Comparing the performance of solution-based decontaminants following exposure to toxic industrial chemicals on human skin [0.03%]
毒性工业化学品在人体皮肤上暴露后溶液去污剂的性能比较研究
Sharyn Gaskin,Ruchira Ranaweera,Leigh Thredgold et al.
Sharyn Gaskin et al.
The extensive use of industrial chemicals increases the likelihood of accidental or deliberate environmental release, potentially occurring in occupational, public, or military settings, with skin contact being an important route of exposur...
Permethrin in companion animals: mechanistic neurotoxicity, dermal pharmacokinetics, and secondary exposure pathways [0.03%]
伴生动物中的苯氧威：机制性神经毒性、皮肤药代动力学和二次暴露路径
Domenico Britti,Fabio Castagna,Roberto Bava
Domenico Britti
Permethrin remains one of the most widely used pyrethroids in companion animal ectoparasite control, yet its toxicological profile reflects a complex interplay between mechanism of action, dermal delivery, formulation behaviour and secondar...
Acetyl-CoA synthetase 2 nuclear translocation impediment contributes to nickel induced histone hypoacetylation and neurite outgrowth impairment [0.03%]
乙酰辅酶a合成酶2核转位障碍参与镍致组蛋白低乙酰化及神经突起生长障碍
Chao Zhou,Jianbo Zhang,Wenjuan Zhang et al.
Chao Zhou et al.
Histone hypoacetylation is a well-documented phenomenon associated with nickel (Ni) induced toxic effects, including neurotoxicity. However, the mechanism for histone hypoacetylation in Ni exposure remains ambiguous. Recently, acetyl-CoA av...
A full thickness in vitro model of human skin for the penetration of highly toxic VX and the evaluation of different decontaminants [0.03%]
Gabriele Horn,Amelie Schwab,Franz Worek et al.
Gabriele Horn et al.
The dermal exposure to persistent nerve agents such as VX may lead to skin penetration and uptake in the circulatory system. So far, the efficacy of decontamination lotions to remove VX from the skin has been investigated in vitro using met...
Mitigating Algorithmic Bias in AI-Powered Toxicology: Frameworks for Explainable and Equitable Predictions in Human Health and Environmental Safety [0.03%]
人工智能毒理学中的算法偏见缓解：解释性和公平性预测的人类健康和环境安全框架
Olawale M Ajisafe,Lydia Adeola Ogebule,Eghosasere Egbon et al.
Olawale M Ajisafe et al.
The rapid integration of artificial intelligence (AI) and machine learning into predictive toxicology has transformed chemical hazard identification, toxicity endpoint forecasting, and risk assessment for pharmaceuticals, environmental poll...
Plasma protein binding, metabolic stability, oral bioavailability and disposition kinetics of bisphenol AP in rats [0.03%]
双酚AP的血浆蛋白结合力、代谢稳定性、口服生物利用度及大鼠药动学参数的研究
Arunima Sharma,C Yahavi,Manisha Bhateria et al.
Arunima Sharma et al.
Bisphenol A (BPA) is a recognised endocrine disruptor resulting in regulatory restrictions and a search for safer alternatives. Bisphenol AP (BPAP), introduced as a BPA substitute, has shown endocrine-disrupting potential and is linked to g...
HECTD1 promotes pulmonary fibrosis by targeting EMT and subsequent fibroblasts activation [0.03%]
HECTD1通过促进上皮间质转化及随后的成纤维细胞活化来促进肺纤维化
Zewei Zhou,Teng Geng,Yiwei Hu et al.
Zewei Zhou et al.
Epithelial-mesenchymal transition (EMT) is characterized by enhanced fibroblast activation and excessive extracellular matrix deposition, ultimately leading to fibrosis. However, its specific role in silicosis and the underlying mechanisms ...
Corrigendum to "Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction" [Toxicol. Lett. 387 (2023) 1-13] [0.03%]
“巴瓦丁通过靶向Wnt/β-catenin/DRP1信号通路介导的线粒体功能障碍诱导肝损伤和细胞凋亡”的勘误表 [Toxicol. Lett. 387 (2023) 1-13]
Ying Yang,Wei Zhou,Yihao Wang et al.
Ying Yang et al.
Published Erratum
Toxicology letters. 2026 May 19:111920. DOI:10.1016/j.toxlet.2026.111920 2026
C Fortmann,T Goeen,N Held et al.
C Fortmann et al.
Metal release after implantation of medical metal implants can induce serious symptoms of hypersensitivity. A variety of immunologic reactions to metal particles has been demonstrated by a number of studies. To analyze the effect of metal a...
Mechanistic Biomarkers in Genotoxicity Testing: A Systematic Mapping Review of Their Integration with Apical Endpoints [0.03%]
遗传毒性试验中的机制生物标志物与其顶端终点整合的系统评价研究
Nathalia Stephanie Oliveira Nascimento,Adriana Oliveira Costa,Barbara Marra Rebuiti et al.
Nathalia Stephanie Oliveira Nascimento et al.
Genetic toxicology plays a central role in regulatory safety assessment but remains largely dependent on a standardized battery of established genotoxicity assays. Increasing attention has been directed toward the integration of mechanistic...