Hierarchical mathematical modelling of patients with myeloproliferative neoplasms captures interferon-α treatment responses and allows for personalised and population predictions [0.03%]
层次数学模型揭示干扰素-α治疗真性红细胞增多症的机制并可用于个性化及群体预测
Tobias Idor Boklund,Gurvan Hermange,Jordan Snyder et al.
Tobias Idor Boklund et al.
The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are a group of haematological malignancies triggered by a driver mutation, most commonly the JAK2 V617F mutation, which is acquired in a haematopoietic stem cell. The ...
Coupled Information-Epidemic Dynamics with Emotional Thresholds and Behavioral Regression on multiplex networks [0.03%]
具有情感阈值和行为回归的复网络上的耦合信息传播动力学
Xunyang Wang,Ning Wei,Chunmiao Xu
Xunyang Wang
During prolonged epidemics, public adherence to protective measures often wanes due to behavioral fatigue-a dynamic psychological process typically overlooked in existing models. We propose a coupled Unaware-Positive-Negative-Unaware and Su...
Exploration of Hepatitis B Virus Infection Dynamics through Physics-Informed Deep Learning Approach [0.03%]
基于物理知识的深度学习方法探索乙型肝炎病毒感染动力学规律研究
Bikram Das,Rupchand Sutradhar,D C Dalal
Bikram Das
Accurate forecasting of viral disease outbreaks is crucial for guiding public health responses and preventing widespread loss of life. Recently, Physics-Informed Neural Networks (PINNs) have emerged as a promising framework for capturing vi...
Bistability Analysis of a Hybrid Notch-Delta Signaling Model in a Single Cell Interacting with Fixed External Proteins [0.03%]
单个细胞与固定外部蛋白相互作用的Notch-Delta信号杂交模型的双稳性分析
Yuxin Liang,Ling Xue,Kun Zhao et al.
Yuxin Liang et al.
Notch-Delta signaling is a juxtacrine cell-fate pathway that drives lateral inhibition, whereby neighboring cells adopt alternating Sender (high Delta/low Notch) and Receiver (high Notch/low Delta) states. This bistability is captured by th...
Modeling melanoma-immune interactions with a physiological delay incorporating dendritic cell vaccines and anti-PD-1 therapy [0.03%]
带有生理延迟的黑色素瘤免疫相互作用模型及其在树突状疫苗和抗PD-1疗法中的应用
Yang Dai,Zhihui Ma
Yang Dai
Malignant melanoma is an aggressive skin cancer with limited responsiveness to traditional therapies. Notably, the combination of dendritic cell (DC) vaccines with anti-programmed cell death protein 1 (anti-PD-1) therapy has shown stronger ...
Stability of linear delay differential systems via Laplace transformation [0.03%]
拉普拉斯变换在求解线性时滞微分系统稳定性中的应用
Muhammad Naeem,Yang Kuang,Jiaxu Li
Muhammad Naeem
We present a Laplace transform approach for explicitly solving linear delay differential systems with multiple discrete delays by applying the Cauchy residue theorem. This method enables direct determination of the stability of the trivial ...
Spatial dynamics of a pest population with stage-structure and control in a temporally periodic environment [0.03%]
具有阶段性结构的害虫种群时空动力学模型及控制策略研究
Stephen Becklin,Yu Jin,Brigitte Tenhumberg
Stephen Becklin
In this paper, we study an integro-difference model for a pest population with four life stages in a temporally periodic environment. We assume spatial dispersal in the adult stage and pest control can be applied to all stages. When the spa...
Simulating reentrant mechanisms under structural remodeling: A computational model based on complex-order operators [0.03%]
基于复杂阶运算器的结构重塑下再入机制的模拟的计算模型
Juan P Ugarte,Catalina Tobón
Juan P Ugarte
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is strongly associated with electrical and structural remodeling. Fibrosis, a hallmark of structural remodeling, alters myocardial conduction through architectu...
Anticipating critical transitions in fear-mediated mutualistic ecological system: Effects of stochasticity and early warning signals [0.03%]
恐惧介导的互利生态系统的临界过渡预测：随机性和预警信号的影响
Md Kausar Sk,Suvranil Chowdhury,Md Sayeed Anwar et al.
Md Kausar Sk et al.
Predators rarely forage with fixed efficiency; they cooperate, adjust their search effort to prey availability, and impose non-consumptive effects such as fear, while prey often respond through mutualistic associations with non-prey partner...
A practical introduction to ODE modelling in Stan for biological systems [0.03%]
基于Stan的生物系统ODE建模实用导论
Sara Hamis,John Forslund,Cici Chen Gu et al.
Sara Hamis et al.
Integrating dynamical systems models with time series data is a central part of contemporary mathematical biology. With the rich variety of available models and data, numerous methods and computational tools have been developed for these pu...