CYCLIN-DEPENDENT KINASE INHIBITOR ABEMACICLIB-INDUCED CUTANEOUS RESPONSES MEDIATED BY INFLAMMATION [0.03%]
ABemaciclib诱导的皮肤反应由炎症介导
Tuğçe Boran,Özce Pala Çamlı,Mahmoud Abudayyak et al.
Tuğçe Boran et al.
Abemaciclib is a cyclin-dependent kinase (CDK) enzyme inhibitor approved by the FDA for advanced and metastatic breast cancer therapy. Abemaciclib has caused someadverse reactions, such as dermatitis and skin reactions; however, the underly...
LncRNA SNHG15 Sponges miR-3143/FOXO3 to Regulate Autophagy in Ovarian Dysfunction Induced by Benzene Exposure [0.03%]
长链非编码RNA SNHG15通过海绵作用吸附miR-3143/FOXO3调节苯致卵巢功能障碍中自噬作用
Zhongming Ye,Qihao Huang,Haipeng Wu et al.
Zhongming Ye et al.
Benzene, a recognized carcinogen, is utilized in synthesizing various chemicals. Epidemiological studies have established a positive correlation between benzene exposure and increased incidences of abnormal menstruation and dysmenorrhea. Th...
Human in vitro metabolism of an environmental mixture of polycyclic aromatic hydrocarbons (PAH) found at the Portland Harbor Superfund Site [0.03%]
人对环境中多环芳香烃(PAH)的体外代谢作用——波特兰港区超级基金网站案例研究
Kari A Gaither,Kimberly Tyrrell,Whitney Garcia et al.
Kari A Gaither et al.
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that pose health risks to humans. Toxicity testing approaches of PAHs have evolved from traditional rodent models to New Approach Methodologies (NAMs), such a...
Cluster-based read-across of ToxCast data identifies buprofezin as a partial PPARγ agonist with obesogenic potential [0.03%]
基于聚类的ToxCast数据读跨分析识别出具有致肥胖潜能的半激动剂布普罗辛zin应在最后，前面的部分是中文标题翻译结果：基于聚类的ToxCast数据读跨分析识别出具有致肥胖潜能的PPARγ半激动剂布普罗辛
Seokyoung Hwang,Soyeon Oh,Seungchan An et al.
Seokyoung Hwang et al.
The identification of environmental obesogens has become increasingly urgent amid rising rates of metabolic disorders linked to chemical exposures. Here, we employed a cluster-based read-across framework that integrates structural descripto...
Dose-Dependent Hepatotoxicity in Norway Rat: Investigating the Effects of Methadone and Morphine on Liver Gene Expression and Function [0.03%]
剂量依赖性肝毒性研究：美沙酮和吗啡对基因表达和功能的影响
Hamid Norioun,Saeedeh Ghiasvand
Hamid Norioun
Methadone and morphine are two widely prescribed opioids for pain management and opioid substitution therapy. While both are pharmacologically effective, their long-term use may induce hepatotoxic effects. This study aimed to evaluate the h...
Associations of semen essential/non-essential elements with the risk of male infertility: a systematic review and meta-analysis [0.03%]
微量元素和非微量元素与男性不育风险的关系：系统评价和meta分析
Jianfeng Chen,Wenwen Tan,Zhilian Chen et al.
Jianfeng Chen et al.
Background: Defective sperm function is the leading cause of male infertility, and epidemiological studies have revealed that various trace elements are linked to declining semen quality. However, differences in study qua...
Cytokine Profile and Early Immune Response to SARS-CoV-2 in Occupationally Lead-Exposed Individuals: A Cross-Sectional Study [0.03%]
职业铅暴露者SARS-CoV-2细胞因子谱和早期免疫反应：一项横断面研究
Marta Jeziorska,Sławomir Kasperczyk,Michał Słota et al.
Marta Jeziorska et al.
Background: The adaptive immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by the production of various antibodies, with immunoglobulin M (IgM) being the initial isotype synt...
Zinc and Titanium Nanoparticles exposure intensifies the risk of skin issues by elevating cytokine gene expression despite following current international safety protocols [0.03%]
锌和钛纳米颗粒的暴露会加剧皮肤问题的风险，即使遵循当前的国际安全协议也会通过提高细胞因子基因表达来增加风险
Vahid Babaei,Azadeh Ashtarinezhad,Maryam Torshabi et al.
Vahid Babaei et al.
Objectives: The growing use of nanomaterials in daily life has raised concerns about their biological effects and potential toxicity. This study examines the impact of Zinc oxide (ZnO) and Titanium dioxide (TiO₂) nanopar...
Cuproptosis is involved in small intestinal toxicity in the paraffins during pregnancy [0.03%]
杯状细胞程序性死亡参与母体妊娠期间烃类化合物引起的小肠毒性作用机制研究
Juan Tang,Zemin Xu,Mengna Jiang et al.
Juan Tang et al.
Short-chain chlorinated paraffins (SCCPs) is generally regarded as an emerging persistent organic pollutant. So far, small intestine injury in the progeny of adult mice exposed to SCCPs during pregnancy has not yet been the subject of any r...
Exploring the impact of lysis conditions on the alkaline standard and Fpg-modified in vivo comet assay [0.03%]
探讨裂解条件对碱性标准和Fpg修饰的体内彗星试验的影响
M Collia,E Saenz-Martinez,A Vettorazzi et al.
M Collia et al.
The comet assay is a method used to detect DNA lesions. The protocol involves cell lysis and electrophoresis of the DNA once the cells are embedded in agarose. In this study, we investigated how lysis duration and pH affect Wistar rat tissu...