 和 GSTM1 的 mRNA 表达的相互作用
Aixiang Liu,Yuxin Shi,Xin Li et al.
Aixiang Liu et al.
While polycyclic aromatic hydrocarbon (PAH) exposure is widely known to influence the expression of metabolic enzyme genes, the roles of DNA methylation and single-nucleotide polymorphisms (SNPs) remain unclear. This study aimed to investig...
Monitoring air pollution effects on children (MAPEC) living near cement factories: The MAPEC_Gubbio Study [0.03%]
监测水泥厂附近儿童空气污染的影响：MAPEC_古比奥研究
Edoardo Franceschini,Tommaso Rondini,Mattia Acito et al.
Edoardo Franceschini et al.
The present study examined the association between airborne pollutants and early biological effects in children, a group particularly vulnerable to immediate and long-term effects, underscoring the importance of early detection. Researchers...
Is maternal smoking during pregnancy associated with childhood brain tumors? A systematic literature review [0.03%]
孕期母亲吸烟与儿童脑肿瘤有关吗？系统文献综述
Ulla Autio,Heidi Sahlman,Miia Tiihonen et al.
Ulla Autio et al.
With a global prevalence of 1.7%, smoking during pregnancy commonly still occurs in many countries. Tobacco smoke contains several harmful and carcinogenic compounds which can cross the placental barrier and cause adverse effects on materna...
Surface-water estradiol-benzo[a]pyrene mixtures: Transcriptomics in a PC12 neuronal differentiation model nominate an E2F1-PTPRO axis as a candidate mechanistic biomarker [0.03%]
水环境中的雌二醇与苯并(a)芘混合物：基于PC12神经分化模型的转录组学研究提名E2F1-PTPRO轴为潜在机制生物标志物
Caiyun Sun,Peng Wang,Yu Xia et al.
Caiyun Sun et al.
Background: Mixtures of estradiol (E2) and benzo[a]pyrene (BaP) occur in surface waters. Seasonal sampling at Longxing Village (Jilin, China) showed total PAHs 1.07-3.14 mg L⁻¹ (BaP 3.0 ×10⁻²-1.3 ×10⁻¹ mg L⁻¹) a...
An in vitro model of bleomycin-induced epithelial injury using stem cell-derived alveolar type 2 epithelial cells [0.03%]
利用干细胞衍生的II型肺泡上皮细胞建立博莱霉素诱导的上皮损伤体外模型
Yubin Han,Ha Ryong Kim,Jun Woo Kim et al.
Yubin Han et al.
Human alveoli constitute most of the lung parenchyma and play a pivotal role in respiratory diseases. Traditional alveolar type 2 epithelial cells, such as A549 and H441, have been widely used to study pulmonary toxicity mechanisms. However...
Tripchlorolide-induced reversible impairment of male fertility and the involvement of PI3K/Akt/mTOR signaling [0.03%]
三氯化物诱导的可逆性雄性不育及PI3K/Akt/mTOR信号途径的参与
Lele Zhou,Lingbin Chen,Cailin Zheng et al.
Lele Zhou et al.
Tripchlorolide, a low-toxicity derivative of the natural product triptolide, exhibits significant therapeutic potential for inflammatory and autoimmune diseases; however, its profile of male reproductive toxicity remains a major concern for...
Advances in aluminum oxide nanoparticles-induced neurotoxicity: CNS translocation, phenotypic outcomes, and mechanistic insights [0.03%]
先进氧化铝纳米粒子诱导的神经毒性进展：中枢神经系统转运、表型结果和机制见解
Lei Yu,Mohammad Nasiruddin Rana,Changjian Quan et al.
Lei Yu et al.
Aluminum oxide nanoparticles (Al2O3 NPs) exhibit remarkable physicochemical properties, making them essential for many applications such as high-temperature refractory materials, catalysis, biomedical uses, and environmental remediation. Th...
Artificial intelligence revolution in toxicology: Clinical precision, global equity, and the 2030 roadmap [0.03%]
毒理学领域的人工智能革命：临床精准性、全球公平性和2030年路线图
Jose L Domingo
Jose L Domingo
Artificial intelligence (AI) is transforming toxicology by enabling faster, more accurate, and more equitable approaches to diagnosis, treatment, research, and education. This review synthesizes recent advances in AI applications across cli...
Thallium: An Overview of Its Distribution in the Environment and Its Cellular and Molecular Toxicity [0.03%]
铊：其环境分布及其细胞和分子毒性的综述
Alexandre Varão Moura,Lucas Aleixo Leal Pedroza,José Domingos Santo da Silva et al.
Alexandre Varão Moura et al.
Thallium (Tl), a rare but highly toxic trace metal, poses significant environmental and health risks due to its increasing industrial applications and potential for contamination. This narrative review focuses on Tl's presence in soil and i...
Hepatobiliary Clearance of a Long and Thick Carbon Nanotube following Pulmonary Exposure in Mice [0.03%]
小鼠经肺暴露长而厚的碳纳米管后的肝胆清除率
Mathilde Sundberg,Trine Berthing,Pernille Høgh Danielsen et al.
Mathilde Sundberg et al.
Long and thick carbon nanotubes (CNTs), such as Mitsui-7, can translocate from the lungs to secondary organs, including the liver, following pulmonary exposure. Although Mitsui-7 CNT is biopersistent, previous studies have suggested clearan...