A Core Physiologically Based Toxicokinetic (PBTK) Model for Exposure Assessment of Multiple Environmental Phenols [0.03%]
环境酚类物质暴露评估核心生理基于毒性动力学(PBTK)模型
Jeong Weon Choi,Seungho Lee,Jangwoo Lee et al.
Jeong Weon Choi et al.
Environmental phenols are widely used in consumer products and are of increasing concern due to their potential endocrine-disrupting effects. Physiologically based toxicokinetic (PBTK) models offer a powerful tool for estimating human expos...
Emanuela Corsini,Aristidis Tsatsakis
Emanuela Corsini
Bisphenol A exposure promotes proliferation and invasion capabilities of bladder cancer cells: Insights from gene expression and pathway analysis [0.03%]
双酚A暴露通过基因表达和通路分析促进膀胱癌细胞增殖和侵袭能力
Bo Cong,He Liu,Minghui Sun et al.
Bo Cong et al.
Bisphenol A (BPA), a synthetic organic compound widely used in plastic products, toys, water pipes, and flame retardants, has been linked to the onset and progression of various cancers. This study explores the association between BPA and b...
ROLE OF PHTHALATES IN BREAST CANCER INITIATION, PROGRESSION AND DRUG RERSISTANCE: a scoping review and recommendations [0.03%]
邻苯二甲酸盐在乳腺癌发生、发展及药物抵抗中的作用：综述与建议
L Benoit,C Tomkiewicz,S Bortoli et al.
L Benoit et al.
Phthalates are endocrine-disrupting chemicals (EDCs) with implications in breast cancer (BC). This review synthesizes epidemiological and experimental data to evaluate the role of phthalates in BC initiation, progression, and therapeutic re...
Mouse Model of Prenatal Valproic Acid Exposure: Effects on Cortical Morphogenesis and Behavioral Outcomes Across Environmental Conditions [0.03%]
孕期丙戊酸盐暴露的小鼠模型：不同环境条件下对皮层形态发生和行为结果的影响
Mizuki Tanizaki,Takuma Matsui,Rei Sugiyama et al.
Mizuki Tanizaki et al.
Autism spectrum disorder (ASD) is a developmental disability characterized by impaired social communication and repetitive behaviors, and environmental and genetic factors are involved in its onset. The use of the antiepileptic drug valproi...
Clozapine-associated perturbation of arachidonic acid metabolism: A future direction for clozapine-induced cardiotoxicity [0.03%]
氯氮平诱导的心脏毒性未来研究方向：氯氮平引起的花生四烯酸代谢紊乱
Ellen Kingston,Kathryn Burns,Malcolm Tingle
Ellen Kingston
Clozapine is an effective antipsychotic medication utilised for treatment-resistant schizophrenia. However, clinical use of clozapine is limited due to the risk of cardiotoxicities, including clozapine-induced myocarditis. Oxidation of cloz...
Characterization of formaldehyde-induced hepatotoxicity based on proteometabolomic analysis [0.03%]
基于蛋白质与代谢组分析的甲醛致肝损伤特征研究
Sanjita Paudel,Hyunchae Sim,Eunjoo Kang et al.
Sanjita Paudel et al.
Formaldehyde (FA) is a well-known environmental toxicant used in various industries, including biomedical, agriculture, and textiles, but poses significant health risks. Despite extensive research, the exact hepatotoxic mechanism of FA rema...
Skin-Targeted AhR Activation by Microbial and Synthetic Indoles: Insights from the AhaRaCaT Reporter Cell Line [0.03%]
微生物和合成吲哚通过AhaRaCaT报告细胞系介导的皮肤靶向AhR激活：见解
Radim Vrzal,Aneta Grycová,Aneta Vrzalová
Radim Vrzal
Disruption of the epidermal barrier contributes to skin disorders such as atopic dermatitis and psoriasis. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, plays a key role in skin homeostasis and immune regulat...
Establishing scientific confidence in a two-chamber co-culture system to evaluate androgenic response in the presence of hepatic metabolism [0.03%]
建立科学信心，使用双室共培养系统评估肝代谢存在下的雄激素反应
Tessa C A van Tongeren,Susan J Hall,Samantha J Madnick et al.
Tessa C A van Tongeren et al.
For the in vitro determination of toxicity on target organs in the presence of physiologically relevant human metabolism, we recently developed a two-chamber liver-target organ co-culture system in a medium-throughput 96-well format. Our pr...
Safety assessment of endotoxin related to drug products and medical devices: a review [0.03%]
与药品和医疗器械相关的内毒素安全评估：综述
Frank Liu
Frank Liu
Endotoxin, also known as LPS, is the main component of the outer membrane of Gram-negative bacteria. It is released into the environment during cell division and cell death. Contamination of drug products and medical devices by endotoxin ha...