Self-Sufficient Class VII Cytochromes P450: From Full-Length Structure to Synthetic Biology Applications [0.03%]
自给型Cytochrome P450酶第七类：从全长结构到合成生物学应用
Danilo Correddu,Giovanna Di Nardo,Gianfranco Gilardi
Danilo Correddu
Members of class VII cytochromes P450 are catalytically self-sufficient enzymes containing a phthalate dioxygenase reductase-like domain fused to the P450 catalytic domain. Among these, CYP116B46 is the first enzyme for which the 3D structu...
Oxygen-Releasing Biomaterials: Current Challenges and Future Applications [0.03%]
释氧生物材料：当前挑战与未来应用展望
Niels G A Willemen,Shabir Hassan,Melvin Gurian et al.
Niels G A Willemen et al.
Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and n...
Human Blood-Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology [0.03%]
芯片上的仿人血脑屏障：病理生理学中独特的多细胞协作特征
Song Ih Ahn,YongTae Kim
Song Ih Ahn
Advances in stem cell engineering have opened new avenues for more accurately developing in vitro models of the human blood-brain barrier (BBB). Here, we highlight state-of-the-art human BBB-on-a-chip technologies and discuss the importance...
Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary [0.03%]
利用组织特异性微环境培养器官：生物假体卵巢的视角
Nathaniel F C Henning,Adam E Jakus,Monica M Laronda
Nathaniel F C Henning
Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such ...
Sasan Jalili-Firoozinezhad,Cláudia C Miranda,Joaquim M S Cabral
Sasan Jalili-Firoozinezhad
Animals often fail to faithfully mimic human diseases and drug toxicities, and most in vitro models are not complex enough to recapitulate human body function and pathophysiology. Organ-on-chip culture technology, however, offers a promisin...
Ioannis Prattis,Ernestine Hui,Patrik Gubeljak et al.
Ioannis Prattis et al.
Graphene and graphene-related materials (GRMs) exhibit a unique combination of electronic, optical, and electrochemical properties, which make them ideally suitable for ultrasensitive and selective point-of-care testing (POCT) devices. POCT...
Engineering Biocatalytic Solar Fuel Production: The PHOTOFUEL Consortium [0.03%]
工程生物催化太阳能燃料生产：PHOTOFUEL项目群
Julian Wichmann,Kyle J Lauersen,Natascia Biondi et al.
Julian Wichmann et al.
The EU Horizon2020 consortium PHOTOFUEL joined academic and industrial partners from biology, chemistry, engineering, engine design, and lifecycle assessment, making tremendous progress towards engine-ready fuels from CO2 via engineered pho...
Measurement Techniques to Resolve and Control Population Dynamics of Mixed-Culture Processes [0.03%]
混合培养过程种群动态的解析与控制测量方法研究进展
Ivan Schlembach,Alexander Grünberger,Miriam A Rosenbaum et al.
Ivan Schlembach et al.
Microbial mixed cultures are gaining increasing attention as biotechnological production systems, since they offer a large but untapped potential for future bioprocesses. Effects of secondary metabolite induction and advantages of labor div...
Ali Akbar Ashkarran,Jennifer Swann,Leah Hollis et al.
Ali Akbar Ashkarran et al.
The role of the 'file drawer' problem in nanomedicine, which partly drives the current limited clinical success of therapeutic nanoparticles, has been poorly investigated. We propose an integrated functioning of all stakeholders as the only...
Textile Triboelectric Nanogenerators for Wearable Pulse Wave Monitoring [0.03%]
用于穿戴式脉搏波监测的纺织摩擦电纳米发电机
Guorui Chen,Christian Au,Jun Chen
Guorui Chen
Arterial pulse waves are regarded as vital diagnostic tools in the assessment of cardiovascular disease (CVD). Because of their high sensitivity, rapid response time, wearability, and low cost, textile triboelectric nanogenerators (TENGs) a...