Ina Anreiter,Quoseena Mir,Jared T Simpson et al.
Ina Anreiter et al.
Modified nucleotides in mRNA are an essential addition to the standard genetic code of four nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics examines nucleotide modifications in mRNA and their impa...
The Formidable Challenge of Controlling High Mannose-Type N-Glycans in Therapeutic mAbs [0.03%]
治疗性抗体药物中高甘露糖型N-聚糖的去除难题
Renato Mastrangeli,Maria Concetta Audino,Wolf Palinsky et al.
Renato Mastrangeli et al.
The clinical efficacy and safety of therapeutic monoclonal antibodies (mAbs) are significantly affected by their Fc-glycosylation profile. High mannose-type N-glycans (HM) affect efficacy (in terms of antibody-dependent cell cytotoxicity), ...
Working Hard or Hardly Working? Regulatory Bottlenecks in Developing a COVID-19 Vaccine [0.03%]
努力工作还是几乎不工作？制定新冠肺炎疫苗的监管瓶颈问题
Lisette Pregelj,Damian C Hine,Maria G Oyola-Lozada et al.
Lisette Pregelj et al.
Vaccine solutions rarely reach the public until after an outbreak abates; an Ebola vaccine was approved 5 years after peak outbreak and SARS, MERS, and Zika vaccines are still in clinical development. Despite massive leaps forward in rapid ...
Matthias W Laschke,Thomas Später,Michael D Menger
Matthias W Laschke
Adipose tissue-derived microvascular fragments serve as natural vascularization units in angiogenesis research and tissue engineering due to their ability to rapidly reassemble into microvascular networks. Recent studies indicate that they ...
Alan Costello,Ahmed H Badran
Alan Costello
Synthetic biology strives to reliably control cellular behavior, typically in the form of user-designed interactions of biological components to produce a predetermined output. Engineered circuit components are frequently derived from natur...
Marta V Semkiv,Justyna Ruchala,Kostyantyn V Dmytruk et al.
Marta V Semkiv et al.
Industrial production of glycerol by yeast, which began during WWI in the so-called Neuberg fermentation, was the first example of metabolic engineering. However, this process, based on bisulfite addition to fermentation liquid, has many dr...
Technologies and Standardization in Research on Extracellular Vesicles [0.03%]
extracellular vesicles研究的技术和标准化问题
Srujan Gandham,Xianyi Su,Jacqueline Wood et al.
Srujan Gandham et al.
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various cells into physiological fluids. EV-mediated transfer of biomolecule...
Allergenicity Assessment of Novel Food Proteins: What Should Be Improved? [0.03%]
新型食品蛋白质过敏性评估：有待改进之处？
Antonio Fernandez,E N Clare Mills,Frits Koning et al.
Antonio Fernandez et al.
Allergenicity prediction is one of the most challenging aspects in the safety assessment of foods derived from either biotechnology or novel food proteins. Here we present a bottom-up strategy that defines a priori the specific risk assessm...
Sustainable Transformation of Land-Based Economic Development in the Era of Digital Revolution [0.03%]
数字革命时代的陆基经济发展可持续转型研究
Chun Sheng Goh,Amanda Ahl,Wing Thye Woo
Chun Sheng Goh
Biotechnology will play a key role in transforming current land-use systems alongside the digital revolution by using five strategies: enhancing productivity at the farm or plantation level, replenishing degraded land, enabling landscape ma...
Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing [0.03%]
迈向数字生物工艺复制品：生物制药研发和生产中的计算方法
Jens Smiatek,Alexander Jung,Erich Bluhmki
Jens Smiatek
Quantitative unit operation models for the optimization and refinement of modern late-stage biopharmaceutical drug manufacturing processes have recently attracted increasing attention. The supplementary benefits of these models include incr...