Pre-Clinical Safety Assessments of Gadobutrol in Diabetes-Induced Neuropathy: In Vivo, In Vitro and In Silico Studies [0.03%]
糖尿病周围神经病的钆布醇药代动力学及药效学研究：体内、体外和计算机仿真研究
Batuhan Bilgin,Munevver Gizem Hekim,Muhammed Adam et al.
Batuhan Bilgin et al.
Due to its vascular complications, patients with diabetes mellitus (DM) are exposed to gadobutrol in imaging. However, the safety concerns of gadobutrol to diabetes-induced neuropathy, a common complication of DM, remain unclear as a scient...
Individual and Mixed Effects of PFAS on Osteoporosis: Insights from Epidemiological and Bioinformatic Approaches [0.03%]
全氟和多氟烷基物质(PFAS)对骨质疏松症的个体效应与混合效应及人群流行病学和生物信息学研究视角
Wei Wei,Hongjin Huo,Xinxi Song et al.
Wei Wei et al.
This cross-sectional study investigated the associations between individual and mixed exposure to per- and polyfluoroalkyl substances (PFAS) and osteoporosis, and explored potential biological mechanisms in 2,764 U.S. adults. Multivariable ...
Microplastics as Vectors for Environmental Contaminants in the Food Chain: Assessing the Combined Toxicological Effects and Bioavailability [0.03%]
微塑料作为食物链中环境污染物的传播媒介：评估其联合毒理效应和生物可利用性
Jia Du,Linlin Qiu,Qingwei Zhou et al.
Jia Du et al.
The global proliferation of microplastics (MPs) and nanoplastics (NPs) has raised concerns not only for their persistence in ecosystems but also for their role as transport agents of environmental contaminants through food chains. This revi...
Meixiu Duan,Youliang Zhao,Yaqian Qu et al.
Meixiu Duan et al.
Silica exposure can cause silicosis, and its pathogenesis is not fully understood. This study investigates the role of immune checkpoint lymphocyte activation gene 3 (LAG3) in silicosis. Mice were intratracheally exposed to silica, and tiss...
Constitutive Androstane Receptor activation modulates YAP expression and activity through ubiquitination and sumoylation [0.03%]
构成型雄甾烷受体通过泛素化和SUMO化调节YAP的表达和活性
Fengting Liang,Shuaishuai Zhang,Wenhong Zhou et al.
Fengting Liang et al.
Constitutive Androstane Receptor (CAR) is a member of the nuclear receptor superfamily that significantly contributes to the metabolism of endogenous and exogenous substances and the homeostatic regulation of the body. Yes-associated protei...
Follicular and Neural Toxic effect of prolonged exposure of synthetic dye Fast green FCF (E143) - Insights from Zebrafish Model [0.03%]
长期暴露于合成染料Fast green FCF(E143)对卵泡和神经的毒性作用-斑马鱼模型的新见解
Gokul Sudhakaran,P Snega Priya,Raghul Murugan et al.
Gokul Sudhakaran et al.
This study highlights the toxic effects of prolonged exposure of synthetic food dye fast green FCF (E143) in zebrafish and the cumulative consequences of such exposure on multiple biological systems mainly neural and reproductive. Chronic e...
Studying APAP metabolism in a cohort of intoxicated patients using HRMS-based profiling: detection of catechol and delayed thiomethyl metabolites [0.03%]
基于HRMS的代谢组学在乙酰氨基酚中毒患者中的应用： catechol和延迟性硫甲基代谢产物的检测
Thomas Gicquel,Romain Pelletier,Eva Gorrochategui et al.
Thomas Gicquel et al.
Acetaminophen (APAP) overdose is one of the most important causes of drug-induced liver injury worldwide. Hepatotoxicity induced by APAP is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermed...
Physiologically based toxicokinetic models in aggregate exposure: a review [0.03%]
基于生理的毒物动力学模型在总体暴露评估中的应用研究综述
L Lamon,A Paini,M Siccardi et al.
L Lamon et al.
This literature review explores the application of Physiologically Based Kinetic (PBK) models in aggregate exposure (AE) assessment across different chemical classes. It builds on the screening of 1119 publications and the identification of...
Distinct responses of the constitutive androstane receptor NR1I3 to indole-containing metabolites of bacterial origin [0.03%]
吲哚类细菌代谢产物对构成性雄烷受体NR1I3的不同响应
Ryuya Narita,Misaki Kaito,Takashi Kondo et al.
Ryuya Narita et al.
The constitutive androstane receptor (CAR, NR1I3) has been recognised as a nuclear receptor for various xenobiotics, such as barbiturates and dietary polyphenols. In this study, the CAR responded to internal metabolites produced by intestin...
The association between urinary levels of organic phosphorus insecticide exposure and subclinical thyroid disorders [0.03%]
尿液有机磷农药水平与亚临床甲状腺功能障碍的关系分析
Gaohui Wei,Yi Shen,Xian Wang et al.
Gaohui Wei et al.
Objective: Studies have shown that exposure to organophosphorus pesticides (OPPs) may disrupt thyroid endocrine function in animal models and in agroforestry practitioners, leading to subclinical hyperthyroidism (SHyper)....