Directed Evolution of CRISPR/Cas Systems for Precise Gene Editing [0.03%]
CRISPR/Cas系统导向进化在精准基因编辑中的应用
Rongming Liu,Liya Liang,Emily F Freed et al.
Rongming Liu et al.
CRISPR technology is a universal tool for genome engineering that has revolutionized biotechnology. Recently identified unique CRISPR/Cas systems, as well as re-engineered Cas proteins, have rapidly expanded the functions and applications o...
Engineered Methanotrophy: A Sustainable Solution for Methane-Based Industrial Biomanufacturing [0.03%]
工程甲烷营养型生物：甲烷基工业生物制造的可持续解决方案
Anh Duc Nguyen,Eun Yeol Lee
Anh Duc Nguyen
Methane is a promising feedstock with high abundance and low cost for the sustainable production of biochemicals and biofuels. Methanotrophic bacteria are particularly interesting platforms for methane bioconversion as they can utilize meth...
Joshua B McCluskey,Douglas S Clark,Dominic J Glover
Joshua B McCluskey
Combining the diverse chemical functionality of proteins with the predictable structural assembly of nucleic acids has enabled the creation of hybrid nanostructures for a range of biotechnology applications. Through the attachment of protei...
Burkholderia: An Untapped but Promising Bacterial Genus for the Conversion of Aromatic Compounds [0.03%]
伯克霍尔德菌属：一种用于芳香化合物转化的未经开发但有前景的细菌属
Raj Morya,Davinia Salvachúa,Indu Shekhar Thakur
Raj Morya
Burkholderia, a bacterial genus comprising more than 120 species, is typically reported to inhabit soil and water environments. These Gram-negative bacteria harbor a variety of aromatic catabolic pathways and are thus potential organisms fo...
Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals [0.03%]
工程化植物分泌途径以生产下一代药物
Emmanuel A Margolin,Richard Strasser,Ros Chapman et al.
Emmanuel A Margolin et al.
Production of biologics in plants, or plant molecular pharming, is a promising protein expression technology that is receiving increasing attention from the pharmaceutical industry. Previously, low expression yields of recombinant proteins ...
Shih-Hsin Ho,Congyu Zhang,Fei Tao et al.
Shih-Hsin Ho et al.
Microalgae are recognized as promising feedstocks for biofuel production and have been intensively studied. However, a systematic investigation of the relationship between cellular components and fuel properties in microalgae is currently a...
Anjun Ma,Adam McDermaid,Jennifer Xu et al.
Anjun Ma et al.
Fast-developing single-cell multimodal omics (scMulti-omics) technologies enable the measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA expression, protein abundance, gene perturbation, and spatial inf...
Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics [0.03%]
利用系统性红斑狼疮自身抗体进行生物药物的细胞内传递
Renata E Gordon,Jennifer F Nemeth,Sanjaya Singh et al.
Renata E Gordon et al.
Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficul...
Microbiome Engineering: Synthetic Biology of Plant-Associated Microbiomes in Sustainable Agriculture [0.03%]
微生物组工程：可持续农业中植物相关微生物组的合成生物学
Jing Ke,Bing Wang,Yasuo Yoshikuni
Jing Ke
To support an ever-increasing population, modern agriculture faces numerous challenges that pose major threats to global food and energy security. Plant-associated microbes, with their many plant growth-promoting (PGP) traits, have enormous...
Antonio Del Sol,Sascha Jung
Antonio Del Sol
The generation of large amounts of omics data is increasingly enabling not only the processing and analysis of large data sets but also the development of computational models in the field of stem cell research. Although computational model...