Rubber-Derived Contaminants N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone Alter Intergenerational Cholesterol Metabolism in F1 Offspring of Exposed Mice [0.03%]
橡胶衍生污染物N-(1,3-二甲基丁基)-N'-苯基对苯二胺及其醌类衍生物可致暴露小鼠F1代子代胆固醇代谢紊乱
Liya Fang,Chanlin Fang,Shanshan Di et al.
Liya Fang et al.
This study examined the hepatic effects of parous exposure to the rubber-derived contaminant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation product, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6P...
An integrated in vitro and in silico testing strategy applied to PFAS inhibition of antibody production to define a tolerable daily intake [0.03%]
一种应用于PFAS的体外和计算机模拟结合测试策略，以界定可耐受每日摄入量来抑制抗体生成
Martina Iulini,Aafke W F Janssen,Karsten Beekmann et al.
Martina Iulini et al.
Per- and polyfluoroalkyl substances (PFAS) are widely used chemicals known for their persistence, bioaccumulation, and adverse health effects, particularly on the immune system. Epidemiological studies link PFAS exposure to immunosuppressio...
Mechanisms, pathological features, and intervention strategies for nitrogen mustard-induced skin toxicity [0.03%]
氮芥致皮肤毒性的机制、病理特征及干预策略
Bing Zhu,Guanchao Mao,Qinghe Meng et al.
Bing Zhu et al.
Nitrogen mustard (NM) is a representative alkylating vesicant that produces severe and long-lasting damage to the skin. This review summarizes current understanding of its pathological features, molecular mechanisms, and therapeutic approac...
Predicting acute developmental toxicity of chemicals in embryos of the African clawed frog (Xenopus laevis): calibration and validation of regression-based quantitative structure activity relationship models for hazard assessment of chemicals in anuran amphibians [0.03%]
基于回归的定量构效关系模型在非洲爪蟾胚胎发育毒性预测中的校准和验证：轴突类两栖动物化学物质危害评估的发展毒理学研究
Christian Novello,Matteo Riccardo Di Nicola,Jean Lou Cm Dorne et al.
Christian Novello et al.
Global decline of amphibian populations has been correlated with a range of endogenous and exogenous variables including their unique physiology and ecology, exposure to chemicals, habitat reduction, climate change, as well as biological ha...
Effects of cannabidiol on the viability and neuronal differentiation of human iPS cells [0.03%]
大麻二酚对人类IPS细胞存活率和神经元分化的影响
Koushirou Sogawa,Masahiko Funada
Koushirou Sogawa
Cannabidiol (CBD) is a non-psychoactive cannabinoid with increasing global use, yet safety data during pregnancy remain limited. Preclinical studies suggest possible developmental neurotoxicity. Here, we examined the effects of CBD (0.001-1...
Organic matter of PM2.5 induces cardiomyocyte toxicity by driving oxidative potential and impairing AMPK/PGC-1α-dependent mitochondrial biogenesis [0.03%]
颗粒物PM2.5中的有机组分通过驱动氧化潜能和损害AMPK/PGC-1α依赖性的线粒体生物生成诱导心肌细胞毒性
Shanshan Chen,Wenqi Chen,Hong Geng et al.
Shanshan Chen et al.
Introduction: While fine particulate matter (PM2.5) is an established risk factor for cardiovascular disease (CVD), the relative contribution of its specific chemical components to cardiotoxicity remains unclear. This stu...
Research on the Therapeutic Effects of Recombinant Protein PON1Q/R192 Intervention on Mice Poisoned by Different Categories of Organophosphorus Compounds [0.03%]
重组蛋白PON1Q/R192对不同种类有机磷化合物中毒小鼠治疗作用的研究
Shuang Zhou,Yue Cui,Lu Li et al.
Shuang Zhou et al.
Organophosphorus compounds are widely used in agriculture, but their poisoning poses a great threat. This study focuses on exploring the therapeutic effects of rePON1Q192 and rePON1R192 on mice poisoned with different types of organophospho...
Comparative Transcriptomic Analysis Reveals STAT3 as a Candidate Gene Involved in Aristolochic Acid I-Induced Hepatorenal Toxicity [0.03%]
比较转录组分析发现STAT3是马兜铃酸I诱导肝肾毒性关联基因筛查中的候选基因
Gerui Zhu,Fan Wang,Siyuan Wang et al.
Gerui Zhu et al.
Aristolochic acids, such as Aristolochic acid I (AAI), are widely recognized for their nephrotoxicity and potential to cause hepatocellular carcinoma. Although previous studies have demonstrated the ability of AAI to induce hepatorenal toxi...
Advances in Understanding the Neurotoxicity of Lead, Cadmium, Arsenic, and Therapeutic Strategies [0.03%]
铅、镉、砷的神经毒理作用研究进展及治疗策略
Yi-Ling Li,Zhi-Xin Huang,Jian-Chao Peng et al.
Yi-Ling Li et al.
The rapid progression of industrialization and urbanization has intensified the public health threat posed by heavy metal pollution. Among these, lead (Pb), cadmium (Cd), and arsenic (As) are pervasive environmental toxicants capable of ent...
Association between polycyclic aromatic hydrocarbons (PAHs) and insulin resistance: A comprehensive study utilizing NHANES data and network toxicology [0.03%]
利用NHANES数据和网络毒理学全面研究多环芳烃(PAHs)与胰岛素抵抗之间的关系
Longbao Xu,Lerong Cheng,Hanqing Wu et al.
Longbao Xu et al.
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants with potential endocrine-disrupting effects, yet prior epidemiological research on their association with insulin resistance has yielded inconsistent results. U...