Ying Luo,Shen Pang,Hahk-Soo Kang et al.
Ying Luo et al.
Triacylglycerol (TAG) metabolism is increasingly recognized not as a static competitive sink but as a dynamic and programmable carbon reservoir in microbiology. This forum recapitulates this paradigm shift and highlights reprogramming strat...
Jieyu Ge,Tiange Wang,Chengyi Qu et al.
Jieyu Ge et al.
Published Erratum
Trends in biotechnology. 2026 May 9:S0167-7799(26)00181-2. DOI:10.1016/j.tibtech.2026.04.025 2026
Bioprinting is not cheap [0.03%]
生物打印并不便宜
Emma Petiot,Fabien Guillemot,Christophe Marquette
Emma Petiot
Bioprinting promises on-demand organs, but the reality is costly. From expensive bioinks and failed prints to clinical translation hurdles, every step demands significant financial and scientific investment. Recognizing these costs upfront ...
Blue at the edge [0.03%]
蓝天下的忧郁
Mauricio Lopez Portillo Masson,Michael Fox,Peter Lammers et al.
Mauricio Lopez Portillo Masson et al.
Zhenzhen Zhou,Yuan Pang,Zhendong Liao et al.
Zhenzhen Zhou et al.
The complexity and heterogeneity of the tumor microenvironment significantly influence cancer progression and therapeutic outcomes, highlighting the need for physiologically relevant in vitro models. In this study, we present vascularized t...
Yu Yao,Fei Yang
Yu Yao
Artificial intelligence can accelerate antibody discovery, potentially reshaping how inventions must be disclosed while raising standards for truly creative breakthroughs. This science and society article advocates modernizing 'undue experi...
Mary Gracen A Fuller,Matthew Foley,Rodolphe Barrangou
Mary Gracen A Fuller
While the advent of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based technologies has democratized the genesis of precise mutations, there is a need for more sophisticated tools to enable large-scale DNA manipulation...
A bacterial-derived quorum-sensing platform enables dynamic metabolic control in yeast [0.03%]
来自动物的群体感应途径能够用于酵母中的动态代谢控制
Haotian Zhai,Xinyue Liu,Pinzeng Guo et al.
Haotian Zhai et al.
Dynamic regulation of metabolic pathways is critical for optimizing microbial production, yet robust quorum-sensing (QS) systems remain largely unavailable in eukaryotic microorganisms. Here, we establish a bacterial-derived QS platform in ...
Integrated directed evolution and semirational design of Pyrococcus furiosus Argonaute for ultrasensitive tetracycline detection [0.03%]
结合集成定向进化和半理性设计的Pyrococcus furiosus Argonaute超灵敏四环素检测蛋白
Yanyan Chai,Bosheng Zhou,Wanqi Chen et al.
Yanyan Chai et al.
In this study, we report an integrated strategy combining directed evolution and semirational design to engineer a high-performance Pyrococcus furiosus Argonaute (PfAgo) variant. The optimized variant exhibited an 8.85-fold increase in cata...
Frans Kokojka,Denis Mulleman,Robert S Marks
Frans Kokojka
Therapeutic monoclonal antibodies can elicit anti-drug antibodies (ADAs) in patients, which impact drug pharmacokinetics, reduce efficacy, and occasionally cause hypersensitivity reactions. Growing evidence indicates that early detection of...