From Innovation to Application: Bridging the Valley of Death in Industrial Biotechnology [0.03%]
从创新到应用：工业生物技术跨越死亡之谷
Linde F C Kampers,Enrique Asin-Garcia,Peter J Schaap et al.
Linde F C Kampers et al.
Few biotechnology innovations make it through the Valley of Death to markets. Based on our experience with academia, technology transfer offices, and industry, we provide insights into differences in operating levels, how to best traverse t...
Sensors in blockchain [0.03%]
区块链中的传感器技术
Alara Altay,Robert Learney,Firat Güder et al.
Alara Altay et al.
Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measureme...
Overcoming functional challenges in autologous and engineered fat grafting trends [0.03%]
自体和工程脂肪移植的功能挑战及应对措施趋势分析
Gretel S Major,Jeremy W Simcock,Tim B F Woodfield et al.
Gretel S Major et al.
Autologous fat grafting offers significant promise for the repair of soft tissue deformities; however, high resorption rates indicate that engineered solutions are required to improve adipose tissue (AT) survival. Advances in material devel...
Mahmoud M Habashy,Ee Shen Ong,Omar M Abdeldayem et al.
Mahmoud M Habashy et al.
Annually, approximately 1.3 billion tons of food is lost worldwide, accounting for one-third of annual food production. Therefore, turning food waste into energy is of enormous environmental significance because of its sustainable nature. N...
Jiahui Zhang,Khalid Salaita
Jiahui Zhang
Nucleic acid therapeutics (NATs) hold promise in treating undruggable diseases and are recognized as the third major category of therapeutics in addition to small molecules and antibodies. Despite the milestones that NATs have made in clini...
CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility [0.03%]
基于CRISPR/Cas的表观基因组编辑：进展、应用及临床效用
Jacob H Goell,Isaac B Hilton
Jacob H Goell
The epigenome dynamically regulates gene expression and guides cellular differentiation throughout the lifespan of eukaryotic organisms. Recent advances in clustered regularly interspaced palindromic repeats (CRISPR)/Cas-based epigenome edi...
Can dispersal be leveraged to improve microbial inoculant success? [0.03%]
DISPERSAL：改善微生物接种剂效果的有效杠杆吗？
William L King,Terrence H Bell
William L King
Microorganisms have long been isolated from soils to develop microbial inoculants, with the goal of spiking them into new soils to augment target functions. However, establishment can be sporadic, and we assume that inoculants simply arrive...
Strategies for optimizing acetyl-CoA formation from glucose in bacteria [0.03%]
用于优化细菌中由葡萄糖形成乙酰辅酶A的策略
Li Zhu,Jieze Zhang,Jiawei Yang et al.
Li Zhu et al.
Acetyl CoA is an important precursor for various chemicals. We provide a metabolic engineering guideline for the production of acetyl-CoA and other end products from a bacterial chassis. Among 13 pathways that produce acetyl-CoA from glucos...
Bioengineered Microphysiological Placental Models: Towards Improving Understanding of Pregnancy Health and Disease [0.03%]
用于改善妊娠健康及疾病的胎盘微生理模型的生物工程学研究进展
Marnie Winter,Tanja Jankovic-Karasoulos,Claire T Roberts et al.
Marnie Winter et al.
Driven by a lack of appropriate human placenta models, recent years have seen the introduction of bioengineered in vitro models to better understand placental health and disease. Thus far, the focus has been on the maternal-foetal barrier. ...
Engineering Minds? Ethical Considerations on Biotechnological Approaches to Mental Health, Well-Being, and Human Flourishing [0.03%]
工程心灵？论生物技术在心理健康、福祉和人类发展方面的伦理考量
Federico Germani,Philipp Kellmeyer,Sebastian Wäscher et al.
Federico Germani et al.
Our bodies can be designed and modified in accordance with our ideals of health and well-being. These increasingly targeted and personalized interventions will be more effective than current therapies. Here we review technologies to alter m...