Fecal metabonomics combined with 16S rRNA gene sequencing to study the mechanisms of cantharidin-induced hepatotoxicity [0.03%]
结合代谢组学及16S rrna测序研究斑蝥素肝毒作用机制
Lijuan Xiong,Jialu Zou,Kexin Lin et al.
Lijuan Xiong et al.
Cantharidin (CTD) serves as the principal bioactive compound in traditional Chinese medicine Mylabris, commonly employed in cancer treatment. Nevertheless, the clinical application of CTD is partly restricted by hepatotoxicity, and the toxi...
Exposure to pesticides and cognitive function in school-age children of the Bolivar Department (Colombia) [0.03%]
哥伦比亚玻利瓦尔地区学龄儿童接触农药与认知功能的关系
Maria Quintana-Mejia,Flor Palacio-Herrera,Jesus Olivero-Verbel et al.
Maria Quintana-Mejia et al.
Joining efforts to address the interactions between social and environmental determinants of cognitive functioning allows the identification of structural barriers that guide government plans towards the fulfillment of the 2030 Agenda. This...
The Role of the Gut Microbiome in the Associations Between Lead Exposure and Child Neurodevelopment [0.03%]
肠道微生物组在铅暴露与儿童神经发育关系中的作用
Amanda C Wylie,Nicolas Murgueitio,Alexander L Carlson et al.
Amanda C Wylie et al.
Lead is highly toxic to the developing brain. Given its persistence in the environment, new intervention strategies are needed to mitigate the impacts of lead on child neurodevelopment. The gut microbiome, referring to the bacteria and micr...
Multi-approach study on diethylhexyl phthalate and monoethylhexyl phthalate binding to lysozyme: In silico, bioactivity and surface plasmon resonance analyses [0.03%]
二乙基己基邻苯二甲酸和单乙基己基邻苯二甲酸与溶菌酶结合的多方法研究：基于计算机、生物活性及表面等离子体共振分析
Müfide Aydoğan Ahbab,Ilgaz Taştekil,Evren Gazel Pinar et al.
Müfide Aydoğan Ahbab et al.
Diethylhexyl phthalate (DEHP) and its metabolite monoethylhexyl phthalate (MEHP) are recognized as endocrine disruptors with significant toxicological effects on various human physiological systems. While previous research has explored phth...
Synergistic Cardiotoxic Effects of Captagon and Azithromycin in Rat via Oxidative stress, Apoptosis and Upregulation of the PI3K/AKT/NF-kB pathway [0.03%]
卡巴胆碱和阿奇霉素在大鼠中的协同心毒性作用：通过氧化应激、凋亡及PI3K/AKT/NF-кB通路的上调实现
Shaimaa A Shehata,Noha M Abd El-Fadeal,Islam Omar Abdel Fattah et al.
Shaimaa A Shehata et al.
Fenethylline (Captagon) is a blend of amphetamine and theophylline that functions as a stimulant, while azithromycin (AZ) is a commonly prescribed macrolide antibiotic. The co-usage of illicit substances and therapeutic drugs can result in ...
Shivani Dixit,Ram Kumar Dhaked,T S Greeshma et al.
Shivani Dixit et al.
Ricin, a type-2 Ribosome-Inactivating Protein (RIP), is a dangerous biotoxin derived from castor plant seeds. It is classified as a Schedule 1 agent by the Chemical Weapon Convention (CWC) and a Category B agent by the Biological and Toxin ...
Xiaoyu Mao,Dashuang Mo,Yuqin Cheng et al.
Xiaoyu Mao et al.
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a commonly used antioxidant in tire manufacturing, has been widely detected in the environment and shown to exhibit acute toxicity in several organs. However, the effects of 6PPD on...
Exploring Gadolinium Deposition in Maternal and Offspring Mice: Impacts of Gestational and Lactational Exposure [0.03%]
探索母鼠和子代鼠体内钆沉积情况：妊娠期和哺乳期暴露的影响
Ying Kong,Kai Liu,Shi Qiu et al.
Ying Kong et al.
To investigate the gadolinium deposition induced by repeated administration of gadolinium-based contrast agents (GBCAs) in multi-organ/tissue of mother and pup mice during pregnancy and lactation, two hundred and seventy ICR mice were divid...
Do urinary metabolites reflect occupational exposure to organophosphate flame retardants? A case study in electronic waste recycling workers [0.03%]
尿代谢产物能反映作业环境中有机磷类阻燃剂的暴露吗？一项电子废弃物回收工人的案例研究
Sabrina Gravel,Inna Tata Traore,Miriam L Diamond et al.
Sabrina Gravel et al.
Organophosphate esters (OPEs) are commonly used in electronic devices to meet safety standards, but electronic-waste recycling (e-recycling) workers may face significant exposure to those potentially hazardous compounds in their workplace. ...
Using Explainable Machine Learning to Predict the Irritation and Corrosivity of Chemicals on Eyes and Skin [0.03%]
使用可解释机器学习预测化学品对眼睛和皮肤的刺激性和腐蚀性
Yingxu Liu,Yang Liu,Simeng Zhang et al.
Yingxu Liu et al.
Contact with specific chemicals often results in corrosive and irritative responses in the eyes and skin, playing a pivotal role in assessing the potential hazards of personal care products, cosmetics, and industrial chemicals to human heal...