Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window [0.03%]
在雄性化编程窗口期间，子宫内暴露于DBP和DINP的Wistar大鼠胎儿和成年雄性生殖系统的系统比较研究
Sander van den Driesche,Serena Shoker,Fiona Inglis et al.
Sander van den Driesche et al.
This study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) during the masculinisation programming window (MPW) which is embryonic ...
Comparative Study
Toxicology letters. 2020 Dec 15:335:37-50. DOI:10.1016/j.toxlet.2020.10.006 2020
JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma [0.03%]
JNK调节RAGE/β-连环蛋白信号在哮喘过敏性气道炎症中的作用不可缺少
Guohua Huang,Jinwei Su,Wenqu Zhao et al.
Guohua Huang et al.
As a leading cause of occupational asthma, toluene diisocyanate (TDI)-induced asthma is an inflammatory disease of the airways with one of the most significant characteristics involving inflammation, in which the receptor of advanced glycat...
A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation [0.03%]
长链非编码RNA Gpr137b-ps/miR-200a-3p/CXCL14轴调节肝星状细胞(HSC)的激活
Jinmao Liao,Zheng Zhang,Qi Yuan et al.
Jinmao Liao et al.
Hepatic fibrosis is the wound healing response upon the liver tissue damage caused by multiple stimuli. Targeting activated hepatic stellate cells (HSCs), the major extracellular matrix (ECM)-producing cells within the damaged liver, has be...
Corrigendum to "Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone" [Toxicol. Lett. 284 (2018) 184-194] [0.03%]
对“来自人皮肤前体细胞的肝细胞在接触胺碘酮后显示出典型的磷脂反应”[毒理学通讯。 284（2018）184-194]的勘误表
Alessandra Natale,Joost Boeckmans,Terry Desmae et al.
Alessandra Natale et al.
Published Erratum
Toxicology letters. 2020 Oct 15:333:322-323. DOI:10.1016/j.toxlet.2020.09.014 2020
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis [0.03%]
尼古丁通过加重阻塞性肺泡巨噬细胞自噬降解导致硅沉着病凋亡
Shi Chen,Shiyi Tan,Shang Yang et al.
Shi Chen et al.
Silica dust mainly attacks alveolar macrophages (AMs). The apoptosis of AMs is correlated with the progress of silicosis. Our previous study showed that autophagic degradation was blocked in AMs from silicosis patients. However, the effects...
Human skin permeation rates ex vivo following exposures to mixtures of glycol ethers [0.03%]
人类皮肤ex vivo暴露于多种二醇醚混合物后的渗透率
Aurélie Berthet,Christelle Oltramare,Philipp Spring et al.
Aurélie Berthet et al.
Skin exposure to cleaning products in the general and occupational population are a public health concern. Among the most frequently identified amphiphilic organic solvents in cleaning products are propylene glycol monomethyl ether (PGME) a...
Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor [0.03%]
吲哚微生物肠道代谢物扩增了人类孕烷X受体的配体和激动剂的数量
Peter Illés,Kristýna Krasulová,Barbora Vyhlídalová et al.
Peter Illés et al.
The interplays between the metabolic products of intestinal microbiota and the host signaling through xenobiotic receptors, including pregnane X receptor (PXR), are of growing interest, in the context of intestinal health and disease. A dis...
The mycotoxin beauvericin impairs development, fertility and life span in the nematode Caenorhabditis elegans accompanied by increased germ cell apoptosis and lipofuscin accumulation [0.03%]
霉菌毒素beauvericin通过增加生殖细胞凋亡和类脂褐素的堆积从而危害秀丽隐杆线虫的发展，繁殖率和寿命
Christian Büchter,Karoline Koch,Martin Freyer et al.
Christian Büchter et al.
Beauvericin is an ubiquitous mycotoxin with relevant occurrence in food and feed. It causes a high toxicity in several cell lines, but its general mechanism of action is not fully understood and only limited in vivo studies have been perfor...
Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice [0.03%]
秋水仙碱增加肠道通透性、抑制炎症反应并改变小鼠的肠道微生物群
Yongpeng Shi,Jiande Li,Pengfei Yang et al.
Yongpeng Shi et al.
Although colchicine (COL) has been used to treat gout for more than a thousand years, it has been shrouded in a dark history for a long time due to its high toxicity, especially for the gastrointestinal tract. With the widespread clinical a...
Corrigendum to "Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis" [Toxicol. Lett. 301 (2019) 53-63] [0.03%]
勘误表 对于 "甲基苯丙胺通过miR-143/PUMA轴诱导NLRP3炎症小体介导的小胶质细胞活化" [毒理学通讯。 301 (2019) 53-63]
Longfei Du,Kai Shen,Ying Bai et al.
Longfei Du et al.
Published Erratum
Toxicology letters. 2020 Oct 15:333:324-325. DOI:10.1016/j.toxlet.2020.09.002 2020