Imidacloprid and its major metabolites blocks the alpha subunit of the human hERG (KV11.1) channel: Evidence from in-silico and fluorescence polarization studies [0.03%]
基于计算机和荧光偏振研究的imidacloprid及其主要代谢产物通过阻断人源hERG(KV11.1)通道α亚基发挥作用：来自计算机模拟和平行荧光实验的证据
Vankadoth Umakanth Naik,Ajay Godwin Potnuri,Swati Sharma et al.
Vankadoth Umakanth Naik et al.
Neonicotinoids are high affinity agonists of insect Nicotinic Acetyl Choline Receptors (nAChRs) resulting in insect paralysis and death. Although they are assumed to have relatively low affinity towards mammalian and other non-insect nAChRs...
In silico Toxicity assessment and trace level quantification of potential genotoxic impurities in Imipramine hydrochloride [0.03%]
盐酸伊米普拉明杂质的遗传毒性评估及痕量分析
Vighnesh Pradeep Nalawade,Ravindra Kulkarni,Faiz Hussain Sayyed et al.
Vighnesh Pradeep Nalawade et al.
Since the adoption of the ICH M7 guidelines in 2014, pharmaceutical industries have been mandated to screen all reagents and chemicals used in drug synthesis for genotoxicity. Genotoxic impurities (GTIs) have the potential to induce mutatio...
Gentamicin aggravates renal injury by affecting mitochondrial dynamics, altering renal transporters expression, and exacerbating apoptosis [0.03%]
新霉素通过影响线粒体动力学、改变肾转运蛋白表达和加剧细胞凋亡加重肾损伤
Mingkang Zhang,Yan Zhou,Xiujuan Wang et al.
Mingkang Zhang et al.
Drug-induced nephrotoxicity has developed as a prevalent trigger in patients with hospital-acquired AKI. Gentamicin, a broad-spectrum bactericidal aminoglycoside antibiotic, is used clinically in synergy with other antibiotics. However, the...
Deciphering the influence of heavy metals on adverse cardiovascular events using machine learning [0.03%]
基于机器学习解析重金属与心血管不良事件的关联性
Guanmou Li,Tong Zhang,Kunyang He et al.
Guanmou Li et al.
This study investigates the association between chronic heavy metal exposure (lead [Pb], arsenic [As], cadmium [Cd]) and major adverse cardiovascular events (MACE) using data from 15,342 participants in the 2003-2018 NHANES survey. Utilizin...
Sara Diogo Gonçalves,Mariana Rodrigues,Mariana Avidos et al.
Sara Diogo Gonçalves et al.
Animal experimentation has historically supported biomedical and toxicological research; however, its limitations in accurately predicting human responses, combined with ethical and regulatory pressures, have driven the development of alter...
Nitric oxide plays a role in anxiety- and depression-like behaviors induced by sodium metabisulfite intake in rats [0.03%]
亚硝酸盐诱发大鼠焦虑抑郁样行为与一氧化氮有关研究
Mustafa Munzuroğlu,Çiğdem Gökçek Saraç,Ayşegül Gemici Sinen et al.
Mustafa Munzuroğlu et al.
This study was carried out to investigate the effects of sulfite toxicity anxiety- and depression-like behaviors and elucidate the involvement of nitric oxide (NO) in this interaction. One hundred male Wistar rats were divided into four gro...
KCNQ1OT1/miR-140-5p/PTP4A3 axis is involved in endosulfan-induced vascular endothelial cell migration linking to atherosclerosis [0.03%]
KCNQ1OT1/miR-140-5p/PTP4A3轴参与毒杀芬诱导的血管内皮细胞迁移与动脉粥样硬化有关
Boxiang Zhang,Qing Li,Yanyuan Lu et al.
Boxiang Zhang et al.
Endosulfan, an organochlorine pesticide, is implicated in human cardiovascular diseases. Protein-tyrosine phosphatase 4A3 (PTP4A3) has been identified to play a critical role in endothelial cell migration when exposure to endosulfan. In the...
Protective effect of glucocorticoid receptor against lung inflammation induced by nicotine-derived nitrosamine ketone is mediated by suppression of the ROS-mediated cyclooxygenase-2/prostaglandin E2 pathway in human distal lung epithelial A549 cells [0.03%]
糖皮质激素受体通过抑制ROS介导的环氧合酶-2/前列腺素E2途径对抗尼古丁衍生亚硝胺酮诱导的A549细胞肺部炎症的作用研究
MyeongKuk Shim,Wonchung Lim
MyeongKuk Shim
Cigarette smoking is a significant risk factor for lung cancer. The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway is a well-established key player in inflammation and tumorigenesis, both of which are linked to cigarette smoking. ...
The role of endoplasmic reticulum stress in Atrazine-induced hepatic lipid accumulation [0.03%]
阿特拉津诱导的肝脂质累积与内质网压力的关系研究
Honghao Qian,Shuping Ren,Haotang Zhao et al.
Honghao Qian et al.
Atrazine (ATR) is an extensively applied triazine herbicide which belongs to the persistent environmental endocrine disruptors. ATR is capable of penetrating the body and disrupting lipid metabolism, but its underlying mechanism is still un...
Nano-Assault on the Heart: Molecular Pathways of Lead Oxide Nanoparticle Cardiotoxicity [0.03%]
纳米心脏攻击：铅氧化物纳米粒子心血管毒性的分子途径
Oksana Gerzen,Salavat Nabiev,Alyona Tzybina et al.
Oksana Gerzen et al.
Lead is closely associated with increased cardiovascular risk. We investigated the molecular mechanisms underlying the impact of lead nanoparticle exposure (PbNP) on the myocardium in different heart chambers, comparing the effects of PbNP ...