Discovery and delivery strategies for engineered live biotherapeutic products [0.03%]
工程化活生物治疗产品的发现和递送策略
Mairead K Heavey,Deniz Durmusoglu,Nathan Crook et al.
Mairead K Heavey et al.
Genetically engineered microbes that secrete therapeutics, sense and respond to external environments, and/or target specific sites in the gut fall under an emergent class of therapeutics, called live biotherapeutic products (LBPs). As live...
Stuart J Smyth,Justus Wesseler
Stuart J Smyth
The European Commission (EC) recommends that policy within the EU should consider how to make the regulation of new genomic techniques 'more resilient, future-proof and uniformly applied' than is presently the case. In this article, we expl...
Development of aldolase-based catalysts for the synthesis of organic chemicals [0.03%]
用于有机化合物合成的醛缩酶催化剂的开发
Seon-Hwa Lee,Soo-Jin Yeom,Seong-Eun Kim et al.
Seon-Hwa Lee et al.
Aldol chemicals are synthesized by condensation reactions between the carbon units of ketones and aldehydes using aldolases. The efficient synthesis of diverse organic chemicals requires intrinsic modification of aldolases via engineering a...
Parth Chansoria,Emma L Etter,Juliane Nguyen
Parth Chansoria
The regeneration of dynamic organs remains challenging because they are intrinsically anisotropic and undergo large volumetric deformation during normal or pathological function. This hampers the durability and applicability of regenerative...
The simpler, the better: tissue vascularization using the body's own resources [0.03%]
简化理念最优：利用自体资源实现组织血管化
Matthias W Laschke,Michael D Menger
Matthias W Laschke
Tissue regeneration is crucially dependent on sufficient vascularization. In regenerative medicine, this can be effectively achieved by autologous vascularization strategies using the body's own resources. These strategies include the admin...
Adam M Beitz,Conrad G Oakes,Kate E Galloway
Adam M Beitz
Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits to enhance phenotype-based drug discovery, to map the molecular origins of disease, and to validate therapeutics in complex cellular systems. While d...
Chenba Zhu,Shulin Chen,Yu Ji et al.
Chenba Zhu et al.
Commercial applications of microalgae for biochemicals and fuels are hampered by their high production costs, and the use of conventional carbon supplies is a key reason. Bicarbonate has been proposed as an alternative carbon source due to ...
Nondestructive testing of native and tissue-engineered medical products: adding numbers to pictures [0.03%]
无损检测天然和组织工程医疗器械产品：图像中的数字不容忽视
Nathan J Castro,Greta Babakhanova,Jerry Hu et al.
Nathan J Castro et al.
Traditional destructive tests are used for quality assurance and control within manufacturing workflows. Their applicability to biomanufacturing is limited due to inherent constraints of the biomanufacturing process. To address this, photo-...
Baolei Jia,Xiao Han,Kyung Hyun Kim et al.
Baolei Jia et al.
Advances in technological and bioinformatics approaches have led to the generation of a plethora of human gut metagenomic datasets. Metabolomics has also provided substantial data regarding the small metabolites produced and modified by the...
Multiscale models quantifying yeast physiology: towards a whole-cell model [0.03%]
量化酵母生理的多尺度模型——迈向细胞整体模型
Hongzhong Lu,Eduard J Kerkhoven,Jens Nielsen
Hongzhong Lu
The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important eukaryal model organism for studying cellular physiology related to human health and disease. Yeast was also the first eukaryal organism for which a gen...