Pablo Di Giusto,Jasmine Tat,Nathan E Lewis
Pablo Di Giusto
Biotechnology and biopharma rely on detailed genome annotations for cell-line engineering, yet most production hosts are nonmodel organisms with limited resources linking sequence to physiology across space and time. A complete four-dimensi...
Scalable 4D biofabrication process for the manufacture of scaffold-free bone-forming callus implants [0.03%]
一种用于制造无支架骨愈合组织移植物的可扩展生物制造工艺
Andreas Dimopoulos,Konstantinos Ioannidis,Nikolaos S Giakoumakis et al.
Andreas Dimopoulos et al.
Critical-size long bone defects remain a major clinical challenge, with treatments such as autografts or distraction osteogenesis causing donor-site morbidity, infection, or failure to restore complex bone architecture. Tissue-engineered im...
Logic-gated CARs: a unified framework for programmable cell-based delivery systems [0.03%]
基于逻辑门控的CAR设计及其在细胞递送系统中的应用框架研究
Pu-Sheng Wei,Zitao Ma,Evelyn Chang et al.
Pu-Sheng Wei et al.
Logic-gated chimeric antigen receptors (CARs) enable engineered immune cells to integrate multiple molecular and environmental inputs, improving therapeutic precision, safety, and resistance to antigen escape. As diverse logic-gated CAR arc...
Linpeng Yu,Xing Liu,Huitong Wang et al.
Linpeng Yu et al.
Electric cues (ECs) permeate microbial habitats, yet electrosensing, the ability of microorganisms to detect and respond to these cues, remains largely overlooked. We distinguish four principal EC types [electric fields (EFs), electrode pot...
Engineered probiotics block arsenite absorption in the gastrointestinal tract [0.03%]
人造益生菌可阻挡胃肠中砷的吸收
Nhu Nguyen,Miaomiao Wang,Sithembiso S Msibi et al.
Nhu Nguyen et al.
Chronic exposure to arsenite in food and water is a major global health concern, yet no practical strategies exist to prevent ingested arsenite from entering the body through the gastrointestinal tract. Here, we engineered Escherichia coli ...
Emerging applications of Kluyveromyces marxianus in precision fermentation [0.03%]
Kluyveromyces marxianus在精准发酵中的新兴应用
Jolien Smets,Karin Voordeckers,Jan Steensels et al.
Jolien Smets et al.
Kluyveromyces marxianus is an emerging microbial cell factory characterized by rapid growth, strong thermo- and acid-tolerance, and broad substrate utilization, including second-generation feedstocks. Combined with substantial intraspecific...
Emerging applications of Kluyveromyces marxianus in precision fermentation [0.03%]
Kluyveromyces marxianus在精准发酵中新兴应用
Jolien Smets,Karin Voordeckers,Jan Steensels et al.
Jolien Smets et al.
Kluyveromyces marxianus is an emerging microbial cell factory characterized by rapid growth, strong thermo- and acid-tolerance, and broad substrate utilization, including second-generation feedstocks. Combined with substantial intraspecific...
María T Hernández-Huerta,Gilberto Castañeda-Hernández,Hector A Cabrera-Fuentes
María T Hernández-Huerta
Mexico's General Health Law regulates certain transfers abroad of human tissues used in population genomic studies. We clarify how this framework may apply to oriGen, why the nature of the material transferred is legally decisive, and why p...
Engineering omega-3 production in porcine adipocyte progenitors for nutritionally enhanced cultivated fat [0.03%]
工程改造猪脂肪细胞前体细胞以生产欧米伽-3脂肪酸用于营养增强型培育肉
Camilo Riquelme-Guzmán,Natsu Sugama,Anson Kwan et al.
Camilo Riquelme-Guzmán et al.
Omega-3 (n-3) fatty acids (FAs) are essential nutrients known for their health-promoting properties; however, they are frequently deficient in diets. To tackle these issues, new food technologies, including cultivated fat, enable the genera...
Conductive and magnetic silk biomaterials: functionalization strategies and challenges for sustainable bioelectronics [0.03%]
导电和磁性丝蛋白生物材料：可持续生物电子功能化策略与挑战
Gabriele Greco,Ferdinando Auricchio,Michele Conti et al.
Gabriele Greco et al.
Silk protein-based biomaterials are attractive because of their mechanical performance, biocompatibility, and processability into fibers, films, and hydrogels. Recent efforts have focused on integrating electrical conductivity and magnetic ...