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Hierarchical mathematical modelling of patients with myeloproliferative neoplasms captures interferon-α treatment responses and allows for personalised and population predictions

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The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are a group of haematological malignancies triggered by a driver mutation, most commonly the JAK2 V617F mutation, which is acquired in a haematopoietic stem cell. The diseases are charact... ...