Shan Lin,Xiaolong Jiang,Jiaming Huang et al.
Shan Lin et al.
Industrial biosynthesis of next-generation human milk oligosaccharides (HMOs) is hindered by glycosyltransferase (GT) promiscuity, metabolic imbalance, and chassis safety. This forum highlights advances in GT engineering, dynamic metabolic ...
Sara Gerke,Jacob Balamut,Jennifer K Wagner
Sara Gerke
Replacing animal testing through 'New Approach Methodologies' holds promise for developing cheaper and safer drugs without animal suffering. However, such an approach should be implemented carefully, and it cannot be rushed. We discuss the ...
Thomas M Robinson,Yu Shrike Zhang,Khoon S Lim
Thomas M Robinson
Image-guided volumetric bioprinting allows for the adaptive fabrication of complex structures for tissue engineering. Seminal work by Florczak et al. introduces Generative, Adaptive, Context-Aware 3D Printing, a workflow that uses computer ...
Systematic engineering of Micromonospora echinospora cell factory for gentamicin C1a overproduction [0.03%]
系统工程改造微单孢菌胞工厂以增强链霉素C1a的生产
Feng Xu,Hao Gao,Rong Ben et al.
Feng Xu et al.
The clinical importance of gentamicin C1a as a broad-spectrum aminoglycoside antibiotic underscores the need for efficient biomanufacturing strategies. In this study, we developed a systematic engineering framework to enhance gentamicin C1a...
Precision insect control using programmable modular phage therapy platforms [0.03%]
使用可编程模块噬菌体治疗平台进行精准昆虫控制
Yichen Ding,Yunhua Zhang,Yaofeng Zhou et al.
Yichen Ding et al.
Invasive pest Spodoptera frugiperda, known as the fall armyworm (FAW), evolves rapid resistance to chlorantraniliprole (CAP) via symbionts, reducing traditional control efficacy and causing economic losses. To address the formidable challen...
Engineered coatings containing cyclic peptides from cyanobacteria delay the development of a stable macrofouling community [0.03%]
含有循环肽的涂层可延缓稳定大型污损群落的形成
Catarina Gonçalves,Sandra Pereira,Isabel B Oliveira et al.
Catarina Gonçalves et al.
Biofouling-the adhesion of organisms and their byproducts to submerged surfaces-poses economic and environmental challenges, highlighting the need for sustainable antifouling solutions. This study reports a proof-of-concept investigation in...
Connector-enabled integration of Golden Gate Assembly and yeast recombination for streamlined multigene pathway construction in the biofoundry workflow [0.03%]
用于生物工厂工作流程的金门装配和酵母重组连接集成化多基因途径构建方法
Min-Jun Seong,Haneul Kim,Hyewon Lee et al.
Min-Jun Seong et al.
Rewiring the metabolic flux for efficient microbial conversion requires robust, scalable gene assembly. However, conventional gene assembly approaches are labor-intensive, highly experience-dependent, and require extensive expertise to ensu...
Translational pathways for MSC secretome therapies: from bioprocessing to delivery [0.03%]
从生物加工到输送MSC分泌组疗法的转化途径
Maria Rossello-Gelabert,Natalia Escacena,Manoli Igartua et al.
Maria Rossello-Gelabert et al.
Mesenchymal stromal cells (MSCs) are multipotent, fibroblast-like cells known for their paracrine activity rather than long-term engraftment. Their secretome-the ensemble of soluble factors and extracellular vesicles released by these cells...
In situ engineering of synthetic yeast consortia for cross-species metabolic conversion of crude glycerol and byproducts into circular renewable bioenergy [0.03%]
用于粗甘油和副产物跨物种代谢转化的合成酵母菌群的原位工程化以形成循环可再生能源
Xiaoyu Shi,Joonhee Chang,Myeong-Eun Lee et al.
Xiaoyu Shi et al.
The rapid growth of biodiesel production generates large amounts of crude glycerol, a low-value byproduct with environmental and economic challenges. Here, we present an engineered yeast coculture system combining Saccharomyces cerevisiae a...
A synthetic biology roadmap for sustainable production of the plant-originated anti-cancer drug paclitaxel [0.03%]
可持续生产植物抗癌药物紫杉醇的人工合成生物学路线图
Chun-Lin Tan,Xin Yu,Hui-Cheng Feng et al.
Chun-Lin Tan et al.
Paclitaxel, a clinically potent anticancer drug derived from Taxus species, faces persistent challenges in sustainable supply. Synthetic biology presents substantial opportunities for its de novo production, particularly with recent breakth...