Size- and morphology-dependent cytotoxicity of metal-organic frameworks: Deciphering the structure-toxicity relationship [0.03%]
金属有机框架的尺寸和形态依赖性细胞毒性：结构毒理学关系解析
Rui Liu,Jinhuo Li,Xueting Yan et al.
Rui Liu et al.
Metal-organic frameworks (MOFs), as an emerging nanomaterial, have been widely used in the field of biomedicine due to their excellent loading performance. However, the unclear synergistic biological toxicity associated with variations in t...
Steroidogenesis suppression in H295R cells by 1,3-disubstituted ureas: A potential off-target effect of some sEH inhibitors [0.03%]
1,3-二取代脲通过H295R细胞类固醇生物合成的抑制：某些sEH抑制剂的潜在非靶效应
Ya-Chen Hsu,Annabella D Lynch,Christophe Morisseau et al.
Ya-Chen Hsu et al.
The soluble epoxide hydrolase (sEH) is widely studied for its therapeutic potential in inflammation, cardiovascular disease, and pain through stabilization of endogenous epoxyeicosatrienoic acid (EET). Here, we evaluated the impact of sever...
Signaling pathways in tobacco smoking-induced cervical carcinogenesis: Beyond HPV-mediated activation [0.03%]
烟草吸烟诱发宫颈癌变的信号通路：超越人乳头状瘤病毒介导的活化作用
Yuxin Hu,Xilei Liu,Zhongwei Zhang et al.
Yuxin Hu et al.
Tobacco smoking is a well-established cofactor for human papillomavirus (HPV) in the development of cervical cancer (CC), but it also contributes to a subset of HPV-negative carcinomas. While the epidemiological link is clear, the molecular...
Neurobehavioral, cholinergic and histopathological alterations induced by copper oxide nanoparticles in male mice [0.03%]
铜氧化物纳米颗粒对雄性小鼠神经行为、胆碱能和组织病理学的影响
Rahma Ammar,Sabrine Ben Slimen,Abir Mhadhbi et al.
Rahma Ammar et al.
Copper is an essential element involved in metabolic processes in both plants and animals. However, in its nanoparticle form, copper is widely used in industrial and biomedical applications, raising concerns about its potential health risks...
Toxicology and biodistribution of plant-derived extracellular vesicles for drug delivery: Quality control, safety mechanisms, and translational testing priorities [0.03%]
基于植物的外泌体用于药物传输的安全性及质量控制、机制和转化试验优先事项毒理学及生物分布
Muhammad Tahir Naseem,Wajid Zaman
Muhammad Tahir Naseem
Plant-derived extracellular vesicles and plant-derived exosome-like nanoparticles are increasingly investigated as natural nanocarriers for drug delivery and as bioactive materials with intrinsic therapeutic potential. However, their transl...
Effects of combustible cigarettes and heated tobacco products on immunomodulatory and hepatoprotective properties of mesenchymal stem cells in acute liver failure [0.03%]
可燃香烟和加热烟草产品对急性肝功能衰竭中免疫调节和保护肝细胞属性的影响研究
Dragica Pavlovic,Dragana Papic,Nikolina Kastratovic et al.
Dragica Pavlovic et al.
Numerous experimental and clinical studies have indicated that mesenchymal stem cells (MSCs) and their secretome can modulate progression of acute liver failure (ALF). Our earlier research has demonstrated that exposure to cigarette smoke s...
Nonclinical safety evaluation strategies for mRNA/LNPs platform agents: Evidence from comprehensive animal toxicity studies [0.03%]
基于全面动物毒性研究的mRNA/LNP平台药物非临床安全评价策略证据分析
Jae-Hun Ahn,Na-Young Lee,Hee-Jin Bae et al.
Jae-Hun Ahn et al.
Antigen-encoded messenger RNA (mRNA) formulated with lipid nanoparticles (LNPs) represent a rapidly expanding platform technology, extending beyond prophylactic infectious disease vaccines into therapeutic applications. Despite their increa...
Bromacil attenuates benzo[a]pyrene cytotoxicity and mutagenesis through the AhR and Nrf2 pathways [0.03%]
溴氰菊酯通过AhR和Nrf2途径缓解苯并[a]芘细胞毒性和致突变性
Mebae Koike,Shun Takemoto,Showa Komatsu et al.
Mebae Koike et al.
The aryl hydrocarbon receptor (AhR) is known to respond to various chemicals as a sensor for environmental chemicals that induce drug-metabolizing enzymes; however, reports on its activation by pesticides and herbicides remain limited. We e...
MC-LR detoxication in human and rats: inter-organ and inter-species differences [0.03%]
人体和大鼠MC-LR解毒作用的器官差异及物种差异研究
Verdiana Malandrucco,Nicoletta Santori,Jean-Lou C M Dorne et al.
Verdiana Malandrucco et al.
The transition from animal-based chemical risk assessment to Next-Generation Risk Assessment requires the integration of human-relevant New Approach Methodologies and mechanistic kinetic data to support physiologically based kinetic (PBK) m...
Comparing the performance of solution-based decontaminants following exposure to toxic industrial chemicals on human skin [0.03%]
毒性工业化学品在人体皮肤上暴露后溶液去污剂的性能比较研究
Sharyn Gaskin,Ruchira Ranaweera,Leigh Thredgold et al.
Sharyn Gaskin et al.
The extensive use of industrial chemicals increases the likelihood of accidental or deliberate environmental release, potentially occurring in occupational, public, or military settings, with skin contact being an important route of exposur...