Erythrotoxicity of iron-doped cerium oxide nanoparticles is mediated by eryptosis [0.03%]
铁掺杂的二氧化铈纳米粒子的红细胞毒性通过eryptosis介导产生
Volodymyr Prokopiuk,Mykyta Lupan,Ganna Grygorova et al.
Volodymyr Prokopiuk et al.
Iron doping has been reported to significantly modify the properties of metal oxide nanoparticles (NPs), including their interaction with cells and therefore toxicity. The present study explores the ability of Fe³ ⁺-doped CeO2 NPs with th...
A generic physiologically based kinetic model for the domestic cat (Felis catus): Model characterisation, validation and reporting using the OECD reporting template [0.03%]
一种用于家猫（Felis catus）的生理基元动力学模型：使用经合组织报告模板进行的模型特征描述、验证和申报研究
Fotios Spyropoulos,Matteo Riccardo Di Nicola,Jose V Tarazona et al.
Fotios Spyropoulos et al.
Domestic cats (Felis catus) are among the most popular pets in the world, with the global domestic cat population generally estimated to exceed 600 million and potentially approach 1 billion when feral populations are included. As hypercarn...
Multi-Platform In Silico Assessment of Selected A-Series (Novichok) Nerve Agents: Physicochemical, Toxicological, and Mechanistic Insights [0.03%]
关于A系列（诺维乔克）类神经剂的多平台计算机评估：物理化学、毒理学和机制分析
Ioanna Kanavou,Sotiria Anastasiou,Michail Chalaris
Ioanna Kanavou
A multi-platform in silico framework was developed to characterize five selected A-series (Novichok) nerve agents-A-230, A-232, and A-234 (each evaluated using Ellison- and Mirzayanov-type structural representations) [1,2] together with A-2...
Mixed exposure to brominated flame retardants adversely affects vaccine-induced antibody titers: Risk prioritization and benchmark dose modeling [0.03%]
溴化阻燃剂混合暴露会影响疫苗诱导的抗体滴度：风险排序与基准剂量模型
Zihui Zhao,Chi Zhang,Xueyu Chen et al.
Zihui Zhao et al.
The association between brominated flame retardant (BFRs) exposure and measles, mumps, and rubella vaccine (MMR) antibody responses was investigated using the National Health and Nutrition Examination Survey (2003-2004). Using multivariate ...
Toxicological potential of nanomaterials by concentration-dependent transcriptomics of human cells [0.03%]
浓度依赖性转录组学探讨纳米材料对人体细胞毒理作用的潜力
Wendi Fang,Mingming Tian,Xiao Gou et al.
Wendi Fang et al.
Biological pathways altered by nanomaterials can be used to predict potential hazards to humans and wildlife. However, the impacts of particle size, charge, and chemical composition of nanomaterials on biological pathways in the cellular sy...
Tributyltin exposure disrupts intestinal barrier and enteric nervous system in the ileum of Wistar rats [0.03%]
三丁基锡暴露破坏Wistar大鼠回肠肠道屏障和肠神经系统
Gabriela Pustiglione Marinsek,Isabelly Cristina Correia Dos Santos de Oliveira,Manuela Agulló Tagliamento et al.
Gabriela Pustiglione Marinsek et al.
Tributyltin (TBT) is a lipophilic compound known to damage biological membranes and is associated with neurotoxic and inflammatory effects. This study evaluated the impact of TBT (20 ng/g and 600 ng/g) on the gastrointestinal tract (GIT) ba...
Tacrolimus-Accelerated Renal Interstitial Injury in Subtotal Nephrectomized Rats and Its Pharmacological Modulation by Everolimus [0.03%]
他克莫司致残肾大鼠肾脏间质损伤及依维莫司对其药理学干预作用研究
Yuko Nakayama,Sachiko Kamikawa,Satohiro Masuda
Yuko Nakayama
Tacrolimus, a calcineurin inhibitor widely used in clinical practice, is associated with chronic nephrotoxicity, particularly under conditions of reduced renal reserve. However, experimental models that efficiently reproduce tacrolimus-acce...
Benzothiazole and 2-mercaptobenzothiazole impair reproduction by disrupting sperm function in Caenorhabditis elegans [0.03%]
苯并噻唑和2-(1H)-苯并噻唑硫醇通过干扰精子功能而损害小鼠繁殖能力
Qing Zhao,Zhenxiao Cao,Jingyi Zhang et al.
Qing Zhao et al.
Benzothiazoles (BTs), derived primarily from tire wear particles, are ubiquitous contaminants that pose significant environmental hazards and health risks. This study evaluated the effects of benzothiazole (BTH) and 2-mercaptobenzothiazole ...
Systemic inflammation moderate the association between urinary polycyclic aromatic hydrocarbon metabolites and hypertensive adults [0.03%]
尿多环芳烃代谢物与高血压成人之间的关系受系统性炎症的影响
Jing Liu,Ziwei Zhou,Xu Zhu et al.
Jing Liu et al.
Background: This study aims to investigate the mediation effects of the systemic inflammation on the association between urinary polycyclic aromatic hydrocarbons (PAHs) metabolites and hypertension in general US populatio...
Corrigendum to "Acanthoic acid protectsagainst ethanol-induced liver injury: Possible role of AMPK activation and IRAK4 inhibition" [Toxicol. Lett. 281 (2017) 127-138] [0.03%]
“灯台叶酸保护酒精性肝损伤：AMPK激活和IRAK4抑制的可能作用”的勘误启事
You-Li Yao,Xin Han,Jian Song et al.
You-Li Yao et al.
Published Erratum
Toxicology letters. 2026 Apr 18:111897. DOI:10.1016/j.toxlet.2026.111897 2026