A stimulating effect induced by Bisphenol A bis (diphenylphosphate) in HepG2 cells via vascular endothelial growth factor (VEGF)/VEGF receptor axis [0.03%]
双酚A双(二苯基磷酸酯)通过血管内皮生长因子/血管内皮生长因子受体轴诱导肝癌HepG2细胞增值作用的研究
Jing An,Yuting Yi,Na Li et al.
Jing An et al.
With the widespread distribution and increasing detection levels of Bisphenol A bis (diphenylphosphate) (BDP) in environment, toxicity risk assessment on BDP has become indispensable issue. So far, available toxicological information about ...
The mitochondrial fission-mitophagy axis drives neuronal S-phase arrest and hippocampal damage in co-exposure to polystyrene nanoplastics and lead [0.03%]
聚苯乙烯纳米塑料和铅共暴露驱动线粒体分裂-自噬轴，诱导神经元细胞周期停滞和海马损伤
Qian Li,Yingwei Zhang,Yanjing Hu et al.
Qian Li et al.
Smaller polystyrene nanoplastics (PS-NPs) can act as vectors for co-existing environmental heavy metals like lead (Pb). The complex neurological health risks posed by these co-exposures are concerning, but their combined neurotoxicity mecha...
Snake venom-induced tissue damage as a paradigm of redox imbalance, ferroptosis, and inflammaging [0.03%]
以氧化损伤失衡、铁死亡和炎症衰老为特征的蛇毒诱导性组织损伤
Ritu Dahiya,Ajay Pal Singh,Aruna Rawat
Ritu Dahiya
Snakebite envenomation remains a major cause of illness globally, resulting in complex local and systemic toxic effects. Although the biochemical functions of individual snake venom components have been extensively studied, the cellular mec...
Influence of hepatic steatosis on antiseizure drug metabolism: in vitro evidence from differentiated HepaRG cells [0.03%]
肝脂肪变性对抗癫痫药物代谢的影响：来自分化HepaRG细胞的体外证据
Valentin Plissonneau,Thomas Gicquel,Emma-Rose Legrand Brault et al.
Valentin Plissonneau et al.
Background: Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) could impair hepatic drug metabolism by altering cytochrome P450 and conjugating enzyme activities, potentially affecting the pharma...
Targeting PCSK9 suppresses NF-κB-mediated M1 polarization in alveolar macrophages and lung injury induced by low-dose systemic PM2.5 exposure [0.03%]
PCSK9靶向抑制NF-κB介导的低剂量PM2.5系统暴露诱导的肺泡巨噬细胞M1极化和肺损伤
Chenxi Wang,Weichao Zhang,Yanjun Liu et al.
Chenxi Wang et al.
Background: Fine particulate matter (PM2.5) exposure is a major environmental risk factor for pulmonary inflammation and injury, in which alveolar macrophages (AMs) play a central role. Proprotein convertase subtilisin/ke...
From cellular toxicity and inflammation to human safety: An integrated in vitro-in silico assessment of 5-hydroxymethylfurfural (HMF) [0.03%]
从细胞毒性和炎症到人类安全：5-羟甲基糠醛(HMF)的体内外整合评估
Denise Carreiro Faustino,Larissa de Oliveira Santos,Beatriz de Araújo Carneiro Feitosa et al.
Denise Carreiro Faustino et al.
5-Hydroxymethylfurfural (HMF) is a heat-induced food contaminant whose toxicological relevance remains under debate. This study integrates in vitro assays, in silico modelling, and probabilistic exposure assessment to characterize the risk ...
Bisphenol S and High-Fat Diet Drive Structural and Inflammatory Remodeling of the Colon in C57Bl/6 Male Mice [0.03%]
双酚S和高脂饮食驱动C57Bl/6雄性小鼠结肠结构和炎症重塑
Beatriz Gouvêa de Luca,Beatriz Alexandre-Santos,Kauet de Matos Gama E Souza et al.
Beatriz Gouvêa de Luca et al.
Bisphenol S (BPS) is an emerging environmental contaminant with endocrine-disrupting properties capable of triggering early gastrointestinal alterations linked to intestinal remodeling. This study investigated the effects of BPS and a high-...
Double-walled carbon nanotubes promote ASC speck formation and inflammasome activation in vascular endothelial cells [0.03%]
双壁碳纳米管促进血管内皮细胞中ASC斑点形成和炎性小体活化
Ryoya Takizawa,Gaku Ichihara,Yuka Suzuki et al.
Ryoya Takizawa et al.
Carbon nanotubes (CNTs) are important industrial nanomaterials, yet their manufacture presents potential risks for respiratory exposure among workers. CNTs have a high aspect ratio, which raises concerns that they may cause toxicity similar...
Genotoxicity assessment of nylon and polyethylene microparticles in Caco‑2 cells [0.03%]
尼龙和聚乙烯微塑料的基因毒性评估——基于Caco-2细胞体系的研究
Marjo Huovinen,Essi Järvelä,Mikko Herrala et al.
Marjo Huovinen et al.
Microplastics (size < 5mm) are ubiquitous in the environment, but their consequences on human health are still largely unknown. Nylon and polyethylene (PE) are widely used polymers in various applications, and although human exposure to the...
Deoxynivalenol-induced hepatic and renal injury via pyroptosis under heat stress conditions [0.03%]
热应激下脱氧雪腐镰刀菌烯醇诱导肝肾(py)细胞死亡导致肝肾损伤
Jingdi Zhang,Amna Rafique,Jie Liu et al.
Jingdi Zhang et al.
Elevated temperatures impose physiological stress on mammals. Meanwhile, high heat and humidity boost mold growth in feed and bedding, potentially increasing deoxynivalenol (DON) contamination. Heat stress and DON both cause hepatorenal dam...