Cyanobacterial carbonic anhydrases drive carbon recycling and prodrug biosynthesis in Escherichia coli [0.03%]
蓝藻碳酸酐酶在大肠杆菌中的碳循环和前药生物合成作用研究
Sefli Sri Wahyu Effendi,I-Son Ng
Sefli Sri Wahyu Effendi
Sustainable biomanufacturing in Escherichia coli is advancing through the integration of carbon dioxide (CO2)-fixing modules from algal systems. However, the assimilation efficiency remains limited by ribulose-1,5-bisphosphate carboxylase/o...
Bioengineering CAR-T cells to function in hostile tumor microenvironments [0.03%]
通过生物工程改造CAR-T细胞以在恶劣的肿瘤微环境中发挥功能
Sara Mahajna,Raghad Barhoum,Asala Sabbah et al.
Sara Mahajna et al.
Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in hematological malignancies but remains largely ineffective in solid tumors. Accumulating evidence indicates that this limitation reflects not only suboptimal ...
Jian Li
Jian Li
By reengineering Halomonas bluephagenesis to grow and produce polyhydroxybutyrate under low-salinity, open conditions, Sun et al. transform salinity from a fixed physiological constraint into a bioprocess variable. This study reframes halop...
A bioartificial 3D bronchial epithelial airway model to study lunar hay fever on Earth [0.03%]
一种用于研究月球花粉症的地球生物人工呼吸道模型
Shannon Marchal,Patrick Hellwig,Carlotta Schmidt et al.
Shannon Marchal et al.
A significant challenge for sustained human presence on the Moon revolves around lunar regolith dust. In the past, Apollo astronauts experienced adverse reactions to lunar dust, reporting allergy-like symptoms after tracking the dust into t...
Reversing methanogenic archaea to mitigate anthropogenic methane emissions and generate value-added products [0.03%]
反演产甲烷古菌以减少人为甲烷排放并产生高附加值产品
Yunfeng Yan,Xin Huang,Kaifeng Du et al.
Yunfeng Yan et al.
Nearly 1000 Tg of the greenhouse gas methane are produced annually in diverse anaerobic biospheres. While methanotrophs naturally control atmospheric release by consuming methane, uncontrolled anthropogenic emissions contribute an estimated...
Exponential signal amplification through coupled rolling circle transcription and CRISPR/Cas13a cleavage for ultrasensitive molecular diagnostics [0.03%]
基于转录偶联滚环扩增和CRISPR / Cas13a催化的指数信号放大的超灵敏分子诊断技术
Yongkun Guo,Zaobing Zhu,Can Zhu et al.
Yongkun Guo et al.
Rapid, sensitive nucleic acid detection is crucial for clinical diagnostics, food safety, and environmental monitoring. We present the Sensitive Padlock Rolling-circle INtegrated Transcription with clustered regularly interspaced short pali...
Xingrui Mou,Nathan Dale,Kiran Ramnarine et al.
Xingrui Mou et al.
Complex diseases arise from genetic, environmental, and lifestyle factors, the combination of which is difficult to model. Conventional animal and 2D cell culture models have limitations in scalability, reproducibility, or human relevance. ...
From anti-proliferation to immunomodulation: engineering next-generation cardiovascular biomaterials [0.03%]
从抗增殖到免疫调控：下一代心血管生物材料的构建
Angus J Grant,Khoon S Lim,Richard P Tan et al.
Angus J Grant et al.
Cardiovascular devices such as stents, grafts, and bioprosthetic valves are vital treatments for advanced disease, yet long-term outcomes remain limited by chronic inflammation and poor tissue integration. Conventional drug-eluting devices ...
Next-generation immune models: bioinks, 3D bioprinting, and future directions [0.03%]
下一代免疫模型：生物墨水、3D 生物打印及未来方向
Joel P Joseph,Sriram Bharath Gugulothu,Dipankar Nandi et al.
Joel P Joseph et al.
3D bioprinting has evolved as a promising new approach to build physiologically relevant in vitro tissue microenvironments. Recent evidence demonstrates that microenvironmental cues regulate immune cell activation and function, making biopr...
Multidimensionally engineered Escherichia coli for efficient gadusol biosynthesis with high-throughput quantitative analysis [0.03%]
高效量化分析驱动的多维度工程解偶联大肠杆菌合成gadusol研究
Ping Zhang,Weijiao Zhang,Haibo Xiong et al.
Ping Zhang et al.
Gadusol, as a cyclohexenone compound, has attracted intensive attention because of its sunscreen and antioxidant properties. However, its limited availability, especially from microbial cell factories, hinders its applications. Here, we sys...