Dose-Dependent Effects of Chlorpyrifos on Liver Injury, Intestinal Dysbiosis, and Metabolic Perturbations in C57BL/6J Mice [0.03%]
氯吡硫磷对C57BL/6J小鼠肝脏损伤，肠道菌群失衡和代谢紊乱的剂量依赖性影响
Shuilin Wei,Mengjing Wu,Quanzhi Qin et al.
Shuilin Wei et al.
The organophosphorus pesticide chlorpyrifos (CPF) is widely utilized in agriculture to protect crops from pests and diseases. Concerns regarding its extensive use have emerged due to the substance's persistence, bioaccumulation, endocrine d...
Extended sub-chronic exposure to heavy metal mixture induced multidrug resistance against chemotherapy agents in ovarian cancer cells [0.03%]
重金属混合物的扩增亚慢性暴露诱导卵巢癌细胞对化疗药物的多药耐药性
Gözde Sahin,Zeynep Banu Doğanlar
Gözde Sahin
Recent scientific findings suggest that persistent, minimal quantity exposure to heavy metals combinations can instigate negative reactions across various cell types, tissues, and organs. However, the interplay between heavy metals present ...
Environmental pesticide exposure and its association with hematological parameters and inflammation indices among school-aged children in Mexico [0.03%]
环境中的农药暴露及其与墨西哥学龄儿童血液参数和炎症指数的关系
Miguel Alfonso Ruiz-Arias,Yael Yvette Bernal-Hernández,Irma Martha Medina-Díaz et al.
Miguel Alfonso Ruiz-Arias et al.
Few studies have investigated the association between pesticide exposure and immune-inflammatory indices in children. We conducted a cross-sectional study of 369 school-aged children from three Mexican communities with varying levels of agr...
Toxic effects of sterigmatocystin on porcine oocyte maturation and subsequent embryo development [0.03%]
棒曲霉素对猪卵母细胞成熟及随后胚胎发育的毒性效应
Yumin Lee,Dabin Cha,Seunghyun Choi et al.
Yumin Lee et al.
Sterigmatocystin (STE), a precursor of aflatoxin B1, is one of the mycotoxins that easily contaminates feed. Although previous studies have suggested the toxic effects of aflatoxin B1 on oocyte maturation, little attention has been given to...
Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells [0.03%]
吸烟通过调控人类ARNT和AHRR影响A549细胞中CYP1A1 mRNA的诱导生成
Takumi Nakano,Masataka Nakano,Tatsuki Fukami et al.
Takumi Nakano et al.
N6-Methyladenosine (m6A) modification is a common epitranscriptomic mark of eukaryotic RNAs. This modification is installed by a methyltransferase like 3 (METTL3)-METTL14 complex and is eliminated by fat mass and obesity-associated protein ...
Protective Role of Hepatic Non-Parenchymal Cells against Drug-Induced Hepatocyte Toxicity Using Perfluoropolyether-Based Microfluidic Devices [0.03%]
基于全氟聚醚的微流控装置中肝非实质细胞对药物诱导的肝毒性抵抗的保护作用
Mengyang Wang,Qiyue Zhang,Kazuma Aoki et al.
Mengyang Wang et al.
The role of hepatic non-parenchymal cells (NPCs) in drug-induced liver injury has been controversial. Utilizing our previously developed perfluoropolyether-based microfluidic devices-characterized by significantly reduced chemical absorptio...
Comparative effects of e-cigarette and conventional cigarette smoke on in vitro bronchial epithelial cell responses [0.03%]
电子烟和普通烟雾对培养的支气管上皮细胞反应的比较效果
K L Pleiss,D D Mosley,C D Bauer et al.
K L Pleiss et al.
Because of cigarette smoking, chronic lung diseases are the third leading cause of death in the United States. Electronic cigarettes (e-cig) were originally marketed as harm reduction devices for cigarette smokers due to low success rates w...
Analysis of structure phototoxicity relationship towards the de-risking of phototoxic liabilities in early drug discovery [0.03%]
结构光毒性关系的分析有助于早期药物发现中降低光毒性的风险
Takafumi Takai
Takafumi Takai
The in vitro phototoxicity assay using the 3T3 cell line is a widely used screening system to identify toxicity risk in humans after exposure to sunlight. The chemical structure of drugs itself is considered to be primarily involved in the ...
Gender-specific effects of prenatal polystyrene nanoparticle exposure on offspring lung development [0.03%]
孕前聚苯乙烯纳米粒子暴露对后代肺发育的性别特异性影响
Wenxia Bu,Mengjiao Yu,Xinyi Ma et al.
Wenxia Bu et al.
Nanoplastics are widely present in the environment. Exposure to environmental pollutants during pregnancy can have adverse effects on fetal development and health. Establishing a link between nanoplastics and Bronchopulmonary Dysplasia (BPD...
Lithium attenuates ketamine-induced long-term neurotoxicity through DISC1-mediated GSK-3β/β-catenin and ERK/CREB pathways [0.03%]
锂通过DISC1介导的GSK-3β/β-catenin和ERK/CREB通路减轻氯胺酮诱导的长期神经毒性
Ting-Ting Yang,Zi-Wen Guo,Fang Zhang et al.
Ting-Ting Yang et al.
Ketamine, an antagonist of N-methyl-D-aspartate receptor, is extensively employed in pediatric anesthesia. Multiple studies have shown that repeated ketamine exposure induces neuroapoptosis, synaptic changes and cognitive deficits during ne...